Lecture 7-GIP and GLP-1 questions and answers.

Lecture 7-GIP and GLP-1
glucose-dependent insulinotropic peptide - questions and answersGIP

Oral - questions and answers___ glucose gives greater insulin response than IV, IP, or
SC

reduced - questions and answersThere is a ____ incretin effect in people with Type 2
Diabetes

Food - questions and answers___ stimulates incretin secretion

7-36 - questions and answersThe bioactive form of GLP-1 is (___) amide

1-42 - questions and answersThe bioactive form of GIP is (___)

GLP-1
GIP - questions and answersDPP-4 converts ___ and ___ to their inactive metabolites

N - questions and answersDPP-4 cleaves off at the ___-terminus of each (GLP-1 and
GIP), inactivating them

2 - questions and answersDPP-4 cleaves off the first ___ amino acids of GIP and
GLP-1, deactivating them

portal
systemic - questions and answersDPP-4 is widely expressed, including on the surface
of ___ endothelial cells so a large proportion o GLP-1 and GIP never reach the ___
circulation

9-36
3-42 - questions and answersThe inactive form of GLP-1 is (___) amide and the inactive
form of GIP is (____)

GIP - questions and answersK cells release ___

duodenum - questions and answersK cells are primarily found in the ___

GLP-1 - questions and answersL cells release ___

, ileum and colon - questions and answersL cells are found distally, in the ___ and ___

peripheral - questions and answersGIP actions occur in ___ tissues

GIP and GLP-1 - questions and answersThe incretin effect is lost after ___ and ___ are
proteolyzed by DPP-4

nutrients - questions and answersGIP secretion is stimulated by ___

depolarization
GIP - questions and answersWhen K cells sense nutrients, they promote ___ of the
membrane, causing an increase of Ca2+ into the cell to release ___

directly - questions and answersThe Uptake pathway ___ takes up glucose and ions

2 and 5 - questions and answersThe Uptake pathway of glucose via the electroneutral
pathway into K cells occurs through the GLUT___ and GLUT___ transporters

1 and 3 - questions and answersThe Uptake pathway of glucose via the electrogenic
pathway into K cells occurs through SGLT___ and SGLT___

- questions and answers___ of glucose into the K cell occurs via the transporters
GLUT2 and GLUT 5 (electroneutral pathway) or SGLT1 and SGLT3 (electrogenic
pathway)

increase - questions and answersOnce glucose has entered into the K cell, this will ___
the ATP/ADP ratio, by generating more energy

Katp channel - questions and answersAn increase in ATP in the K cell inhibits the ___
channel, depolarizing the cell

does not - questions and answersThe Surface Detection pathway ___ transport things
into the cell directly

SGLT3 - questions and answersThe Surface Detection pathway of glucose in K cells,
via electrogenic path, involves the ___ transporter

Tas - questions and answersThe Surface Detection pathway of glucose in K cells, via
electroneutral path, involves the ___ receptor