Hyperthyroidism (Smarty PANCE) Test Questions and Answers
Rated A
What is hyperthyroidism? - Hyperthyroidism noncompliant or refractory to medicines,
is a metabolic imbalance that results from the pregnant, a child, or if patient refuses radioiodide
overproduction of the thyroid hormones T4 and therapy
T3
What is thyroid storm?- Thyroid storm is an
What is the most common cause of acute form of hyperthyroidism that results from
hyperthyroidism?- Graves’ disease, which untreated or inadequately treated severe
is an autoimmune disorder, is considered the hyperthyroidism. It may be precipitated by
most common form; however, toxic nodular infection, trauma, surgery, embolism, diabetic
goiter, thyroiditis, excess iodine intake, pituitary ketoacidosis, or preeclampsia. Thyroid storm
and thyroid tumors have symptoms of elevated causes abrupt florid symptoms of
thyroid hormone. hyperthyroidism with one or more of the
following: fever, marked weakness and muscle
Classic findings of Graves' disease?- wasting, extreme restlessness with wide
Classic findings include pretibial emotional swings, confusion, psychosis, coma,
myxedema and exophthalmos. Patients display nausea, vomiting, diarrhea, and hepatomegaly
hyperthyroid symptoms (goiter, heat intolerance, with mild jaundice. The patient may present with
weight loss, insomnia, hyperactivity, and cardiovascular collapse and shock. Thyroid storm
palpitations) due to IgG antibodies which activate is a life-threatening emergency requiring prompt
TSH receptors, leading to release of thyroid treatment.
hormones.
What is the major complication of radioiodide or
What is the female : male ratio of graves surgery for Graves' disease?-
disease?- 6:1 Hypothyroidism
What specific physical finding is associated with What does PTU stand for?-
Graves' disease?- Exophthalmos PropylThioUracil
Typical lab values in patients with Graves' How does PTU work?- 1. Inhibits
disease?- Typical lab values in patients incorporation of iodine into T4/T3 (by blocking
with Graves' disease include decreased TSH, peroxidase oxidation of iodide to iodine)
increased thyroid hormones (T3, T4), and 2. Inhibits peripheral conversion of T4 to T3
increased radioactive iodine uptake when tested.
How does methimazole work?- Inhibits
Name treatment option modalities for Graves' incorporation of iodine into T4/T3 only (by
disease- 1. Medical blockade: iodide, blocking peroxidase oxidation of iodide to iodine)
propranolol, propylthiouracil (PTU), methimazole,
Lugol's solution (potassium iodide)
2. Radioiodide ablation: most popular therapy
3. Surgical resection (bilateral subtotal
thyroidectomy)
What are the possible indications for surgical
resection?- Suspicious nodule; if patient is
1/1
Rated A
What is hyperthyroidism? - Hyperthyroidism noncompliant or refractory to medicines,
is a metabolic imbalance that results from the pregnant, a child, or if patient refuses radioiodide
overproduction of the thyroid hormones T4 and therapy
T3
What is thyroid storm?- Thyroid storm is an
What is the most common cause of acute form of hyperthyroidism that results from
hyperthyroidism?- Graves’ disease, which untreated or inadequately treated severe
is an autoimmune disorder, is considered the hyperthyroidism. It may be precipitated by
most common form; however, toxic nodular infection, trauma, surgery, embolism, diabetic
goiter, thyroiditis, excess iodine intake, pituitary ketoacidosis, or preeclampsia. Thyroid storm
and thyroid tumors have symptoms of elevated causes abrupt florid symptoms of
thyroid hormone. hyperthyroidism with one or more of the
following: fever, marked weakness and muscle
Classic findings of Graves' disease?- wasting, extreme restlessness with wide
Classic findings include pretibial emotional swings, confusion, psychosis, coma,
myxedema and exophthalmos. Patients display nausea, vomiting, diarrhea, and hepatomegaly
hyperthyroid symptoms (goiter, heat intolerance, with mild jaundice. The patient may present with
weight loss, insomnia, hyperactivity, and cardiovascular collapse and shock. Thyroid storm
palpitations) due to IgG antibodies which activate is a life-threatening emergency requiring prompt
TSH receptors, leading to release of thyroid treatment.
hormones.
What is the major complication of radioiodide or
What is the female : male ratio of graves surgery for Graves' disease?-
disease?- 6:1 Hypothyroidism
What specific physical finding is associated with What does PTU stand for?-
Graves' disease?- Exophthalmos PropylThioUracil
Typical lab values in patients with Graves' How does PTU work?- 1. Inhibits
disease?- Typical lab values in patients incorporation of iodine into T4/T3 (by blocking
with Graves' disease include decreased TSH, peroxidase oxidation of iodide to iodine)
increased thyroid hormones (T3, T4), and 2. Inhibits peripheral conversion of T4 to T3
increased radioactive iodine uptake when tested.
How does methimazole work?- Inhibits
Name treatment option modalities for Graves' incorporation of iodine into T4/T3 only (by
disease- 1. Medical blockade: iodide, blocking peroxidase oxidation of iodide to iodine)
propranolol, propylthiouracil (PTU), methimazole,
Lugol's solution (potassium iodide)
2. Radioiodide ablation: most popular therapy
3. Surgical resection (bilateral subtotal
thyroidectomy)
What are the possible indications for surgical
resection?- Suspicious nodule; if patient is
1/1
