PTCB Drugs with Side Effects,
Interactions, And Contraindications By
Classification Questions and Answers
| Latest Version | 2025/2026 | Correct &
Verified
Which class of antibiotics is commonly associated with tendon rupture as a serious side effect?
✔✔ Fluoroquinolones
Which medication is contraindicated in patients with a history of angioedema caused by ACE
inhibitors?
✔✔ Lisinopril
What is a common side effect of beta-blockers like metoprolol?
✔✔ Bradycardia and fatigue
Which drug class can cause ototoxicity when combined with loop diuretics?
✔✔ Aminoglycoside antibiotics
1
,What is a major drug interaction concern with warfarin?
✔✔ Increased risk of bleeding when combined with NSAIDs
Which antihypertensive medication can cause a persistent dry cough?
✔✔ ACE inhibitors
What serious adverse effect is associated with the use of statins?
✔✔ Rhabdomyolysis
Which drug is contraindicated in patients with severe asthma due to risk of bronchospasm?
✔✔ Non-selective beta-blockers
Which class of drugs can cause hyperkalemia as a side effect?
✔✔ ACE inhibitors and potassium-sparing diuretics
Which medication may cause QT interval prolongation and increase risk of torsades de pointes?
✔✔ Macrolide antibiotics
2
,Which drug interaction is a concern with digoxin therapy?
✔✔ Increased digoxin levels when taken with verapamil or amiodarone
What is a common side effect of loop diuretics like furosemide?
✔✔ Hypokalemia and dehydration
Which anticoagulant is contraindicated in pregnancy due to teratogenicity?
✔✔ Warfarin
Which class of medications can cause weight gain and fluid retention?
✔✔ Corticosteroids
Which medication is contraindicated in patients with severe liver impairment?
✔✔ Acetaminophen in high doses
What is a common side effect of SSRIs such as sertraline?
✔✔ Nausea, insomnia, and sexual dysfunction
3
, Which drug can interact with grapefruit juice, leading to increased plasma levels?
✔✔ Statins and certain calcium channel blockers
Which antihypertensive class can cause reflex tachycardia if stopped abruptly?
✔✔ Beta-blockers
Which NSAID can increase the risk of gastrointestinal bleeding when taken with anticoagulants?
✔✔ Ibuprofen
Which drug is contraindicated in patients with history of sulfa allergy?
✔✔ Sulfonamide antibiotics
Which medication may cause peripheral edema as a side effect?
✔✔ Calcium channel blockers
Which drug interaction can occur between lithium and thiazide diuretics?
✔✔ Increased risk of lithium toxicity
4
Interactions, And Contraindications By
Classification Questions and Answers
| Latest Version | 2025/2026 | Correct &
Verified
Which class of antibiotics is commonly associated with tendon rupture as a serious side effect?
✔✔ Fluoroquinolones
Which medication is contraindicated in patients with a history of angioedema caused by ACE
inhibitors?
✔✔ Lisinopril
What is a common side effect of beta-blockers like metoprolol?
✔✔ Bradycardia and fatigue
Which drug class can cause ototoxicity when combined with loop diuretics?
✔✔ Aminoglycoside antibiotics
1
,What is a major drug interaction concern with warfarin?
✔✔ Increased risk of bleeding when combined with NSAIDs
Which antihypertensive medication can cause a persistent dry cough?
✔✔ ACE inhibitors
What serious adverse effect is associated with the use of statins?
✔✔ Rhabdomyolysis
Which drug is contraindicated in patients with severe asthma due to risk of bronchospasm?
✔✔ Non-selective beta-blockers
Which class of drugs can cause hyperkalemia as a side effect?
✔✔ ACE inhibitors and potassium-sparing diuretics
Which medication may cause QT interval prolongation and increase risk of torsades de pointes?
✔✔ Macrolide antibiotics
2
,Which drug interaction is a concern with digoxin therapy?
✔✔ Increased digoxin levels when taken with verapamil or amiodarone
What is a common side effect of loop diuretics like furosemide?
✔✔ Hypokalemia and dehydration
Which anticoagulant is contraindicated in pregnancy due to teratogenicity?
✔✔ Warfarin
Which class of medications can cause weight gain and fluid retention?
✔✔ Corticosteroids
Which medication is contraindicated in patients with severe liver impairment?
✔✔ Acetaminophen in high doses
What is a common side effect of SSRIs such as sertraline?
✔✔ Nausea, insomnia, and sexual dysfunction
3
, Which drug can interact with grapefruit juice, leading to increased plasma levels?
✔✔ Statins and certain calcium channel blockers
Which antihypertensive class can cause reflex tachycardia if stopped abruptly?
✔✔ Beta-blockers
Which NSAID can increase the risk of gastrointestinal bleeding when taken with anticoagulants?
✔✔ Ibuprofen
Which drug is contraindicated in patients with history of sulfa allergy?
✔✔ Sulfonamide antibiotics
Which medication may cause peripheral edema as a side effect?
✔✔ Calcium channel blockers
Which drug interaction can occur between lithium and thiazide diuretics?
✔✔ Increased risk of lithium toxicity
4
