NURS
549
/
MIDTERM
/
EXAM
/
QUESTIONS WITH CORRECT ANSWERS
/ / / /
pharmacodynamics /- /verified /answer(s)-✔✔what /the /drug /does /to /the /body
pharmacokinetics /- /verified /answer(s)-✔✔what /the /body /does /to /the /drug
pharmacogenetics /- /verified /answer(s)-
✔✔individual /variation /in /pharmacokinetics /usually /caused /by /a /single /gene
receptor-agonist /theory /- /verified /answer(s)-
✔✔pharmacologic
/agents
/are
/either
/agonists
/or
/antagonists;
/receptors /are /located /on /the /cell /membranes /and /within /the /cell /on /certain /structures
agonist /- /verified /answer(s)-
✔✔bind /to /a /receptor /and /produce /some /sort /of /biologic /response
antagonist /- /verified /answer(s)-✔✔bind /to /a /receptor /and /block /the /action /of /an /agonist
,efficacy /- /verified /answer(s)-
✔✔the /max /response /that /a /drug /can /produce; /how /well /a /drug /produces /a /response
potency /- /verified /answer(s)-✔✔the /amount /of /drug /required /to /produce /an /effect
bioavailability /- /verified /answer(s)-
✔✔the
/fraction
/of /drug /that /reaches /circulation /in /a /form /that /is /ready /to /engage /in /a /biological /response
4 /primary /mechanisms /of /drug /metabolism /- /verified /answer(s)-✔✔1. /oxidation
2. /dehydrogenation
3. /hyrolysis
4. /CYP450 /degradation
most /common /form /of /drug /metabolism /- /verified /answer(s)-✔✔CYP450 /degradation
CYP450 /Substrate /- /verified /answer(s)-✔✔the /drug /that /is /metabolize /by /the /cascade
CYP450 /inhibitor /- /verified /answer(s)-✔✔a /drug /that /inhibits /the /cascade
CYP450 /inducer /- /verified /answer(s)-✔✔a /drug /that /induces /the /cascade
first-pass /effect /- /verified /answer(s)-
✔✔when /taken /orally, /a /large /portion /of /drug /is /metabolized /during /its /first /pass /through /the
/liver /before /even /reaching /circulation
, how /many /doses /are /typically /needed /to /achieve /steady /state? /- /verified /answer(s)-✔✔5
cholesterol /- /verified /answer(s)-
✔✔the
/primary
/structural /compound /of /cell /membranes; /precursor /to /bile /salts /and /steroid /hormones
glycerophospholipids/sphingoloids /- /verified /answer(s)-
✔✔found
/at
/the
/edges /of /cell /membranes; /provide /the /hydrophobic /barrier /between /water /and /cholesterol
fatty /acids/triacylglycerol /- /verified /answer(s)-✔✔the /major /fuel
eicosanoids /- /verified /answer(s)-
✔✔prostaglandin /precursors; /regulate /numerous /body /processes
bile /salts /- /verified /answer(s)-✔✔emulsify /dietary /fats
steroid /hormones /- /verified /answer(s)-✔✔glucocorticoids, /mineralocorticoids, /sex /hormones
fat /soluble /vitamins /- /verified /answer(s)-
✔✔A,D,E,K; /integral /to /vision, /growth, /clotting, /prevention /of /oxidative /damage
HMG-CoA /Reductase /Inhibitors /- /verified /answer(s)-
✔✔statins;
/inhibit
/the
/conversion
/of
549
/
MIDTERM
/
EXAM
/
QUESTIONS WITH CORRECT ANSWERS
/ / / /
pharmacodynamics /- /verified /answer(s)-✔✔what /the /drug /does /to /the /body
pharmacokinetics /- /verified /answer(s)-✔✔what /the /body /does /to /the /drug
pharmacogenetics /- /verified /answer(s)-
✔✔individual /variation /in /pharmacokinetics /usually /caused /by /a /single /gene
receptor-agonist /theory /- /verified /answer(s)-
✔✔pharmacologic
/agents
/are
/either
/agonists
/or
/antagonists;
/receptors /are /located /on /the /cell /membranes /and /within /the /cell /on /certain /structures
agonist /- /verified /answer(s)-
✔✔bind /to /a /receptor /and /produce /some /sort /of /biologic /response
antagonist /- /verified /answer(s)-✔✔bind /to /a /receptor /and /block /the /action /of /an /agonist
,efficacy /- /verified /answer(s)-
✔✔the /max /response /that /a /drug /can /produce; /how /well /a /drug /produces /a /response
potency /- /verified /answer(s)-✔✔the /amount /of /drug /required /to /produce /an /effect
bioavailability /- /verified /answer(s)-
✔✔the
/fraction
/of /drug /that /reaches /circulation /in /a /form /that /is /ready /to /engage /in /a /biological /response
4 /primary /mechanisms /of /drug /metabolism /- /verified /answer(s)-✔✔1. /oxidation
2. /dehydrogenation
3. /hyrolysis
4. /CYP450 /degradation
most /common /form /of /drug /metabolism /- /verified /answer(s)-✔✔CYP450 /degradation
CYP450 /Substrate /- /verified /answer(s)-✔✔the /drug /that /is /metabolize /by /the /cascade
CYP450 /inhibitor /- /verified /answer(s)-✔✔a /drug /that /inhibits /the /cascade
CYP450 /inducer /- /verified /answer(s)-✔✔a /drug /that /induces /the /cascade
first-pass /effect /- /verified /answer(s)-
✔✔when /taken /orally, /a /large /portion /of /drug /is /metabolized /during /its /first /pass /through /the
/liver /before /even /reaching /circulation
, how /many /doses /are /typically /needed /to /achieve /steady /state? /- /verified /answer(s)-✔✔5
cholesterol /- /verified /answer(s)-
✔✔the
/primary
/structural /compound /of /cell /membranes; /precursor /to /bile /salts /and /steroid /hormones
glycerophospholipids/sphingoloids /- /verified /answer(s)-
✔✔found
/at
/the
/edges /of /cell /membranes; /provide /the /hydrophobic /barrier /between /water /and /cholesterol
fatty /acids/triacylglycerol /- /verified /answer(s)-✔✔the /major /fuel
eicosanoids /- /verified /answer(s)-
✔✔prostaglandin /precursors; /regulate /numerous /body /processes
bile /salts /- /verified /answer(s)-✔✔emulsify /dietary /fats
steroid /hormones /- /verified /answer(s)-✔✔glucocorticoids, /mineralocorticoids, /sex /hormones
fat /soluble /vitamins /- /verified /answer(s)-
✔✔A,D,E,K; /integral /to /vision, /growth, /clotting, /prevention /of /oxidative /damage
HMG-CoA /Reductase /Inhibitors /- /verified /answer(s)-
✔✔statins;
/inhibit
/the
/conversion
/of
