IRON EXAM QUESTIONS AND CORRECT
DETAILED ANSWERS WELL VERIFIED .GRADED
A+
What effects does hemochromatosis have? - ANSWER -excessive iron
in circulation which overwhelms transferrin-iron-binding capacity,
resulting in non-transferrin-bound iron and labile plasma iron floating in
the blood. This is very dangerous to have unbound iron floating in the
body
What are the effects of having free iron in the blood? - ANSWER -free
radical damage and can cause significant morbidity and mortality
, What is the treatment for hemochromatosis? - ANSWER -phlebotomy
(removal of 400-500mL of blood)
What kind of patients have more severe hemochromatosis? - ANSWER
-homozygous
What is an alternative treatment for hemochromatosis? - ANSWER -
Deferoxamine, which chelates iron and increases urinary iron excretion
What is hepcidin? - ANSWER -the protein that is synthesized and
secreted from the liver when it senses that iron sources are high
What is the primary action of hepcidin? - ANSWER -Hepcidin goes to
the basolateral membrane of the enterocyte and binds to ferroportin,
blocking it from being able to pump out any iron
What is a secondary action of hepcidin? - ANSWER -role in recycling
and storage
What are the effects of higher hepcidin levels, as well as lower hepcidin
levels? - ANSWER -Higher hepcidin will block the release of iron from
macrophages and liver stores. It binds ferroportin, complexes and both
are degraded. The iron will remain within the macrophages or in stores
DETAILED ANSWERS WELL VERIFIED .GRADED
A+
What effects does hemochromatosis have? - ANSWER -excessive iron
in circulation which overwhelms transferrin-iron-binding capacity,
resulting in non-transferrin-bound iron and labile plasma iron floating in
the blood. This is very dangerous to have unbound iron floating in the
body
What are the effects of having free iron in the blood? - ANSWER -free
radical damage and can cause significant morbidity and mortality
, What is the treatment for hemochromatosis? - ANSWER -phlebotomy
(removal of 400-500mL of blood)
What kind of patients have more severe hemochromatosis? - ANSWER
-homozygous
What is an alternative treatment for hemochromatosis? - ANSWER -
Deferoxamine, which chelates iron and increases urinary iron excretion
What is hepcidin? - ANSWER -the protein that is synthesized and
secreted from the liver when it senses that iron sources are high
What is the primary action of hepcidin? - ANSWER -Hepcidin goes to
the basolateral membrane of the enterocyte and binds to ferroportin,
blocking it from being able to pump out any iron
What is a secondary action of hepcidin? - ANSWER -role in recycling
and storage
What are the effects of higher hepcidin levels, as well as lower hepcidin
levels? - ANSWER -Higher hepcidin will block the release of iron from
macrophages and liver stores. It binds ferroportin, complexes and both
are degraded. The iron will remain within the macrophages or in stores
