Intro lecture

1. Introduction of
Outlineprimary recovery
2. Fundamentals of Centrifugation
3. Different Centrifuges
4. Centrifugation Process Design
5. Ultra Scale-down of Centrifugation
6. Case Study 1: Rapid Evaluation of Solid
Liquid Operations

1

,Ultra scale-down of Centrifugation
1. What is ultra scale-down and why do it?
2. Ultra scale-down device and critical regime
analysis
3. Critical regime analysis for industrial scale
centrifuge
4. Ultra scale-down study to predict the performance
of industrial scale centrifuges

,1. What is ultra scale-down (USD)?
1.The ability to research at a small scale and
provide new insights into how a
bioprocessing material is impacted by the
process engineering environment
2. The ability to inform on how to scale up
and provide material representative of full
scale

, Why do it?
1.Test cells and product candidates for
“manufacturability”, early and at low cost
2. Address novel bioprocessing solutions,
early and at low cost
3. Resolve large-scale manufacturing
challenges, early and at low cost
4. Help meet regulatory challenges
5. Move with speed to manufacture when
clinical indications are positive