MGY 250 Unit 9 Quiz Questions with Correct Answers Latest Update 2025/2026
Microsatellite instability analysis involves:
Examining tumour tissue microsatellite stability, which would suggest a mutation in APC
Examining tumour tissue microsatellite stability, which would suggest an error in mismatch
repair
The comparison of normal and tumour tissue to determine if tumour tissue has relatively high
levels of microsatellite instability, which would suggest an error in mismatch repair
The comparison of normal and tumour tissue to determine if tumour tissue has relatively high
levels of microsatellite instability, which would suggest a mutation in APC - Answers The
comparison of normal and tumour tissue to determine if tumour tissue has relatively high levels
of microsatellite instability, which would suggest an error in mismatch repair
When there is a nucleotide mismatch, the following typically occur(s):
It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in DNA base
repair
It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in RNA base
repair
It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in cell cycle
arrest, leading to apoptosis (programmed cell death)
It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in cell cycle
arrest, leading to damage repair - Answers It is recognized by MSH6 and MSH2, which recruit
MLH1 and PMS2 and results in DNA base repair
Chorionic villus sampling (CVS) has an error rate of ~2%. This is because:
The sample is taken from the placenta and sometimes an aneuploidy is present only in the
placenta and not in the fetus, and vice versa
The sample is taken from the amniotic fluid and sometimes an aneuploidy is present only in the
amniotic fluid and not in the fetus, and vice versa
The sample taken from the fetus is minimal and may not have enough information
, The technology used to analyze CVS isn't as advanced - Answers The sample is taken from the
placenta and sometimes an aneuploidy is present only in the placenta and not in the fetus, and
vice versa
The causes of birth defects can be roughly broken down to the following causes:
Complex inheritance 20%, single gene mutations 25%, chromosomal imbalance 50%,
environmental teratogen 25%
Complex inheritance 20%, single gene mutations 25%, chromosomal imbalance 20%,
environmental teratogen 50%
Complex inheritance 5%, single gene mutations 50%, chromosomal imbalance 25%,
environmental teratogen 20%
Complex inheritance 50%, single gene mutations 20%, chromosomal imbalance 25%,
environmental teratogen 5% - Answers Complex inheritance 50%, single gene mutations 20%,
chromosomal imbalance 25%, environmental teratogen 5%
Which of the following statements are true? (select all that apply)
Less than half of all conceptions make it to a stage compatible with life
Of live births, ~20-30% have a major birth defect
More than half of all conceptions make it to a stage compatible with life
Of live births, ~2-3% have a major birth defect - Answers Less than half of all conceptions make
it to a stage compatible with life
Of live births, ~2-3% have a major birth defect
Validation of a next generation sequencing test (select all that apply):
Means that the test is consistent and would provide the same answer when repeated multiple
times
Involves notifying the Ministry of Health
Occurs before optimization of the test
Involves testing for the lowest concentration of DNA at which the test can still be performed
Microsatellite instability analysis involves:
Examining tumour tissue microsatellite stability, which would suggest a mutation in APC
Examining tumour tissue microsatellite stability, which would suggest an error in mismatch
repair
The comparison of normal and tumour tissue to determine if tumour tissue has relatively high
levels of microsatellite instability, which would suggest an error in mismatch repair
The comparison of normal and tumour tissue to determine if tumour tissue has relatively high
levels of microsatellite instability, which would suggest a mutation in APC - Answers The
comparison of normal and tumour tissue to determine if tumour tissue has relatively high levels
of microsatellite instability, which would suggest an error in mismatch repair
When there is a nucleotide mismatch, the following typically occur(s):
It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in DNA base
repair
It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in RNA base
repair
It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in cell cycle
arrest, leading to apoptosis (programmed cell death)
It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in cell cycle
arrest, leading to damage repair - Answers It is recognized by MSH6 and MSH2, which recruit
MLH1 and PMS2 and results in DNA base repair
Chorionic villus sampling (CVS) has an error rate of ~2%. This is because:
The sample is taken from the placenta and sometimes an aneuploidy is present only in the
placenta and not in the fetus, and vice versa
The sample is taken from the amniotic fluid and sometimes an aneuploidy is present only in the
amniotic fluid and not in the fetus, and vice versa
The sample taken from the fetus is minimal and may not have enough information
, The technology used to analyze CVS isn't as advanced - Answers The sample is taken from the
placenta and sometimes an aneuploidy is present only in the placenta and not in the fetus, and
vice versa
The causes of birth defects can be roughly broken down to the following causes:
Complex inheritance 20%, single gene mutations 25%, chromosomal imbalance 50%,
environmental teratogen 25%
Complex inheritance 20%, single gene mutations 25%, chromosomal imbalance 20%,
environmental teratogen 50%
Complex inheritance 5%, single gene mutations 50%, chromosomal imbalance 25%,
environmental teratogen 20%
Complex inheritance 50%, single gene mutations 20%, chromosomal imbalance 25%,
environmental teratogen 5% - Answers Complex inheritance 50%, single gene mutations 20%,
chromosomal imbalance 25%, environmental teratogen 5%
Which of the following statements are true? (select all that apply)
Less than half of all conceptions make it to a stage compatible with life
Of live births, ~20-30% have a major birth defect
More than half of all conceptions make it to a stage compatible with life
Of live births, ~2-3% have a major birth defect - Answers Less than half of all conceptions make
it to a stage compatible with life
Of live births, ~2-3% have a major birth defect
Validation of a next generation sequencing test (select all that apply):
Means that the test is consistent and would provide the same answer when repeated multiple
times
Involves notifying the Ministry of Health
Occurs before optimization of the test
Involves testing for the lowest concentration of DNA at which the test can still be performed
