ANCC Practice Questions and
Answers | Latest Version | 2025/2026 |
Correct & Verified
A 65-year-old male presents with new-onset fatigue and pallor. Which lab is most appropriate to
order first?
A. Liver function tests
✔✔B. Complete blood count
C. Thyroid panel
D. Hemoglobin A1c
Which of the following vaccines is recommended annually for adults over 65 years old?
✔✔A. Influenza
B. MMR
C. Hepatitis A
D. Varicella
Which of the following blood pressure readings qualifies as stage 1 hypertension according to
current guidelines?
1
,✔✔A. 134/84 mmHg
B. 126/76 mmHg
C. 142/88 mmHg
D. 120/70 mmHg
What is the most appropriate next step for a 55-year-old male with a 30-pack-year smoking
history and no symptoms?
✔✔A. Order low-dose CT scan for lung cancer screening
B. Begin antibiotics for possible pneumonia
C. Schedule a bronchoscopy
D. Order a chest x-ray annually
Which medication is most appropriate as initial therapy for a newly diagnosed type 2 diabetic
with an A1c of 7.5%?
✔✔A. Metformin
B. Glipizide
C. Insulin
D. Sitagliptin
2
,Which of the following symptoms is most consistent with benign prostatic hyperplasia (BPH)?
✔✔A. Weak urine stream and hesitancy
B. Severe flank pain and hematuria
C. High fever and dysuria
D. Nocturnal diarrhea
What is the first-line pharmacologic treatment for mild to moderate allergic rhinitis?
A. Oral decongestants
✔✔B. Intranasal corticosteroids
C. Oral corticosteroids
D. Antitussives
A 29-year-old woman presents with fatigue, cold intolerance, and weight gain. Which lab value
supports hypothyroidism?
✔✔A. Elevated TSH, low free T4
B. Low TSH, high free T4
C. Normal TSH, low free T3
3
, D. Elevated TSH, high free T3
Which of the following antibiotics is appropriate for treating uncomplicated cystitis in a healthy
young adult female?
✔✔A. Nitrofurantoin
B. Ciprofloxacin
C. Azithromycin
D. Amoxicillin-clavulanate
What is the most appropriate next step when an asymptomatic patient has a BMI of 32?
A. Start orlistat
✔✔B. Counsel on lifestyle changes and dietary modification
C. Order fasting glucose only
D. Schedule gastric bypass consultation
Which of the following is most appropriate to treat a confirmed case of streptococcal
pharyngitis?
✔✔A. Penicillin VK
4
Answers | Latest Version | 2025/2026 |
Correct & Verified
A 65-year-old male presents with new-onset fatigue and pallor. Which lab is most appropriate to
order first?
A. Liver function tests
✔✔B. Complete blood count
C. Thyroid panel
D. Hemoglobin A1c
Which of the following vaccines is recommended annually for adults over 65 years old?
✔✔A. Influenza
B. MMR
C. Hepatitis A
D. Varicella
Which of the following blood pressure readings qualifies as stage 1 hypertension according to
current guidelines?
1
,✔✔A. 134/84 mmHg
B. 126/76 mmHg
C. 142/88 mmHg
D. 120/70 mmHg
What is the most appropriate next step for a 55-year-old male with a 30-pack-year smoking
history and no symptoms?
✔✔A. Order low-dose CT scan for lung cancer screening
B. Begin antibiotics for possible pneumonia
C. Schedule a bronchoscopy
D. Order a chest x-ray annually
Which medication is most appropriate as initial therapy for a newly diagnosed type 2 diabetic
with an A1c of 7.5%?
✔✔A. Metformin
B. Glipizide
C. Insulin
D. Sitagliptin
2
,Which of the following symptoms is most consistent with benign prostatic hyperplasia (BPH)?
✔✔A. Weak urine stream and hesitancy
B. Severe flank pain and hematuria
C. High fever and dysuria
D. Nocturnal diarrhea
What is the first-line pharmacologic treatment for mild to moderate allergic rhinitis?
A. Oral decongestants
✔✔B. Intranasal corticosteroids
C. Oral corticosteroids
D. Antitussives
A 29-year-old woman presents with fatigue, cold intolerance, and weight gain. Which lab value
supports hypothyroidism?
✔✔A. Elevated TSH, low free T4
B. Low TSH, high free T4
C. Normal TSH, low free T3
3
, D. Elevated TSH, high free T3
Which of the following antibiotics is appropriate for treating uncomplicated cystitis in a healthy
young adult female?
✔✔A. Nitrofurantoin
B. Ciprofloxacin
C. Azithromycin
D. Amoxicillin-clavulanate
What is the most appropriate next step when an asymptomatic patient has a BMI of 32?
A. Start orlistat
✔✔B. Counsel on lifestyle changes and dietary modification
C. Order fasting glucose only
D. Schedule gastric bypass consultation
Which of the following is most appropriate to treat a confirmed case of streptococcal
pharyngitis?
✔✔A. Penicillin VK
4
