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Lecture notes

Red Blood Cells & Hemoglobin

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This document provides a comprehensive overview of red blood cells (RBCs) and hemoglobin, covering their structure, composition, and function, as well as erythropoiesis (RBC production), regulation, lifespan, and breakdown. It explains hemoglobin forms, including oxyhemoglobin, deoxyhemoglobin, carbaminohemoglobin, and NO transport, and details the effects of poisons like carbon monoxide. The document also addresses genetic disorders such as sickle-cell disease, the role of erythropoietin in RBC production, and clinical aspects such as reticulocyte counts and jaundice. Key processes like heme breakdown, iron recycling, and bilirubin metabolism are included, making it a complete study resource for blood physiology.

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Blood as a Connective Tissue
 Blood is a type of connective tissue.
 It consists of:
o A liquid matrix
o Cells and cell fragments
 The liquid matrix in blood is called plasma.
 The cells and cell fragments are collectively called the formed elements.




2. Plasma
 Plasma is the liquid matrix of blood.
 It makes up 55% of the total blood volume.




3. Formed Elements
 The formed elements are the cells and cell fragments in blood.
 They make up 45% of the total blood volume.




4. Total Blood Volume
 In the average adult female, total blood volume is 4–5 L.
 In the average adult male, total blood volume is 5–6 L.




5. Blood as a Percentage of Body Weight
 Blood makes up about 8% of the total weight of the body.




Plasma Overview
 Plasma (PLAZ-mah) is the liquid matrix of blood.
 It is described as a pale yellow fluid.




Plasma Composition

,  Plasma consists of:
o About 91% water
o About 9% other substances
 The other substances include:
o Proteins
o Ions
o Nutrients
o Gases
o Waste products
o Regulatory substances
 Reference: (L" table 19.1).




Plasma as a Colloid
 Plasma is a colloid (KOL-oyd).
 A colloid is defined as a liquid containing suspended substances that do not settle
out of solution.
 In plasma, most of the suspended substances are plasma proteins.




Plasma Proteins
 Plasma proteins make up about 7% of the volume of plasma.
 Reference: (L$ figure 19.1).
 Plasma proteins can be classified into three groups, based on molecular size and
charge:
1. Albumins
2. Globulins
3. Fibrinogen




Production of Plasma Proteins
 Almost all of the plasma proteins are produced by the liver or blood cells.
 A notable exception is protein hormones, which are not included in this group.

Production of Formed Elements
Definition of the Process

 The process of blood cell production is called:
o Hematopoiesis (hee-MA-toh-poy-EE-sis), or
o Hemopoiesis (HEE-moh-poy-EE-sis).

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Uploaded on
November 14, 2025
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2023/2024
Type
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Liu joan
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