Berne and Levy Physiology 7th Edition KoeppenTest Bank
Koeppen: Berne and Levy Physiology, 7th Edition
Chapter 01: Principles of Cell
FunctionTest Bank
Multiple Choice
1. The subcellular structure that degrades proteins is called the:
A. Tight junction
B. Mitochondria
C. Lysosome
D. Plasma membrane
E. Ribosome
ANS: C
2. An experiment is done to measure the uptake of an amino acid into a cell. The following
data are obtained:
N
If Na+ is removed from the extracellular bathing solution, or if a drug is added that prevents the
cell from making adenosine triphosphate (ATP), the uptake of amino acid into the cell is
markedly reduced. According to this information, which of the followingmechanisms is
probably responsible for the transport of the amino acid into the cell?
A. Passive diffusion through the lipid bilayer
B. Uniporter
C. Transport ATPase
D. Na+ symporter
E. Na+ antiporter
ANS: D
3. A membrane permeable by only Na+ separates two compartments containing
Na2SO4,shown as follows:
,Electrodes are placed in both compartments, and a voltage is applied (that of compartment A is
held at 0 mV). What voltage applied to compartment B would result in no net movement of Na+
across the membrane separating the compartments?
A. –60 mV
B. –30 mV
C. 0 mV
D. +30 mV
E. +60 mV
ANS: E
4. The resting membrane potentN ial oRfa I
ce ll is –85.C
mV. The intracellular and extracellular
concentrations of several ions are S N G inBthe
U indicated following table, as is the calculated
Nernst equilibrium potential (Ei) for each of these ions:
Ion Concentration Concentration Ei
Inside Cell Outside Cell
Na+ 12 mEq/L 145 mEq/L 66 mV
K+ 150 mEq/L 4 mEq/L –96 mV
Cl– 30 mEq/L 105 mEq/L –33 mV
Ca++ 0.0001 mmol/dL 1 mmol/dL 122 mV
The membrane has channels for Na+, K+, Cl–, and Ca++. The conductance of the
membrane is the greatest for which ion?
A. Na+
B. K+
C. Cl–
D. Ca++
ANS: B
5. A cell contains the following membrane transporters:
Na+ channelK+ channel
Na+,K+-ATPase
The resting membrane voltage of the cell is –80 mV, and the intracellular and
,extracellular ion concentrations are as follows:
Ion Intracellular Extracellular
Concentration Concentration
Na+ 10 mEq/L 145 mEq/L
K+ 120 mEq/L 4 mEq/L
The cell is treated with a drug to inhibit the Na+,K+-ATPase. What would be the effect ofthis drug
on the following parameters?
Intracellular [Na+] Intracellular [K+] Cell Volume Membrane Voltage
A. Decrease Decrease Decrease Depolarize
B. Increase Decrease Increase Depolarize
C. Increase Increase Increase No change
D. Decrease Increase Decrease Hyperpolarize
E. Increase Increase Decrease Hyperpolarize
ANS: B
6. Which of the labeled proteins (shaded) is attached to the membrane by a
glycosylphosphatidylinositol (GPI) anchor?
ANS: E
7. A cell has channels for Na+, K+, and Cl– in its plasma membrane. The resting membrane
potential is –60 mV (cell interior negative). The intracellular and extracellular
concentrations for these ions, as well as the calculated Nernst potentials, are listed as
follows:
, Ion Intracellular Extracellular Ei
Concentration Concentration
Na+ 14 nmEq/L 140 nmEq/L 60 nmV
K+ 150 nmEq/L 5 nmEq/L –89 nmV
Cl– 10 nmEq/L 100 nmEq/L –60 nmV
A ndrug nis napplied nto nthe ncell nthat nincreases nthe npermeability nof nthe ncell nby nCl– n(i.e., nit
– –
nopens nCl nchannels). nWhat neffect nwill nthis ndrug nhave non nthe nnet nmovement nof nCl
nacrossthe nplasma nmembrane?
A. Net nCl– n movement nout nof nthe ncell nwill nbe nincreased.
B. Net nCl– nmovement ninto nthe ncell nwill nbe nincreased.
C. There nwill nbe nno nchange nin nthe nnet nmovement nof nCl–.
ANS: n C
8. Reducing nthe nextracellular n[K+] nwould nbe nexpected nto nhave nwhich nof nthe
nfollowing neffects non nthe nresting nmembrane npotential nand non nthe
nexcitability nof nventricular nmyocytes?
Membrane nPotential Excitability
A. Unchanged Unchanged
B. Hyperpolarized GDT
ecBre.aC
seO
d
C. Hyperpolarized Increased
D. Depolarized Decreased
E. Depolarized Increased
ANS: n B
9. A ncell nis nbathed nin nan nisotonic nNaCl nsolution nthat ncontains n5 nmmol/L nof
nglucose. nThe nintracellular nconcentration nof nglucose nis n10 nmmol/L. nWhat nis nthe
nmost nlikely nmechanism nfor nthe ntransport nof nglucose nacross nthe nplasma
nmembrane ninto nthis ncell?
A. Glucose nuniporter
B. Na+-glucose nsymporter
C. Na+-glucose nantiporter
D. Diffusion nof nglucose nthrough nthe nlipid nbilayer nof nthe
nmembrane nANS: n B
10. A nblood nsample nis ntaken nfrom nan nindividual nwhose nblood nosmolality nis n295
nmOsm nper nkilogram nof nwater. nRed nblood ncells nfrom nthis nsample nare nthen
nplaced nin nthe nfollowing nsolutions:
Koeppen: Berne and Levy Physiology, 7th Edition
Chapter 01: Principles of Cell
FunctionTest Bank
Multiple Choice
1. The subcellular structure that degrades proteins is called the:
A. Tight junction
B. Mitochondria
C. Lysosome
D. Plasma membrane
E. Ribosome
ANS: C
2. An experiment is done to measure the uptake of an amino acid into a cell. The following
data are obtained:
N
If Na+ is removed from the extracellular bathing solution, or if a drug is added that prevents the
cell from making adenosine triphosphate (ATP), the uptake of amino acid into the cell is
markedly reduced. According to this information, which of the followingmechanisms is
probably responsible for the transport of the amino acid into the cell?
A. Passive diffusion through the lipid bilayer
B. Uniporter
C. Transport ATPase
D. Na+ symporter
E. Na+ antiporter
ANS: D
3. A membrane permeable by only Na+ separates two compartments containing
Na2SO4,shown as follows:
,Electrodes are placed in both compartments, and a voltage is applied (that of compartment A is
held at 0 mV). What voltage applied to compartment B would result in no net movement of Na+
across the membrane separating the compartments?
A. –60 mV
B. –30 mV
C. 0 mV
D. +30 mV
E. +60 mV
ANS: E
4. The resting membrane potentN ial oRfa I
ce ll is –85.C
mV. The intracellular and extracellular
concentrations of several ions are S N G inBthe
U indicated following table, as is the calculated
Nernst equilibrium potential (Ei) for each of these ions:
Ion Concentration Concentration Ei
Inside Cell Outside Cell
Na+ 12 mEq/L 145 mEq/L 66 mV
K+ 150 mEq/L 4 mEq/L –96 mV
Cl– 30 mEq/L 105 mEq/L –33 mV
Ca++ 0.0001 mmol/dL 1 mmol/dL 122 mV
The membrane has channels for Na+, K+, Cl–, and Ca++. The conductance of the
membrane is the greatest for which ion?
A. Na+
B. K+
C. Cl–
D. Ca++
ANS: B
5. A cell contains the following membrane transporters:
Na+ channelK+ channel
Na+,K+-ATPase
The resting membrane voltage of the cell is –80 mV, and the intracellular and
,extracellular ion concentrations are as follows:
Ion Intracellular Extracellular
Concentration Concentration
Na+ 10 mEq/L 145 mEq/L
K+ 120 mEq/L 4 mEq/L
The cell is treated with a drug to inhibit the Na+,K+-ATPase. What would be the effect ofthis drug
on the following parameters?
Intracellular [Na+] Intracellular [K+] Cell Volume Membrane Voltage
A. Decrease Decrease Decrease Depolarize
B. Increase Decrease Increase Depolarize
C. Increase Increase Increase No change
D. Decrease Increase Decrease Hyperpolarize
E. Increase Increase Decrease Hyperpolarize
ANS: B
6. Which of the labeled proteins (shaded) is attached to the membrane by a
glycosylphosphatidylinositol (GPI) anchor?
ANS: E
7. A cell has channels for Na+, K+, and Cl– in its plasma membrane. The resting membrane
potential is –60 mV (cell interior negative). The intracellular and extracellular
concentrations for these ions, as well as the calculated Nernst potentials, are listed as
follows:
, Ion Intracellular Extracellular Ei
Concentration Concentration
Na+ 14 nmEq/L 140 nmEq/L 60 nmV
K+ 150 nmEq/L 5 nmEq/L –89 nmV
Cl– 10 nmEq/L 100 nmEq/L –60 nmV
A ndrug nis napplied nto nthe ncell nthat nincreases nthe npermeability nof nthe ncell nby nCl– n(i.e., nit
– –
nopens nCl nchannels). nWhat neffect nwill nthis ndrug nhave non nthe nnet nmovement nof nCl
nacrossthe nplasma nmembrane?
A. Net nCl– n movement nout nof nthe ncell nwill nbe nincreased.
B. Net nCl– nmovement ninto nthe ncell nwill nbe nincreased.
C. There nwill nbe nno nchange nin nthe nnet nmovement nof nCl–.
ANS: n C
8. Reducing nthe nextracellular n[K+] nwould nbe nexpected nto nhave nwhich nof nthe
nfollowing neffects non nthe nresting nmembrane npotential nand non nthe
nexcitability nof nventricular nmyocytes?
Membrane nPotential Excitability
A. Unchanged Unchanged
B. Hyperpolarized GDT
ecBre.aC
seO
d
C. Hyperpolarized Increased
D. Depolarized Decreased
E. Depolarized Increased
ANS: n B
9. A ncell nis nbathed nin nan nisotonic nNaCl nsolution nthat ncontains n5 nmmol/L nof
nglucose. nThe nintracellular nconcentration nof nglucose nis n10 nmmol/L. nWhat nis nthe
nmost nlikely nmechanism nfor nthe ntransport nof nglucose nacross nthe nplasma
nmembrane ninto nthis ncell?
A. Glucose nuniporter
B. Na+-glucose nsymporter
C. Na+-glucose nantiporter
D. Diffusion nof nglucose nthrough nthe nlipid nbilayer nof nthe
nmembrane nANS: n B
10. A nblood nsample nis ntaken nfrom nan nindividual nwhose nblood nosmolality nis n295
nmOsm nper nkilogram nof nwater. nRed nblood ncells nfrom nthis nsample nare nthen
nplaced nin nthe nfollowing nsolutions:
