USMLE RX SELF-ASSESSMENT ANALYST EXAM QUESTIONS & CORRECT ANSWERS ACED RESULTS

USMLE RX SELF-ASSESSMENT ANALYST EXAM
QUESTIONS & CORRECT ANSWERS ACED RESULTS


Patients with Chronic Granulomatous Disease (CGD) have an increased susceptibility to what
organisms? - CORRECT ANSWER >>>-Catalase positive organisms



-CATs Need PLACESS to Belch their Hairballs



-CAT +

-Nocardia

-Pseudomonas

-Listeria

-Aspergillus

-Candida

-E. coli

-Staphylococcus

-Serratia

-Burkholderia cepacia

-H. pylori



What enzyme is deficient in patients with CGD? - CORRECT ANSWER >>>NADPH oxidase



Chronic Granulomatous Disease (CGD) - CORRECT ANSWER >>>defect in NADPH oxidase →
↑ susceptibility to infections with catalase + organisms

Impaired respiratory burst in neutrophils


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,Abnormal flow cytometry test (decreased green fluorescence)



Nitroblue tetrazolium dye reaction test fails to turn blue



What two tests can be used to diagnose CGD? - CORRECT ANSWER >>>1. Dihydrorhodaomine
(flow cytometry) test will show reduced fluorescence



2. Nitroblue tetrazolium dye reduction test; will fail to turn blue



What is the most common inheritance pattern for CGD? - CORRECT ANSWER >>>X-linked
recessive



More common in boys



vEDS is caused by pathogenic mutations in the ________________ gene - CORRECT ANSWER
>>>COL3A1 gene



encodes collagen type III alpha chain



________________ collagen is a fibril-forming collagen essential for mechanical strength and
elasticity of expansible tissues. - CORRECT ANSWER >>>Type III



The treatment of choice for Pneumocytis pneumonia is - CORRECT ANSWER
>>>trimethoprim-sulfamethoxazole

Terbinafine inhibits the fungal enzyme _______________________ and is used to treat
dermatophytoses - CORRECT ANSWER >>>squalene epoxidase


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,Pneumocystis pneumonia - CORRECT ANSWER >>>-caused by Pneumocytis jirovecii

-diffuse interstitial pneumonia



-Yeast-like fungus

-Disc-shaped yeast on methenamine silver stain



-Immunosuppression predisposes to disease



-Diffuse bilateral ground-glass opacities on chest imagine, with pneumatoceles



-Treatment/ Prophylaxis: TMP-SMX, pentamidine, dapsone, atovaquone



Pneumocytis pneumonia prophylaxis with TMP-SMX should be started in patients with HIV
infection with CD4 counts < _____________ - CORRECT ANSWER >>>< 200 cells/mm3



McArdle Disease - CORRECT ANSWER >>>-deficiency in myophosphorylase



-glycogen storage disease type V



-muscle cramps with exercise, red-colored urine due to myoglobinuria



-no increase in lactate

-Elevated CK




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, Myophosphorylase deficiency results from pathogenic mutations in the ___________ gene -
CORRECT ANSWER >>>PYGM gene —> encodes myophosphorylase



Myophosphorylase - CORRECT ANSWER >>>-Deficient in McArdle Disease (Type V)



-Liberates glucose-1-phosphate units from glycogen



alpha-1,6-glucosidase is one of the two catalytic activities of the debraching enzyme, which
liberates glucose from glycogen branch-points. Deficiency in this enzyme causes
____________________________ - CORRECT ANSWER >>>Cori Disease



-Hypoglycemia



-Increased liver glycogen



-Hepatomegaly



-Normal lactate



-No muscle cramping



PYGM gene mutation - CORRECT ANSWER >>>-Results in McArdle Disease (Type V)



-Myophosphorylase deficiency

Tinea versicolor, also called pityriasis versicolor, is caused by _____________________ infection
and most often occurs on the upper back or chest. - CORRECT ANSWER >>>Malassezia furfur



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