Unit 1 – the endocrine system
Endocrine system: system made up of glands that produce and secrete hormones directly into
the bloodstream
Secrete: to release or give off
Gland: group of cells that are specialised to produce and secrete a specific chemical substance
Endocrine gland: a ductless that secretes its hormone directly into the bloodstream
Exocrine gland: gland that secretes its hormone into a duct
Hormone: chemical substance that is produced and secreted in very small amounts into the
bloodstream by the endocrine glands
Target organ: organ that responds to a hormone secreted by an endocrine gland
The endocrine system is made up of glands that produce and secrete hormones directly into the
blood.
• Role: to control and coordinate the life processes in the body in response to changes in the
internal and external environments in such a way that a constant internal environment is
maintained (homeostasis)
• Controls and coordinates the body’s life processes, including growth, development,
metabolism and osmoregulation.
A gland is a group of cells that is specialised to produce and secrete a specific chemical substance
such as a specific hormone.
• Two types of glands: endocrine glands and exocrine glands
• Endocrine glands secrete hormones directly into the blood. Examples of endocrine glands
are the pituitary gland and the thyroid gland.
• Exocrine glands secrete the chemical substance they produce into a duct which carries it to
where it was needed. Examples: digestive glands, salivary glands and sweat glands.
Hormones are secreted in very small amounts into the bloodstream by endocrine glands.
• They act as chemical messengers.
• They transfer information from one set of body cells to another set of body cells in order to
coordinate the functions of different parts of the body.
,Endocrine glands
• Hypothalamus
• The pituitary gland
• The thyroid gland
• The pancreas
• The adrenal gland
• The gonads
Hypothalamus
Hypothalamus: part of the brain that acts an endocrine gland secreting hormone that either
stimulate or suppress the release of hormones by the pituitary gland
Antidiuretic hormone (ADH): hormone produced by the hypothalamus which is stored in the
pituitary gland, allows more water to be re-absorbed into the blood from the kidneys,
reducing the volume of water lost in urine.
The hypothalamus is a part of the brain. It is located below the cerebrum. The hypothalamus is part
of the CNS and endocrine system and links the two systems together.
• CNS: It activates and controls the autonomic nervous system.
• Endocrine system: produces hormones that either stimulate or inhibit the release of
hormones from the pituitary gland.
, • The hypothalamus produces ADH. ADH moves to the pituitary gland via blood vessels that
connect two glands. The pituitary gland stores ADH and secretes the ADH when needed.
• ADH helps regulate the balance of water and salts in the body --> osmoregulation
• ADH increases the permeability of walls of the nephrons in the kidneys which allows more
water to be re-absorbed into the blood.
Pituitary gland
Pituitary gland: endocrine gland at the base of the brain; known as the master gland because it
produces hormones that regulate the secretion of other hormones.
Growth hormone (GH): hormone secreted by the pituitary gland; stimulates protein synthesis,
growth of muscles and bones and the breakdown of fat for energy
Thyroid stimulating hormone (TSH): hormone secreted by the pituitary gland; stimulates the
thyroid gland to secrete thyroxine
Follicle stimulating hormone (FSH): hormone secreted by the pituitary gland; stimulates the
development of follicles in the ovaries and the production of sperm in the testes
Luteinising hormone (LH): hormone secreted by the pituitary gland; in females it causes the
follicle to mature into the corpus luteum and stimulates the secretion of oestrogen and
progesterone; in males it stimulates the secretion of testosterone
Prolactin: hormone secreted by the pituitary gland; stimulates the production of breast milk in
females.
This gland is a pea-sized gland located at the base of the brain. It is linked to the hypothalamus by a
thin stalk. It consists of 2 lobes: anterior in the front and posterior in the back. The anterior lobe is
controlled by hormones from the hypothalamus. The posterior lobe is controlled by nerve impulses
from the hypothalamus.