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NR 568
NR 548 Midterm Exam: (Latest Update 2025 /
2026) | Questions & Answers | Grade A 100%
Correct.
1. Azoles: itraconazole (Sporanox) - Mechanism of Action: Inhibits the
synthesis of ergosterol (sterol), resulting in increased membrane
permeability and leakage of cellular components.
2. Azoles: itraconazole (Sporanox) - Adverse Effects: GI upset, Cardiac
suppression, Hepatic injury
3. Azoles: itraconazole (Sporanox) - Precautions: Hepatic dysfunction, Heart
failure
4. Azoles: itraconazole (Sporanox) - Interactions: PPIs, CYP3A4 inhibitors
5. Azoles: itraconazole (Sporanox) - Education: Take with food/cola
6. Azoles: itraconazole (Sporanox) - Labs: BMP, Coagulation, Serum Drug Levels
7. Echinocandins: caspofungin (Cancidas): Antifungal: aspergillus and candida
infections
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8. Echinocandins: caspofungin (Cancidas) - Mechanism of Action: Inhibits the
biosynthesis of beta-1,3-d-glucan, an essential fungal cell wall component.
9. Echinocandins: caspofungin (Cancidas) - Adverse Effects: Histamine-
mediated reactions, Injection site reactions
10. Echinocandins: caspofungin (Cancidas) - Precautions: Embryotoxic,
Hepatic impairment
11. Echinocandins: caspofungin (Cancidas) - Interactions: Drugs that induce
CYP450 enzymes, tacrolimus, cyclosporine
12. Echinocandins: caspofungin (Cancidas) - Education: IV administration
13. Echinocandins: caspofungin (Cancidas) - Labs: LFTs, Serum Drug Levels
14. Pyrimidines: flucytosine (Ancobon): Antifungal: Candida and C.
neoformans
15. Pyrimidines: flucytosine (Ancobon) - Mechanism of Action: Taken
up by fungal cells
and converted to the powerful antimetabolite 5-fluorouracil (5-FU). These
metabolites disrupt fungal DNA and RNA synthesis.
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16. Pyrimidines: flucytosine (Ancobon) - Adverse Effects: Hematologic effects,
Hepatotoxicity
17. Pyrimidines: flucytosine (Ancobon) - Precautions: Renal Impairment,
Hematologic disorders, Bone Marrow suppression
18. Pyrimidines: flucytosine (Ancobon) - Interactions: amphotericin b,
cisapride, pimozide, dofetilide, quinidine
26. Pyrimidines: flucytosine (Ancobon) - Dose: 50 - 150 mg/kg/day
administered in four divided doses at 6-hour intervals.
27. Pyrimidines: flucytosine (Ancobon) - Labs: BMP, CBC, LFTs, Serum Drug
Levels
28. Allylamines: terbinafine (Lamisil): Antifungal: tinea and onycho-mycosis
29. Allylamines: terbinafine (Lamisil) - Mechanism of Action: Inhibits
squalene epoxidase with resultant inhibition of ergosterol synthesis.
30. Allylamines: terbinafine (Lamisil) - Adverse Effects: GI upset, Skin
reactions, Altered taste, Hepatotoxicity
31. Allylamines: terbinafine (Lamisil) - Precautions: Hepatic disease
NR 568
NR 568
NR 548 Midterm Exam: (Latest Update 2025 /
2026) | Questions & Answers | Grade A 100%
Correct.
1. Azoles: itraconazole (Sporanox) - Mechanism of Action: Inhibits the
synthesis of ergosterol (sterol), resulting in increased membrane
permeability and leakage of cellular components.
2. Azoles: itraconazole (Sporanox) - Adverse Effects: GI upset, Cardiac
suppression, Hepatic injury
3. Azoles: itraconazole (Sporanox) - Precautions: Hepatic dysfunction, Heart
failure
4. Azoles: itraconazole (Sporanox) - Interactions: PPIs, CYP3A4 inhibitors
5. Azoles: itraconazole (Sporanox) - Education: Take with food/cola
6. Azoles: itraconazole (Sporanox) - Labs: BMP, Coagulation, Serum Drug Levels
7. Echinocandins: caspofungin (Cancidas): Antifungal: aspergillus and candida
infections
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, 2
NR 568
8. Echinocandins: caspofungin (Cancidas) - Mechanism of Action: Inhibits the
biosynthesis of beta-1,3-d-glucan, an essential fungal cell wall component.
9. Echinocandins: caspofungin (Cancidas) - Adverse Effects: Histamine-
mediated reactions, Injection site reactions
10. Echinocandins: caspofungin (Cancidas) - Precautions: Embryotoxic,
Hepatic impairment
11. Echinocandins: caspofungin (Cancidas) - Interactions: Drugs that induce
CYP450 enzymes, tacrolimus, cyclosporine
12. Echinocandins: caspofungin (Cancidas) - Education: IV administration
13. Echinocandins: caspofungin (Cancidas) - Labs: LFTs, Serum Drug Levels
14. Pyrimidines: flucytosine (Ancobon): Antifungal: Candida and C.
neoformans
15. Pyrimidines: flucytosine (Ancobon) - Mechanism of Action: Taken
up by fungal cells
and converted to the powerful antimetabolite 5-fluorouracil (5-FU). These
metabolites disrupt fungal DNA and RNA synthesis.
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16. Pyrimidines: flucytosine (Ancobon) - Adverse Effects: Hematologic effects,
Hepatotoxicity
17. Pyrimidines: flucytosine (Ancobon) - Precautions: Renal Impairment,
Hematologic disorders, Bone Marrow suppression
18. Pyrimidines: flucytosine (Ancobon) - Interactions: amphotericin b,
cisapride, pimozide, dofetilide, quinidine
26. Pyrimidines: flucytosine (Ancobon) - Dose: 50 - 150 mg/kg/day
administered in four divided doses at 6-hour intervals.
27. Pyrimidines: flucytosine (Ancobon) - Labs: BMP, CBC, LFTs, Serum Drug
Levels
28. Allylamines: terbinafine (Lamisil): Antifungal: tinea and onycho-mycosis
29. Allylamines: terbinafine (Lamisil) - Mechanism of Action: Inhibits
squalene epoxidase with resultant inhibition of ergosterol synthesis.
30. Allylamines: terbinafine (Lamisil) - Adverse Effects: GI upset, Skin
reactions, Altered taste, Hepatotoxicity
31. Allylamines: terbinafine (Lamisil) - Precautions: Hepatic disease
NR 568
