PCB 3233 Immunology Exam 4
Study online at https://quizlet.com/_6e9fnh
1. Positive Selection makes sure that your T-Cell recognizes one of your MHC.
If it does not, then apoptosis
2. Negative Selection Makes sure it does not recognize your peptide:MHC too strongly
3. Does gamma: delta No
T-cells have to go
through positive selec-
tion?
4. What does turning off Preserve the current rearrangement
RAG 1&2 do to your
gene rearrangement?
5. Primary Lymphoid Tis- bone marrow and thymus
sue
6. What does TH1 cells do? Activate macrophages
7. Thymal Stromal Cells Keeps BCR genes closed and opens TCR genes
8. IgM activates? complement
9. Notch-1 The signal for survival. It drives the cell on the T-cell path — signals to
open up T-cell rearrangement.
Signaling rearrangement keeps T-cel on T-cell pathway
10. Where does Maturation Cortex of the thymus
and Positive Selection
occur?
11.
, PCB 3233 Immunology Exam 4
Study online at https://quizlet.com/_6e9fnh
Can negative selection Yes, negative selection can take place in the cortex at the same time as
also take place in the positive selection
Cortex?
12. Where does negative medulla of thymus
selection take place?
13. Where are mature thy- Medulla
mocytes located?
14. Where are immature Cortex
thymocytes located?
15. What special cells are in Dendritic cells, macrophages, and medullary epithelial cells
the Medulla
16. What special cells are in Cortical epithelial cells and macrophages
the cortex?
17. Where can you find in the medullary epithelial cells
AIRE?
18. AIRE Autoimmune regulator
made by medullary epithelial cells
Creates a couple hundred peripheral peptides that can be used to test
T-cells for negative selection
19. DiGeorge's syndrome deletion in chromosome 22 in which thymus fails to develop and T-cells
are absent
20. Hassall's corpuscles macrophages in both cortex and medulla remove the many thymocytes
that fail to mature properly
, PCB 3233 Immunology Exam 4
Study online at https://quizlet.com/_6e9fnh
21. Involution of the Thy- Progressively shrinks, fat gradually claiming areas once packed with
mus thymocytes
-reduces production of new T-cells
22. Double negative No CD4 and CD8
23. Double Positive CD4 and CD8 are present
24. Single Positive has either CD4 or CD8
25. CD2 and CD5 perform adhesion and signaling. They are present during double neg-
ative stage
26. Thymocytes rearrange Beta, gamma, and delta
which 3 genes at the
same time?
27. pTalpha surrogate alpha chain. signals cell to halt gamma, delta, Beta chains,
gene rearrangement and begin proliferation.
28. What do macrophages continually remove dead cells
do in the thymus?
29. How many rearrange- up to 4 attempts
ments can successfully
make a Beta chain?
30. d:k light chain can have 4 minimum attempts
a minimum of how
many rearrangements?
31. alpha chain allows 2 attempts
many successive re-
Study online at https://quizlet.com/_6e9fnh
1. Positive Selection makes sure that your T-Cell recognizes one of your MHC.
If it does not, then apoptosis
2. Negative Selection Makes sure it does not recognize your peptide:MHC too strongly
3. Does gamma: delta No
T-cells have to go
through positive selec-
tion?
4. What does turning off Preserve the current rearrangement
RAG 1&2 do to your
gene rearrangement?
5. Primary Lymphoid Tis- bone marrow and thymus
sue
6. What does TH1 cells do? Activate macrophages
7. Thymal Stromal Cells Keeps BCR genes closed and opens TCR genes
8. IgM activates? complement
9. Notch-1 The signal for survival. It drives the cell on the T-cell path — signals to
open up T-cell rearrangement.
Signaling rearrangement keeps T-cel on T-cell pathway
10. Where does Maturation Cortex of the thymus
and Positive Selection
occur?
11.
, PCB 3233 Immunology Exam 4
Study online at https://quizlet.com/_6e9fnh
Can negative selection Yes, negative selection can take place in the cortex at the same time as
also take place in the positive selection
Cortex?
12. Where does negative medulla of thymus
selection take place?
13. Where are mature thy- Medulla
mocytes located?
14. Where are immature Cortex
thymocytes located?
15. What special cells are in Dendritic cells, macrophages, and medullary epithelial cells
the Medulla
16. What special cells are in Cortical epithelial cells and macrophages
the cortex?
17. Where can you find in the medullary epithelial cells
AIRE?
18. AIRE Autoimmune regulator
made by medullary epithelial cells
Creates a couple hundred peripheral peptides that can be used to test
T-cells for negative selection
19. DiGeorge's syndrome deletion in chromosome 22 in which thymus fails to develop and T-cells
are absent
20. Hassall's corpuscles macrophages in both cortex and medulla remove the many thymocytes
that fail to mature properly
, PCB 3233 Immunology Exam 4
Study online at https://quizlet.com/_6e9fnh
21. Involution of the Thy- Progressively shrinks, fat gradually claiming areas once packed with
mus thymocytes
-reduces production of new T-cells
22. Double negative No CD4 and CD8
23. Double Positive CD4 and CD8 are present
24. Single Positive has either CD4 or CD8
25. CD2 and CD5 perform adhesion and signaling. They are present during double neg-
ative stage
26. Thymocytes rearrange Beta, gamma, and delta
which 3 genes at the
same time?
27. pTalpha surrogate alpha chain. signals cell to halt gamma, delta, Beta chains,
gene rearrangement and begin proliferation.
28. What do macrophages continually remove dead cells
do in the thymus?
29. How many rearrange- up to 4 attempts
ments can successfully
make a Beta chain?
30. d:k light chain can have 4 minimum attempts
a minimum of how
many rearrangements?
31. alpha chain allows 2 attempts
many successive re-
