Pharmacokinetics Nclex Questions
and Answers | Latest Version |
2025/2026 | Correct & Verified
Which route of administration generally has the fastest onset of action?
A. Oral
B. Subcutaneous
✔✔C. Intravenous
D. Topical
What does bioavailability refer to?
A. The rate of drug metabolism
✔✔B. The proportion of a drug that reaches systemic circulation unchanged
C. The half-life of a drug
D. The volume of distribution
Which organ is primarily responsible for drug metabolism?
A. Kidney
B. Lungs
1
,✔✔C. Liver
D. Spleen
What is the primary route of drug excretion?
A. Liver
B. Sweat
✔✔C. Kidneys
D. Lungs
Which factor can increase drug absorption in the gastrointestinal tract?
A. Decreased blood flow
✔✔B. Increased surface area
C. High gastric pH
D. Food interaction
Which term describes the time it takes for the plasma concentration of a drug to decrease by
half?
A. Clearance
2
, B. Onset of action
✔✔C. Half-life
D. Bioavailability
What is the first-pass effect?
✔✔Metabolism of a drug by the liver before it reaches systemic circulation.
A. Excretion through the kidneys
B. Drug absorption in the stomach
C. Drug binding to plasma proteins
Which factor decreases drug distribution?
A. High tissue perfusion
✔✔B. Low plasma protein levels
C. Lipid solubility
D. Large volume of distribution
Which protein is most important for binding drugs in the blood?
A. Hemoglobin
3
and Answers | Latest Version |
2025/2026 | Correct & Verified
Which route of administration generally has the fastest onset of action?
A. Oral
B. Subcutaneous
✔✔C. Intravenous
D. Topical
What does bioavailability refer to?
A. The rate of drug metabolism
✔✔B. The proportion of a drug that reaches systemic circulation unchanged
C. The half-life of a drug
D. The volume of distribution
Which organ is primarily responsible for drug metabolism?
A. Kidney
B. Lungs
1
,✔✔C. Liver
D. Spleen
What is the primary route of drug excretion?
A. Liver
B. Sweat
✔✔C. Kidneys
D. Lungs
Which factor can increase drug absorption in the gastrointestinal tract?
A. Decreased blood flow
✔✔B. Increased surface area
C. High gastric pH
D. Food interaction
Which term describes the time it takes for the plasma concentration of a drug to decrease by
half?
A. Clearance
2
, B. Onset of action
✔✔C. Half-life
D. Bioavailability
What is the first-pass effect?
✔✔Metabolism of a drug by the liver before it reaches systemic circulation.
A. Excretion through the kidneys
B. Drug absorption in the stomach
C. Drug binding to plasma proteins
Which factor decreases drug distribution?
A. High tissue perfusion
✔✔B. Low plasma protein levels
C. Lipid solubility
D. Large volume of distribution
Which protein is most important for binding drugs in the blood?
A. Hemoglobin
3
