TEST BANK
BIOCHEMISTRY: CONCEPTS & CONNECTIONS
Page | 1
, Chapter 1 Biochemistry And The Language Of Chemistry
1) The Water Content In The Human Body Is Approximately :
A) 90%.
B) 80%.
C) 70%.
D) 60%.
E) 50%.
Answer: C
2) The Four Most Abundant Chemical Elements In Living Systems Are :
A) Hydrogen, Oxygen, Sulfur And Phosphorus.
B) Hydrogen, Carbon, Nitrogen And Oxygen.
C) Sodium, Potassium, Carbon And Oxygen.
D) Sodium, Potassium, Nitrogen And Sulfur.
E) Carbon, Nitrogen, Oxygen And Potassium. Answer: B
Objective: 1.2
3) Nearly All Proteins Contain :
A) Cobalt.
B) Phosphorus.
C) Selenium.
D) Sulfur.
E) None Of The Above. Answer: D Objective: 1.2 Global Lo: G7
4) Which Of The Following Statements Is False?
A) Proteins Can Be Structural Components Of Cells.
Page | 2
,B) Proteins Can Transmit Signals Between Cells.
C) Proteins Can Transport Molecules Within Cells And Between Cells.
D) Proteins Can Be Both Hormones And Hormone Receptors.
E) Proteins Are The Only Biological Polymer That Can Catalyze Biochemical Reactions.
Answer: E
Objective: 1.2 Global Lo: G7
5) Which Of The Following Is Not Classed As A Lipid?
A) Cholesterol
B) Palmitic Acid
C) Glycerol
D) Phosphatidyl Serine
E) Triacylglycerol Answer: C Objective: 1.2 Global Lo: G7
6) Amino Acids And Simple Organic Compounds Like Carbon Dioxide And Hydrogen Cyanide
Cannot Be Produced Without The Use Of Enzymes.
Answer: False Objective: 1.2 Global Lo: G7
7) Oxidation-Reduction Reactions, Which Are The Basis Of Many Biochemical Reactions And
Pathways, Cannot Take Place In The Absence Of Oxygen.
Answer: False Objective: 1.2 Global Lo: G7
8) Many Biochemical Reactions That Form Biopolymers From Monomeric Units Involve The
Removal Of Water.
Answer: True Objective: 1.2 Global Lo: G7
9) The Principle Component Of A Biological Membrane Is A Triglyceride. Answer: False
Objective: 1.2 Global Lo: G7
Page | 3
,10) The Chemical Element Has A Role In Both Transfer Of Energy As Well As In The Structure Of
Nucleic Acids.
Answer: Phosphorus Objective: 1.2 Global Lo: G7
11) List The Four Major Classes Of Biological Macromolecules. Answer: Lipids, Carbohydrates,
Proteins, Nucleic Acids Objective: 1.2
Global Lo: G7
12) An Amphipathic Molecule Provides The Foundation For Biological Membranes Because They
Have Both And Functional Groups.
Answer: Hydrophobic, Hydrophilic Objective: 1.2 Global
Lo: G7
13) Genomics Is Concerned With The Entire , While Is Focused On Identifying All Of The Proteins
Of A Cell.
Answer: Genome, Proteomics Objective: 1.5 Global Lo:
G1
Page | 4
, Chapter 2 The Chemical Foundation Of Life: Weak Interactions In An Aqueous
Environment
1) Each Of The Following Is A Non-Covalent Interaction Except :
A) A Hydrogen Bond.
B) A Carbon-Hydrogen Bond.
C) The Interaction Between An Amino And A Carboxylate Group.
D) A Van Der Waals Interaction.
E) An Interaction Between —Nh3+ And A Water Molecule. Answer: B
Objective: 2.1 Global Lo: G7
2) The Most Important Non-Covalent Interaction In Biochemistry Is The Bond. Answer:
Hydrogen
Objective: 2.1 Global Lo: G7
3) Which Of The Following Is False When Considering Van Der Waals Interactions?
A) The Van Der Waals Radius Represents The Most Stable Distance Between Two Interacting
Centers.
B) Van Der Waals Radii Can Determine Molecular Surfaces.
C) Molecules That Interact By Van Der Waals Forces Do Not Interpenetrate.
D) The Total Interaction Energy Is The Sum Of The Attractive And Repulsive Forces.
E) They Are Not Important In Determining The Stability Of Three-Dimensional Structures Of
Proteins. Answer: E
Objective: 2.2 Global Lo: G2
4) Which Of The Following In Biological Compounds Are Sufficiently Electronegative To Serve As
Strong Donors In A Hydrogen Bond?
A) Hydrogen And Oxygen
B) Oxygen And Nitrogen
C) Nitrogen And Hydrogen
D) Hydrogen And Carbon
Page | 5
,E) Nitrogen And Carbon Answer: B
Objective: 2.2 Global Lo: G7
5) Hydrogen Bonds Share Features Of Both Covalent And Non-Covalent Bonds.
Answer: True Objective: 2.2 Global Lo: G2
6) Which Of The Following Is True Of Hydrophobic Molecules?
A) They Have Limited Solubility In Water.
B) Water Forms A Cage-Like Structure Around Them.
C) Dissolving In Water Decreases The Entropy Of The Mixture.
D) They Self-Associate By Releasing Some Of The Surrounding Water Molecules.
E) All Of The Above Answer: E Objective: 2.3 Global Lo: G2
7) Water Is Both A Hydrogen Bond Donor And Acceptor. Answer: True
Objective: 2.3 Global Lo: G2
8) Amphipathic Molecules Are Not Able To Interact Via Van Der Waals Forces. Answer: False
Objective: 2.3 Global Lo: G2
9) Ionic Compounds Can Be Readily Dissolved In Water Because The High Dielectric Constant
Of Water Screens And Decreases The Force Between The Oppositely Charged Ions. Answer:
Electrostatic
Objective: 2.3 Global Lo: G7
10) The Describes The Tendency For Hydrophobic Molecules To Aggregate Because Of The
Exclusion Of Water With The Consequent Increase Of Entropy Of The Solvent.
Answer: Hydrophobic Effect Objective: 2.3 Global
Lo: G7
Page | 6
,11) Glycine Cannot Serve As A Buffer Because It Has Two Ionizable Groups. Answer: False
Objective: 2.4 Global Lo: G7
12) The Average Charge On An Amino Acid Below Its Pi Will Be Positive. Answer: True
Objective: 2.4 Global Lo: G2
13) Calculate The Acid Dissociation Constant Ka Of A 0.2 M Solution Of Weak Acid That Is 0.1%
Ionized.
Answer: 2 × 10-7
Objective: 2.4 Global Lo: G4
14) Calculate The Ph Of A 0.1 M Phosphate Buffer (Pka = 6.86) That Contains Equal Amounts Of
Acid And Conjugate Base.
Answer: 6.86 Objective: 2.4
Global Lo: G4
15) Calculate The Ph Of A 0.2 M Acetate Buffer (Pka = 4.77) That Contains Twice As Much Acid As
Conjugate Base. Answer: 4.47
Objective: 2.4 Global Lo: G4
16) The Pka Of Each Amino Acid Residue In A Protein Will Not Be Influenced By The Adjacent Residue.
Answer: False Objective: 2.5 Global Lo: G2
17) Calculate The Ph At The End Of An Enzyme-Catalyzed Reaction If It Were Carried Out In A 0.1 M
Phosphate Buffer, Ph 6.86 And 0.005 M Of Acid Was Produced During The Reaction? Answer: 6.77
Objective: 2.5 Global Lo: G4
18) If Hydroxide Is Added To An Amino Acid It Will Become Increasingly Charged. Answer:
Negatively
Page | 7
,Objective: 2.6 Global Lo: G7
19) Calculate The Ph Of A Weak Acid That Is 0.2% Ionized In A 0.2 M Solution. Answer: 3.39
Objective: 2.6 Global Lo: G4
20) The Net Charge On An Amino Acid At Its Isoelectric Point (Pi) Is . Answer: Zero
Objective: 2.7 Global Lo: G7
21) Many Proteins Interact With Dna At Physiological Ph Because :
A) Proteins Are Naturally Attracted To Dna Regardless Of The Ph.
B) The Negatively Charged Dna Is Electrostatically Attracted To Positively Charged
Regions On Proteins.
C) The Positively Charged Dna Is Electrostatically Attracted To Negatively Charged
Regions On Proteins.
D) Proteins And Dna Interact Using Mainly Hydrophobic Interactions.
E) Both Proteins And Dna Are At Their Isoelectric Points At Physiological Ph And Tend To
Aggregate. Answer: B
Objective: 2.8 Global Lo: G2
22) Small Ions In Biological Fluids :
A) Encourage Strong Electrostatic Interactions Between Oppositely Charged Macroions At Low
Ionic Strengths.
B) Encourage Strong Electrostatic Interactions Between Oppositely Charged Macroions At High
Ionic Strengths.
C) Have No Effect On The Interactions Between Oppositely Charged Macroions.
D) Tend To Cluster Around Macroions Of The Same Charge.
E) Have Large Effects On Ph. Answer: A
Objective: 2.8 Global Lo: G7
Page | 8
, Chapter 3 The Energetics Of Life
1) Which Of The Following Statements Is False?
A) Organisms Are Open Systems As They Can Exchange Both Energy And Materials
With Their Environments.
B) In An Open System Energy Can Be Converted From One Form Into Another.
C) Organisms Are Open Systems As They Can Create Energy From Their Environments.
D) Energy Can Be Transferred Between A System And The Surroundings.
Page | 9
, E) In Biochemical Processes, Energy Can Neither Be Created Or Destroyed. Answer: C
Objective: 3.1 Global Lo: G7
2) Which Of The Following Statements Is False?
A) Entropy Is A Measure Of Disorder.
B) The Entropy Of An Isolated System Will Tend To Increase To A Maximum Value.
C) Biological Systems Are Highly Ordered So Entropy Changes Are Not Relevant.
D) Biological Systems Expend Energy To Overcome Entropy.
E) The Entropy Of A Biological System Can Decrease. Answer: C
Objective: 3.2 Global Lo: G2
3) A Biochemical Reaction Will Proceed In The Direction As Written If :
A) △G = Zero.
B) △G > 0.
C) △G < 0.
D) △H > 0.
E) △H < 0.
Answer: C Objective: 3.2 Global Lo: G2
4) Life Is An Irreversible Process, Such That It Never Comes To Equilibrium. Answer: True
Objective: 3.2 Global Lo: G2
5) The Equilibrium Constant Of A Reaction :
A) Is Not Related To The Change In Free Energy Of The Reaction.
B) Is The Same As The Mass Action Ratio When The Reaction Is Displaced From Equilibrium.
C) Can Change If The Concentration Of Reactants And Products Are Changed.
Page | 10
BIOCHEMISTRY: CONCEPTS & CONNECTIONS
Page | 1
, Chapter 1 Biochemistry And The Language Of Chemistry
1) The Water Content In The Human Body Is Approximately :
A) 90%.
B) 80%.
C) 70%.
D) 60%.
E) 50%.
Answer: C
2) The Four Most Abundant Chemical Elements In Living Systems Are :
A) Hydrogen, Oxygen, Sulfur And Phosphorus.
B) Hydrogen, Carbon, Nitrogen And Oxygen.
C) Sodium, Potassium, Carbon And Oxygen.
D) Sodium, Potassium, Nitrogen And Sulfur.
E) Carbon, Nitrogen, Oxygen And Potassium. Answer: B
Objective: 1.2
3) Nearly All Proteins Contain :
A) Cobalt.
B) Phosphorus.
C) Selenium.
D) Sulfur.
E) None Of The Above. Answer: D Objective: 1.2 Global Lo: G7
4) Which Of The Following Statements Is False?
A) Proteins Can Be Structural Components Of Cells.
Page | 2
,B) Proteins Can Transmit Signals Between Cells.
C) Proteins Can Transport Molecules Within Cells And Between Cells.
D) Proteins Can Be Both Hormones And Hormone Receptors.
E) Proteins Are The Only Biological Polymer That Can Catalyze Biochemical Reactions.
Answer: E
Objective: 1.2 Global Lo: G7
5) Which Of The Following Is Not Classed As A Lipid?
A) Cholesterol
B) Palmitic Acid
C) Glycerol
D) Phosphatidyl Serine
E) Triacylglycerol Answer: C Objective: 1.2 Global Lo: G7
6) Amino Acids And Simple Organic Compounds Like Carbon Dioxide And Hydrogen Cyanide
Cannot Be Produced Without The Use Of Enzymes.
Answer: False Objective: 1.2 Global Lo: G7
7) Oxidation-Reduction Reactions, Which Are The Basis Of Many Biochemical Reactions And
Pathways, Cannot Take Place In The Absence Of Oxygen.
Answer: False Objective: 1.2 Global Lo: G7
8) Many Biochemical Reactions That Form Biopolymers From Monomeric Units Involve The
Removal Of Water.
Answer: True Objective: 1.2 Global Lo: G7
9) The Principle Component Of A Biological Membrane Is A Triglyceride. Answer: False
Objective: 1.2 Global Lo: G7
Page | 3
,10) The Chemical Element Has A Role In Both Transfer Of Energy As Well As In The Structure Of
Nucleic Acids.
Answer: Phosphorus Objective: 1.2 Global Lo: G7
11) List The Four Major Classes Of Biological Macromolecules. Answer: Lipids, Carbohydrates,
Proteins, Nucleic Acids Objective: 1.2
Global Lo: G7
12) An Amphipathic Molecule Provides The Foundation For Biological Membranes Because They
Have Both And Functional Groups.
Answer: Hydrophobic, Hydrophilic Objective: 1.2 Global
Lo: G7
13) Genomics Is Concerned With The Entire , While Is Focused On Identifying All Of The Proteins
Of A Cell.
Answer: Genome, Proteomics Objective: 1.5 Global Lo:
G1
Page | 4
, Chapter 2 The Chemical Foundation Of Life: Weak Interactions In An Aqueous
Environment
1) Each Of The Following Is A Non-Covalent Interaction Except :
A) A Hydrogen Bond.
B) A Carbon-Hydrogen Bond.
C) The Interaction Between An Amino And A Carboxylate Group.
D) A Van Der Waals Interaction.
E) An Interaction Between —Nh3+ And A Water Molecule. Answer: B
Objective: 2.1 Global Lo: G7
2) The Most Important Non-Covalent Interaction In Biochemistry Is The Bond. Answer:
Hydrogen
Objective: 2.1 Global Lo: G7
3) Which Of The Following Is False When Considering Van Der Waals Interactions?
A) The Van Der Waals Radius Represents The Most Stable Distance Between Two Interacting
Centers.
B) Van Der Waals Radii Can Determine Molecular Surfaces.
C) Molecules That Interact By Van Der Waals Forces Do Not Interpenetrate.
D) The Total Interaction Energy Is The Sum Of The Attractive And Repulsive Forces.
E) They Are Not Important In Determining The Stability Of Three-Dimensional Structures Of
Proteins. Answer: E
Objective: 2.2 Global Lo: G2
4) Which Of The Following In Biological Compounds Are Sufficiently Electronegative To Serve As
Strong Donors In A Hydrogen Bond?
A) Hydrogen And Oxygen
B) Oxygen And Nitrogen
C) Nitrogen And Hydrogen
D) Hydrogen And Carbon
Page | 5
,E) Nitrogen And Carbon Answer: B
Objective: 2.2 Global Lo: G7
5) Hydrogen Bonds Share Features Of Both Covalent And Non-Covalent Bonds.
Answer: True Objective: 2.2 Global Lo: G2
6) Which Of The Following Is True Of Hydrophobic Molecules?
A) They Have Limited Solubility In Water.
B) Water Forms A Cage-Like Structure Around Them.
C) Dissolving In Water Decreases The Entropy Of The Mixture.
D) They Self-Associate By Releasing Some Of The Surrounding Water Molecules.
E) All Of The Above Answer: E Objective: 2.3 Global Lo: G2
7) Water Is Both A Hydrogen Bond Donor And Acceptor. Answer: True
Objective: 2.3 Global Lo: G2
8) Amphipathic Molecules Are Not Able To Interact Via Van Der Waals Forces. Answer: False
Objective: 2.3 Global Lo: G2
9) Ionic Compounds Can Be Readily Dissolved In Water Because The High Dielectric Constant
Of Water Screens And Decreases The Force Between The Oppositely Charged Ions. Answer:
Electrostatic
Objective: 2.3 Global Lo: G7
10) The Describes The Tendency For Hydrophobic Molecules To Aggregate Because Of The
Exclusion Of Water With The Consequent Increase Of Entropy Of The Solvent.
Answer: Hydrophobic Effect Objective: 2.3 Global
Lo: G7
Page | 6
,11) Glycine Cannot Serve As A Buffer Because It Has Two Ionizable Groups. Answer: False
Objective: 2.4 Global Lo: G7
12) The Average Charge On An Amino Acid Below Its Pi Will Be Positive. Answer: True
Objective: 2.4 Global Lo: G2
13) Calculate The Acid Dissociation Constant Ka Of A 0.2 M Solution Of Weak Acid That Is 0.1%
Ionized.
Answer: 2 × 10-7
Objective: 2.4 Global Lo: G4
14) Calculate The Ph Of A 0.1 M Phosphate Buffer (Pka = 6.86) That Contains Equal Amounts Of
Acid And Conjugate Base.
Answer: 6.86 Objective: 2.4
Global Lo: G4
15) Calculate The Ph Of A 0.2 M Acetate Buffer (Pka = 4.77) That Contains Twice As Much Acid As
Conjugate Base. Answer: 4.47
Objective: 2.4 Global Lo: G4
16) The Pka Of Each Amino Acid Residue In A Protein Will Not Be Influenced By The Adjacent Residue.
Answer: False Objective: 2.5 Global Lo: G2
17) Calculate The Ph At The End Of An Enzyme-Catalyzed Reaction If It Were Carried Out In A 0.1 M
Phosphate Buffer, Ph 6.86 And 0.005 M Of Acid Was Produced During The Reaction? Answer: 6.77
Objective: 2.5 Global Lo: G4
18) If Hydroxide Is Added To An Amino Acid It Will Become Increasingly Charged. Answer:
Negatively
Page | 7
,Objective: 2.6 Global Lo: G7
19) Calculate The Ph Of A Weak Acid That Is 0.2% Ionized In A 0.2 M Solution. Answer: 3.39
Objective: 2.6 Global Lo: G4
20) The Net Charge On An Amino Acid At Its Isoelectric Point (Pi) Is . Answer: Zero
Objective: 2.7 Global Lo: G7
21) Many Proteins Interact With Dna At Physiological Ph Because :
A) Proteins Are Naturally Attracted To Dna Regardless Of The Ph.
B) The Negatively Charged Dna Is Electrostatically Attracted To Positively Charged
Regions On Proteins.
C) The Positively Charged Dna Is Electrostatically Attracted To Negatively Charged
Regions On Proteins.
D) Proteins And Dna Interact Using Mainly Hydrophobic Interactions.
E) Both Proteins And Dna Are At Their Isoelectric Points At Physiological Ph And Tend To
Aggregate. Answer: B
Objective: 2.8 Global Lo: G2
22) Small Ions In Biological Fluids :
A) Encourage Strong Electrostatic Interactions Between Oppositely Charged Macroions At Low
Ionic Strengths.
B) Encourage Strong Electrostatic Interactions Between Oppositely Charged Macroions At High
Ionic Strengths.
C) Have No Effect On The Interactions Between Oppositely Charged Macroions.
D) Tend To Cluster Around Macroions Of The Same Charge.
E) Have Large Effects On Ph. Answer: A
Objective: 2.8 Global Lo: G7
Page | 8
, Chapter 3 The Energetics Of Life
1) Which Of The Following Statements Is False?
A) Organisms Are Open Systems As They Can Exchange Both Energy And Materials
With Their Environments.
B) In An Open System Energy Can Be Converted From One Form Into Another.
C) Organisms Are Open Systems As They Can Create Energy From Their Environments.
D) Energy Can Be Transferred Between A System And The Surroundings.
Page | 9
, E) In Biochemical Processes, Energy Can Neither Be Created Or Destroyed. Answer: C
Objective: 3.1 Global Lo: G7
2) Which Of The Following Statements Is False?
A) Entropy Is A Measure Of Disorder.
B) The Entropy Of An Isolated System Will Tend To Increase To A Maximum Value.
C) Biological Systems Are Highly Ordered So Entropy Changes Are Not Relevant.
D) Biological Systems Expend Energy To Overcome Entropy.
E) The Entropy Of A Biological System Can Decrease. Answer: C
Objective: 3.2 Global Lo: G2
3) A Biochemical Reaction Will Proceed In The Direction As Written If :
A) △G = Zero.
B) △G > 0.
C) △G < 0.
D) △H > 0.
E) △H < 0.
Answer: C Objective: 3.2 Global Lo: G2
4) Life Is An Irreversible Process, Such That It Never Comes To Equilibrium. Answer: True
Objective: 3.2 Global Lo: G2
5) The Equilibrium Constant Of A Reaction :
A) Is Not Related To The Change In Free Energy Of The Reaction.
B) Is The Same As The Mass Action Ratio When The Reaction Is Displaced From Equilibrium.
C) Can Change If The Concentration Of Reactants And Products Are Changed.
Page | 10
