EXAM 350 QUESTIONS AND CORRECT
DETAILED ANSWERS (VERIFIED ANSWERS) |ALREADY GRADED A+
,The pathophysiologic presentation of gout is closely linked to the metabolism of
which chemical?
a. Purine
b. Pyrimidine
c. Vitamin E
d. Amino acid - ....ANSWER...a. Purine
Exp: The pathophysiologic presentation of gout is closely linked only to purine
metabolism (or cellular metabolism of purines) and kidney function. page 1575
Which clinical manifestations are associated with fibromyalgia?
a. Hot, tender, and edematous muscle groups bilaterally
b. Fasciculations of the upper and lower extremity muscles
c. Exercise intolerance and painful muscle cramps
d. Sensitivity at tender points and profound fatigue -
....ANSWER...d. Sensitivity at tender points and profound fatigue
Exp: Widespread joint and muscle pain, fatigue, and tender points are
characteristics of fibromyalgia, a chronic musculoskeletal syndrome. Increased
sensitivity to touch (i.e. tender points) the absence of systemic or localized
inflammation, and fatigue and sleep disturbances are common. Fatigue is
profound. The remaining options include symptoms not generally associated with
fibromyalgia. page 1579-1580
,What term is used to identify the calcium crystals that are associated with
chronic gout?
a. Stones
b. Spurs
c. Tophi
d. Nodes - ....ANSWER...c. Tophi
Exp: With time, crystal deposition in subcutaneous tissues causes the formation
of small white nodules, or tophi, that are visible through the skin. Crystal
aggregates deposited in the kidneys can form urate renal stones and lead to
renal failure. None of the other options are associated with the calcium crystals
resulting from chronic gout. page 1575
Which structures are most often affected by Paget disease? (Select all that
apply.)
a. Vertebrae
b. Skull
c. Sternum
d. Metacarpals
e. Pelvis - ....ANSWER...Vertebrae, skull, sternum and pelvis.
Exp: Paget disease most often affects the axial skeleton% especially the
vertebrae, skull, sacrum, sternum, and pelvis. The metacarpals are not associated
with the axial skeleton or Paget disease. page 1558
Which muscular dystrophy syndrome develops from an X- linked recessive mode
of inheritance?
, a. Duchenne
b. Facioscapulohumeral
c. Myotonic
d. Limb girdle - ....ANSWER...a. Duchenne
Exp: A deletion of a segment of DNA or a single-gene defect on the short arm of
the X chromosome is believed to be the cause of the X-linked inherited type of
Duchenne muscular dystrophy. This statement is not true of the other options.
page 1606-1607 Table 45-7
Which protein, absent in muscle cells of Duchenne muscular dystrophy, mediates
the anchoring of skeletal muscle fibers to the basement membrane?
a. Syntrophin
b. Laminin
c. Dystrophin
d. Troponin - ....ANSWER...c. Dystrophin
Exp: Only dystrophin is present in normal muscle cells and absent in Duchenne
muscular dystrophy. Dystrophin mediates anchorage of the actin cytoskeleton of
skeletal muscle fibers to the basement membrane through a membrane
glycoprotein complex. page 1607
What pulmonary complication in children with Duchenne muscular dystrophy
contributes to their death?
a. Infection
b. Kyphoscoliosis