NURS 5334 Advanced Pharm: Final Exam
Questions and Answers {latest update
2026-2027} 100% Correct – UTA.
what the body does to the drug - correct answer absorption, distribution,
metabolism, excretion
Distribution - correct answer movement of absorbed drug in bodily fluids
throughout the body to target tissue. Properties affecting: lipid/water solubility, PH
affects ionization of drug, protein binding, size of molecule (smaller molecules are
more able to diffuse)
Tissue: fat, bone, blood/brain barrier (only lipid soluble will pass), placental barrier
(many drugs can pass)
Protein binding - correct answer unbound drug is free which is active, crosses
membrane. Low plasma proteins result in more free drug. Competition: when 2 highly
bound drugs are given it increases the level of both drugs
Metabolism - correct answer take place in the liver mostly. Chemical change of a
drug structure to:
Enhance excretion, inactivate the drug, increase therapeutic action, active a prodrug
(inactive until metabolized in the body into the active compound, ex: levodopa),
increase or decrease toxicity
, NURS 5334 Advanced Pharm: Final Exam
Questions and Answers {latest update
2026-2027} 100% Correct – UTA.
CYP450 - correct answer enzymes constitutes the most important of the phase I
metabolizing enzymes (account for about 75% of drug metabolism in the liver)
Phase 2: conjugation reaction occur leading to large increases in hydrophilicity of the
substrates rendering them more readily excretable
Substrate - correct answer an agent that is metabolized by an enzyme into a
metabolite and product and eventually excreted
Inhibitors - correct answer compete with other drugs for a particular enzyme
affecting the metabolism (decreased) of the substrate and decreases the excretion of
the substrate and increasing the circulating drug
inducer - correct answer competes with other drugs for a particular enzyme affecting
metabolism of the substrate (increases) decreasing the efficacy of the drug
excretion - correct answer renal: passive glomerular filtration, active tubular
secretion, tubular reabsorption, gi tract, lung, sweat and salivary, mammary
genomics - correct answer study of the complete set of genetic information present
in a cell, an organism, or species
, NURS 5334 Advanced Pharm: Final Exam
Questions and Answers {latest update
2026-2027} 100% Correct – UTA.
pharmacogenetics - correct answer the study of the influence of hereditary factors
on the response of individual organisms to drugs, and the study of variations of DNA
and RNA characteristics as related to drug response
Pharmacogenetics tests - correct answer Mentioned on drug labels can be classified
as "test required," "test recommended," and "information only." Currently, four drugs
are required to have pharmacogenetics testing performed before they are prescribed:
cetuximab, trastuzumab, maraviroc and dasatinib
wafarin, carbamazepine, valproic acid and abacavir are recommended to tests prior to
initial dosing
Carbamazepine and Asisans - correct answer Initiating carbamazepine therapy in
these patients (allele HLA-B*1502) are at high risk for developing Steven Johnson
syndrome or toxic epidermal necrolysis (TEN)
The ability of the anesthetic to penetrate the axon membrane is determined by 3
properties. What are they? - correct answer Molecular size, Lipid solubility, degree of
ionization at tissue pH
Why is epinephrine given with local anesthetics? - correct answer Decreases local
blood flow (decreased risk of bleeding)
, NURS 5334 Advanced Pharm: Final Exam
Questions and Answers {latest update
2026-2027} 100% Correct – UTA.
Delays systemic absorption of the anesthetic
prolongs anesthesia
reduces the risk of toxicity
What is the most widely used local anesthetic? - correct answer Lidocaine
What is a possible fatal reaction to benzocaine - correct answer Methemoglobinemia
What is included in application guidelines for topical anesthetics - correct answer
avoid wrapping the site and heating the site, avoid application to open skin
Which medication will not cause rebound headaches from overuse? - correct answer
propranolol (preventative)
What is the best option for menstural migraine? - correct answer low dose estrogen
about 3 days prior to menses
What food can trigger migraines? - correct answer Hot dog d/t nitrates
What medication is a Seratonin 1B1D receptor agonist? - correct answer Sumatriptan
Questions and Answers {latest update
2026-2027} 100% Correct – UTA.
what the body does to the drug - correct answer absorption, distribution,
metabolism, excretion
Distribution - correct answer movement of absorbed drug in bodily fluids
throughout the body to target tissue. Properties affecting: lipid/water solubility, PH
affects ionization of drug, protein binding, size of molecule (smaller molecules are
more able to diffuse)
Tissue: fat, bone, blood/brain barrier (only lipid soluble will pass), placental barrier
(many drugs can pass)
Protein binding - correct answer unbound drug is free which is active, crosses
membrane. Low plasma proteins result in more free drug. Competition: when 2 highly
bound drugs are given it increases the level of both drugs
Metabolism - correct answer take place in the liver mostly. Chemical change of a
drug structure to:
Enhance excretion, inactivate the drug, increase therapeutic action, active a prodrug
(inactive until metabolized in the body into the active compound, ex: levodopa),
increase or decrease toxicity
, NURS 5334 Advanced Pharm: Final Exam
Questions and Answers {latest update
2026-2027} 100% Correct – UTA.
CYP450 - correct answer enzymes constitutes the most important of the phase I
metabolizing enzymes (account for about 75% of drug metabolism in the liver)
Phase 2: conjugation reaction occur leading to large increases in hydrophilicity of the
substrates rendering them more readily excretable
Substrate - correct answer an agent that is metabolized by an enzyme into a
metabolite and product and eventually excreted
Inhibitors - correct answer compete with other drugs for a particular enzyme
affecting the metabolism (decreased) of the substrate and decreases the excretion of
the substrate and increasing the circulating drug
inducer - correct answer competes with other drugs for a particular enzyme affecting
metabolism of the substrate (increases) decreasing the efficacy of the drug
excretion - correct answer renal: passive glomerular filtration, active tubular
secretion, tubular reabsorption, gi tract, lung, sweat and salivary, mammary
genomics - correct answer study of the complete set of genetic information present
in a cell, an organism, or species
, NURS 5334 Advanced Pharm: Final Exam
Questions and Answers {latest update
2026-2027} 100% Correct – UTA.
pharmacogenetics - correct answer the study of the influence of hereditary factors
on the response of individual organisms to drugs, and the study of variations of DNA
and RNA characteristics as related to drug response
Pharmacogenetics tests - correct answer Mentioned on drug labels can be classified
as "test required," "test recommended," and "information only." Currently, four drugs
are required to have pharmacogenetics testing performed before they are prescribed:
cetuximab, trastuzumab, maraviroc and dasatinib
wafarin, carbamazepine, valproic acid and abacavir are recommended to tests prior to
initial dosing
Carbamazepine and Asisans - correct answer Initiating carbamazepine therapy in
these patients (allele HLA-B*1502) are at high risk for developing Steven Johnson
syndrome or toxic epidermal necrolysis (TEN)
The ability of the anesthetic to penetrate the axon membrane is determined by 3
properties. What are they? - correct answer Molecular size, Lipid solubility, degree of
ionization at tissue pH
Why is epinephrine given with local anesthetics? - correct answer Decreases local
blood flow (decreased risk of bleeding)
, NURS 5334 Advanced Pharm: Final Exam
Questions and Answers {latest update
2026-2027} 100% Correct – UTA.
Delays systemic absorption of the anesthetic
prolongs anesthesia
reduces the risk of toxicity
What is the most widely used local anesthetic? - correct answer Lidocaine
What is a possible fatal reaction to benzocaine - correct answer Methemoglobinemia
What is included in application guidelines for topical anesthetics - correct answer
avoid wrapping the site and heating the site, avoid application to open skin
Which medication will not cause rebound headaches from overuse? - correct answer
propranolol (preventative)
What is the best option for menstural migraine? - correct answer low dose estrogen
about 3 days prior to menses
What food can trigger migraines? - correct answer Hot dog d/t nitrates
What medication is a Seratonin 1B1D receptor agonist? - correct answer Sumatriptan
