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Grade 12 IEB DNA and Genetics Notes

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Comprehensive notes on DNA, RNA, replication, protein synthesis, genetics and genetic engineering. Written according to 2026 SAGS, please check for accuracy

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, DNA a Protein
Synthesis
What is DNA ?



Deoxyribonuclei Acid each cell which code for proteins a control protein Synthesis
genes
·



carries in



·


It wa s "discovered" in 1953
by James Watsona Francis Crick


↳ found
they used
X-rays by Rosalind Franklin a Maurice Wilkins

·


Found in the nucleus as part of the chromatin network

↳ It is also found in other
organellesleg
:
Mitochondria a
chloroplasts) as extronuclear DNA




Structure of DNA


·


DNA is shaped like a double helix


·




Building block of DNA-nucleotide

·


Each nucleotide contains :




↳
phosphate group

↳ deoxyribose sugar
↳
nitrogenous base



<
example of a nucleotide




Nucleotides



I . Adenine (purine)
2xHB's

.
2 Thymine (pyramidine)

.
3
Cytosine (pyramidine)
3xHB's

9 . Guanine (purine)




Purine (A + a) =
2 fused
rings

(T C)
Pyramidine
=
one
ring
·
+




So t h at replication
↑
can occur



nucleotides are matched pairs (A + T and C + G) with weak
hydrogen bonds
·



in




*
Only 2% of DNA carries
genetic materials
,
the rest is used in
profiling


Mitochondrial DNA


Double-stranded ring shaped DNA molecule in the mitochondria
,




·



only inherited from mother because all
organelles come from the
egg (only chromosome from sperm)

remains unchanged except for occasional mutations
·




used to trace lineage (matrilineage) and determine relationship using a C A/Mitochondrial Eve
·



.




DNA Replication


the process of making a new DNA molecule which is identical to the parent
·




↳ occurs in the nucleus during interphase




Process


Hellcase causes double hell to and bonds break
1 .
DNA the unwind the
hydrogen to


.
2 Each strand ac ts as a template for free nucleotides in the nucleoplasm to attach to

template ........ 1 f re e
strand
G
nucleotides
.......

Document information

Schooljaar
200
Uploaded on
October 29, 2026
Number of pages
15
Written in
2026/2027
Type
Class notes
Professor(s)
Ieb
Contains
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