Biopharmaceutics (Green PACOP)
Questions and Answers | Latest
Version | 2025/2026 | Correct & Verified
Which pharmacokinetic phase involves the movement of drug from the site of administration
into the bloodstream?
a. Distribution
✔✔ b. Absorption
c. Metabolism
d. Elimination
The process by which a drug is converted into more water-soluble metabolites is:
a. Absorption
b. Distribution
✔✔ c. Biotransformation
d. Excretion
Which pharmacokinetic parameter represents the total extent of drug exposure in plasma over
time?
1
,a. Cmax
✔✔ b. AUC
c. Tmax
d. Kel
What does bioavailability refer to?
a. Drug binding to plasma proteins
b. Rate of renal clearance
✔✔ c. Fraction of administered drug reaching systemic circulation
d. Degree of drug metabolism in the liver
Which is the primary organ of drug metabolism?
a. Kidney
✔✔ b. Liver
c. Lungs
d. Spleen
Which order of kinetics is most common for therapeutic drugs at normal concentrations?
2
,✔✔ a. First-order
b. Zero-order
c. Saturable
d. Mixed-order
If two drug formulations produce superimposable plasma concentration–time curves, they are
considered:
a. Therapeutically equivalent
✔✔ b. Bioequivalent
c. Pharmacologically antagonistic
d. Biotransformed
What does Cmax indicate in a plasma concentration–time profile?
✔✔ a. Peak plasma concentration
b. Half-life of the drug
c. Rate of renal clearance
d. Total body exposure
3
, Which factor delays gastric emptying and reduces drug absorption rate?
✔✔ a. High-fat meals
b. Water intake
c. Fasting state
d. Alkaline urine
Which route of administration avoids first-pass metabolism?
a. Oral
b. Rectal (upper part)
✔✔ c. Sublingual
d. Gastric
The plasma half-life (t½) of a drug primarily depends on:
a. Absorption rate
✔✔ b. Clearance and volume of distribution
c. Bioavailability
d. Protein binding only
4
Questions and Answers | Latest
Version | 2025/2026 | Correct & Verified
Which pharmacokinetic phase involves the movement of drug from the site of administration
into the bloodstream?
a. Distribution
✔✔ b. Absorption
c. Metabolism
d. Elimination
The process by which a drug is converted into more water-soluble metabolites is:
a. Absorption
b. Distribution
✔✔ c. Biotransformation
d. Excretion
Which pharmacokinetic parameter represents the total extent of drug exposure in plasma over
time?
1
,a. Cmax
✔✔ b. AUC
c. Tmax
d. Kel
What does bioavailability refer to?
a. Drug binding to plasma proteins
b. Rate of renal clearance
✔✔ c. Fraction of administered drug reaching systemic circulation
d. Degree of drug metabolism in the liver
Which is the primary organ of drug metabolism?
a. Kidney
✔✔ b. Liver
c. Lungs
d. Spleen
Which order of kinetics is most common for therapeutic drugs at normal concentrations?
2
,✔✔ a. First-order
b. Zero-order
c. Saturable
d. Mixed-order
If two drug formulations produce superimposable plasma concentration–time curves, they are
considered:
a. Therapeutically equivalent
✔✔ b. Bioequivalent
c. Pharmacologically antagonistic
d. Biotransformed
What does Cmax indicate in a plasma concentration–time profile?
✔✔ a. Peak plasma concentration
b. Half-life of the drug
c. Rate of renal clearance
d. Total body exposure
3
, Which factor delays gastric emptying and reduces drug absorption rate?
✔✔ a. High-fat meals
b. Water intake
c. Fasting state
d. Alkaline urine
Which route of administration avoids first-pass metabolism?
a. Oral
b. Rectal (upper part)
✔✔ c. Sublingual
d. Gastric
The plasma half-life (t½) of a drug primarily depends on:
a. Absorption rate
✔✔ b. Clearance and volume of distribution
c. Bioavailability
d. Protein binding only
4
