Cell Signaling and Communication
CELL JUNCTIONS, CELL
ADHESION MOLECULES
By StudEdu
,Cell
communication
• Cell to cell communication is important for
multicellular organisms
• Multicellular organisms can be thought of
as behaving as community
• Trillions of cells that make up an
organism need to communicate with
each other so they can coordinate their
activities.
• Just as in a family or community, a
breakdown in communication can have
detrimental effects.
• Many metabolic disorders and cancers are
a result of malfunctioning among cells
, Cell communication
• Cells communicate by sending and receiving signals.
• Signals may come from the environment, or they may come from
other cells.
• Signal can be send through:
1. Contact with another cell (cell junction/cell adhesion)
2. molecules secreted into the extracellular space by another
cell
, Molecules that adhere cells
• There are four families of integral membrane
proteins that play a role in mediating cell-cell
adhesion:
1. Selectins
2. Immunoglobulin superfamily
3. Cadherins
Selectins are a family of integral membrane
glycoproteins that recognize and bind to
oligosaccharides that project from the surfaces
of other cells.
CELL JUNCTIONS, CELL
ADHESION MOLECULES
By StudEdu
,Cell
communication
• Cell to cell communication is important for
multicellular organisms
• Multicellular organisms can be thought of
as behaving as community
• Trillions of cells that make up an
organism need to communicate with
each other so they can coordinate their
activities.
• Just as in a family or community, a
breakdown in communication can have
detrimental effects.
• Many metabolic disorders and cancers are
a result of malfunctioning among cells
, Cell communication
• Cells communicate by sending and receiving signals.
• Signals may come from the environment, or they may come from
other cells.
• Signal can be send through:
1. Contact with another cell (cell junction/cell adhesion)
2. molecules secreted into the extracellular space by another
cell
, Molecules that adhere cells
• There are four families of integral membrane
proteins that play a role in mediating cell-cell
adhesion:
1. Selectins
2. Immunoglobulin superfamily
3. Cadherins
Selectins are a family of integral membrane
glycoproteins that recognize and bind to
oligosaccharides that project from the surfaces
of other cells.
