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ANCC Exam Preparation – Practice Questions with Detailed Explanations (USA, 2025) – Comprehensive Review Material for Nurse Practitioners

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This document contains an extensive set of practice questions and answers tailored for the ANCC (American Nurses Credentialing Center) certification exam. It covers major clinical areas such as primary, secondary, and tertiary prevention, immunizations, ophthalmology, ENT, pharmacology, cardiology, endocrinology, pediatrics, infectious diseases, and psychiatry. Each section provides in-depth rationales and clinical decision-making tips aligned with current U.S. healthcare guidelines. This material is suitable for advanced practice nursing students and professionals preparing for board certification.

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ANCC Exam PRACTICE
Types of Prevention
 Primary Prevention: Aims to prevent the health problem from occurring in the first place. This
is often the most cost-effective form of healthcare.
o Examples:
 Car restraints
 Bicycle helmets
 Immunizations
 Ensuring adequate illumination at home to prevent falls
 Secondary Prevention: Focuses on detecting disease in its early, asymptomatic stages.
o Involves screenings to identify asymptomatic disease through testing.
o Example: A highly abnormal mammogram requires further investigation and is not a
definitive diagnosis.
 Tertiary Prevention: Centers on managing established disease to minimize negative outcomes.
It can be seen as a consequence when primary prevention has not been fully effective.
o Examples:
 Medications
 Lifestyle management
 Rehabilitation (rehab)
 Physical Therapy (PT)
 Occupational Therapy (OT)



Vaccinations: Key Considerations
Influenza Vaccine
 Contraindications: Generally not recommended for infants younger than 6 months.
o Specifically, a 4-month-old born at 32 weeks gestation should not receive the flu vaccine.
 Recommendations:
o 6 months and older: Can receive the influenza vaccine.
o Pregnancy/Lactation: Safe to administer during both.
o Children: Require two doses administered 4 weeks apart.


MMR Vaccine (Measles, Mumps, Rubella)
 Contraindications:




, .

o Pregnancy: Absolutely contraindicated (along with varicella, zoster, smallpox, flu mist,
rotavirus vaccines).
o Lactation is safe.
 Important Notes:
o It is a live but weakened vaccine.
o A second dose is recommended for individuals born after 1957.
o Infants aged 6-11 months traveling outside the US should receive a dose.
o A mild, innocent flat pink rash may occur post-vaccination.
o Dosage Schedule: Two doses are typically given:
 First dose: 12-15 months
 Second dose: 4-6 years


Tetanus Vaccine
 Transmission: Can be contracted from soil. The depth of the wound is a significant factor.
 Pregnancy: Pregnant individuals should receive a Tdap vaccine during their third trimester to
provide passive immunity to the unborn child against pertussis.
 Pertussis Prevention: Family members should be up-to-date on their pertussis vaccination to
protect newborns (pertussis can lead to lockjaw).
 Vaccine Types and Schedules:
o Tdap: One dose between 11-64 years, followed by a booster every 10 years.
o DTaP: A series of five doses typically given in childhood.
 Pertussis (Whooping Cough):
o Symptoms: Uncontrollable cough, vomiting, fatigue.
o Diagnosis: Nasopharyngeal culture and PCR testing.
o Treatment: Azithromycin.



Screening Guidelines
Pap Smear
 No Routine Screening: Recommended prior to age 21 or in elderly individuals who meet
specific low-risk criteria.

Medication Considerations
Benadryl (Diphenhydramine)
 Older Adults: Use with caution due to anticholinergic effects.
o Can cross the blood-brain barrier (BBB), leading to sedation.




, o May cause urinary retention, which is particularly problematic for individuals with
Benign Prostatic Hyperplasia (BPH).

Viral Infections
Herpes Zoster (Shingles)
 A reactivation of the varicella-zoster virus (chickenpox).
 Zoster Vaccine: A stronger vaccine specifically for shingles.
 Post-Herpetic Neuralgia: Persistent nerve pain that can last for more than one month after the
shingles rash resolves.
 Herpes Keratitis: Damage to the corneal epithelium caused by the herpes virus (commonly
shingles).
o Symptoms: Acute onset of eye pain, photophobia, and blurred vision in the affected eye.



Ophthalmological Conditions
Primary Open Angle Glaucoma
 Characterized by peripheral vision loss, elevated intraocular pressure, and deep-cupping of
the optic disc.
 Treatment: Medications such as:
o Beta-adrenergic antagonists (Timolol)
o Alpha agonists
o Prostaglandin analogues
 Screening Test: Tonometry measures intraocular pressure.

Normative Aging (Eyesight)
 A common physiological change is the need for increased illumination for tasks.

Macular Degeneration
 Leads to central vision loss.
 A major cause of new-onset blindness in the elderly.
 More prevalent in females.
 Screening Test: Amsler grid test.






, .


Inner Ear Disorders
Meniere's Disease vs. Meniere's Syndrome
 Symptoms: Dizziness, tinnitus, nystagmus, vertigo.
 Risk Factors: Ototoxic drugs.
 Treatment:
o Benzodiazepines: For rest and acute management.
o Corticosteroids: For anti-inflammatory effects.
 Distinction:
o Meniere's disease: Idiopathic (unknown cause).
o Meniere's syndrome: Secondary to a known underlying condition.



Oral Health
Oral Cancer
 Typically presents as an ulcerated lesion with indurated margins.
 The most common type is Squamous Cell Carcinoma (SCC).
 Risk Factors: HPV 16.
 Screening: Often detected during dental visits.

Pharmacology: Allergic Reactions
Beta-Lactam Antibiotics
 Include penicillins, cephalosporins, and carbapenems.
 Rashes are a common allergic reaction, particularly associated with Epstein-Barr virus (EBV)
infection when taking certain beta-lactams.

Ear Infections
Otitis Externa (Swimmer's Ear)
 Commonly caused by fungus (Candida or Aspergillus) or Pseudomonas aeruginosa.
 Hallmark Sign: Pain on palpating the tragus (the small flap of cartilage in front of the ear
canal).
 Treatment: Fluoroquinolone ear drops.
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