- Neuromuscular Transmission & E-C Coupling
Neurotransmitter containing
vesicles
EPP same as EPSP
Cannot see the EPP when you record away
from the end plate
EPP only local to trigger action potential for
the rest of the fibre
After it is taken back into
Acetylcholine is the presynaptic terminal-
released from a
It is recycled back into the
motor axon
acetylcholine by acetyl CoA
Acts on ligand gated
Na+ channels
Broken down in the cleft to choline and acetate by AChE,
to prevent CONSTANT STIMULATION
The activation of post synaptic nicotinic receptors causes an end plate potential that triggers a
propagating muscle fibre action potential