Comprehensive Multiple Sclerosis:, STUDY GUIDE WITH COMPLETE SOLUTIONS

Comprehensive Multiple Sclerosis:, STUDY
GUIDE WITH COMPLETE SOLUTIONS
etiology of multiple sclerosis

environmental trigger before puberty in genetically susceptible individuals

-autoimmune component

demographics for multiple sclerosis

-age 20-50

-subset of pediatric MS

-women>men

-more common in northern European descent

pathophysiology of multiple sclerosis

-chronic neuroimmunologic disease of CNS

-UMN

-Inflammatory plaques or lesion during relapse

-or non-inflammatory: neurodegeneration-axonal transection

relapse definition

-new or increased symptoms

-lasts more than 24 hours up to 1-2 months

pseudorelapse defintion

-increase in symptoms

, -less than 24 hrs

-not damaging/not inflammatory

-usually due to exercise, heat, fatigue, UTI

most common clinical features of multiple sclerosis (related to PT)

-fatigue

-heat intolerance

-weakness (primary/secondary)

-decreased aerobic capacity

-impaired balance/ataxia

-sensory loss

-hypertonicity/spasticity

other clinical signs of multiple sclerosis

-bowel and bladder dysfunction

-speech/swallowing impairment

-sleep disturbances

-sexual dysfunction

-impaired cognition

-pain

-depression

-emotional issues

-impaired vision