MDT EXAM 1 - PART 1 QUESTIONS & ANSWERS!!
discuss the impact of molecular diagnostics in human disease Answer - More
accurate disease monitoring - allows for early treatment and improved patient
care
Determination of most appropriate treatment
Reduction of patient morbidity and mortality
Able to diagnose and prognosis that patient
*** Example someone might have a HER2 gene amplification but we have a
great medication to use despite the fact that this type of breast cancer is
aggressive
define molecular diagnostics Answer - - Molecular diagnostics encompasses
the use of molecular biology techniques to expand scientific knowledge of the
natural history of disease
- Can help identify people at risk for acquiring specific diseases and facilitates
the diagnosis of infectious and other human diseases at the nucleic level
- Molecular testing went from being its own thing to being a part of many lab
practices
, importance of nucleic acids in the lab Answer - -Assay exhibit extreme
sensitivity and specificity (which can be controlled)
-Genotype before phenotype
-Targets can be amplified >10^6 --- assays like a photocopier so we can find the
targets we are interested in
describe utility of molecular pathology in laboratory medicine Answer - -
Assays are developed based on the presence of specific molecular markers
-Diagnostic test -- distinguish variations in human disease
- Prognostic tests -- accurately describe the course of disease
- Therapeutic tests -- predict the response to specific therapies and determine
if therapy is effective
list applications for genomic technologies Answer - Molecular diagnostics is a
universal discipline of laboratory medicine
Genetics - heritable diseases
Oncology - solid tumors
Hematopathology - leukemia and lymphoma
Identity Testing - transplantation and forensics
discuss the impact of molecular diagnostics in human disease Answer - More
accurate disease monitoring - allows for early treatment and improved patient
care
Determination of most appropriate treatment
Reduction of patient morbidity and mortality
Able to diagnose and prognosis that patient
*** Example someone might have a HER2 gene amplification but we have a
great medication to use despite the fact that this type of breast cancer is
aggressive
define molecular diagnostics Answer - - Molecular diagnostics encompasses
the use of molecular biology techniques to expand scientific knowledge of the
natural history of disease
- Can help identify people at risk for acquiring specific diseases and facilitates
the diagnosis of infectious and other human diseases at the nucleic level
- Molecular testing went from being its own thing to being a part of many lab
practices
, importance of nucleic acids in the lab Answer - -Assay exhibit extreme
sensitivity and specificity (which can be controlled)
-Genotype before phenotype
-Targets can be amplified >10^6 --- assays like a photocopier so we can find the
targets we are interested in
describe utility of molecular pathology in laboratory medicine Answer - -
Assays are developed based on the presence of specific molecular markers
-Diagnostic test -- distinguish variations in human disease
- Prognostic tests -- accurately describe the course of disease
- Therapeutic tests -- predict the response to specific therapies and determine
if therapy is effective
list applications for genomic technologies Answer - Molecular diagnostics is a
universal discipline of laboratory medicine
Genetics - heritable diseases
Oncology - solid tumors
Hematopathology - leukemia and lymphoma
Identity Testing - transplantation and forensics
