Blood Bank Exam Simulator Questions
CERTIFICATION GUIDE
FOR 2025/2026 TESTS|MOST COMMON
QUESTIONS WITH CORRECTLY VERIFIED ANSWERS
(LATEST QUIZZES) |ALREADY A+
GRADED|GUARANTEED PASS
Which of the following is considered an indication for Rh immune globulin (RhIG) administration
in postpartum women?
A) long term protection
B) antibody blocking
C) passive protection
D) active immunity - C) passive protection
The lectin Dolichus biflorus agglutinates which types of cells?
A) B cells
B) A1B cells
C) A2 cells
D) both A1B and A2 cells - B) A1B cells
When performing an antibody panel, which one of the following antigens will be destroyed by
enzyme treatment?
A) Fya
,B) Jka
C) E
D) Lua - A) Fya
Which of the following is the proper storage temperature for fresh frozen plasma (FFP)?
A) 37 degrees C
B) 4 degrees C
C) -20 degrees C
D) -10 degrees C - C) -20 degrees C
Which of the following blood components will provide the best source of fibrinogen for a
patient with hypofibrinogenemia?
A) whole blood
B) fresh frozen plasma
C) platelets
D) cryoprecipitate - D) cryoprecipitate
Which characteristic best describes IgG antibodies produced against red blood cells?
A) are naturally occurring
B) cannot be identified using the AHG test
C) react best at room temperature
D) reacts best at 37 C - D) reacts best at 37C
Which of the following immunoglobulins are capable of fixing complement by the classical
pathway?
A) IgG and IgA
,B) IgM and IgA
C) IgG and IgM
D) IgG and IgD - C) IgG and IgM
Which of the following choices best describes the primary function of antibodies?
A) protection of B-lymphocytes
B) binds with antigen
C) fixes complement
D) stimulates the immune response - B) binds with antigen
It's a busy Friday evening in the blood bank and you have been receiving a steady stream of type
and screen specimens from the emergency room. Several of them have positive antibodies
screens which require further workup. One fo these patients is a 46 y/o male whose
hemoglobin has dropped from 8.4 g/dl to 4.6 g/dl in the previous 8 hours (normal HgB for this
patient demographic would be ~14 g/dl). Your work up reveals a group O patient with the
following antibodies: anti-K, anti-Fya. The prevalence of K negative in your donor population is
91% while the prevalence of Fya negative donors is 37%. Two units of cross-matched RBCs are
requested by the physician. How many units of group O RBC units should you phenotype in
order to fulfill the request for two cross-matched units?
A) 2 units of type O RBC units
B) 3 units of type O RBC units
C) 6 units of type O RBC units
D) 12 units of type O RBC units - C) 6 units of type O RBC units
A ficin (enzyme) treated panel can be a useful tool for determining the identify of an antibody.
On a ficin-treated panel, reactions with which system would be enhanced?
A) Rh
B) Duffy
C) MNS
, D) Kell - A) Rh
Which of the following might cause a false positive indirected antiglobulin test (IAT)?
A) failure to adequately wash cells
B) delay in the addition of antiglobulin reagents
C) over-centrifugation
D) high concentration of IgG paraprotein in a patient's serum - C) over-centrifugation
ABORh
Anti-A: 4+
Anti-B: 4+
Anti-AB: 4+
A1 Cells: 1+
B Cells: 0
ABO Group Interpretation: ?
A) Group AB
B) Group O
C) Group B
D) Inconclusive, could be A2B with anti-A1 in the serum; further testing is necessary - D)
Inconclusive, could be A2B with anti-A1 in the serum; further testing is necessary
Which of the following situations warrants postpartum administration of Rh immune globulin
(RhIg)?
A) Mother: D postive Cord: D Negative
CERTIFICATION GUIDE
FOR 2025/2026 TESTS|MOST COMMON
QUESTIONS WITH CORRECTLY VERIFIED ANSWERS
(LATEST QUIZZES) |ALREADY A+
GRADED|GUARANTEED PASS
Which of the following is considered an indication for Rh immune globulin (RhIG) administration
in postpartum women?
A) long term protection
B) antibody blocking
C) passive protection
D) active immunity - C) passive protection
The lectin Dolichus biflorus agglutinates which types of cells?
A) B cells
B) A1B cells
C) A2 cells
D) both A1B and A2 cells - B) A1B cells
When performing an antibody panel, which one of the following antigens will be destroyed by
enzyme treatment?
A) Fya
,B) Jka
C) E
D) Lua - A) Fya
Which of the following is the proper storage temperature for fresh frozen plasma (FFP)?
A) 37 degrees C
B) 4 degrees C
C) -20 degrees C
D) -10 degrees C - C) -20 degrees C
Which of the following blood components will provide the best source of fibrinogen for a
patient with hypofibrinogenemia?
A) whole blood
B) fresh frozen plasma
C) platelets
D) cryoprecipitate - D) cryoprecipitate
Which characteristic best describes IgG antibodies produced against red blood cells?
A) are naturally occurring
B) cannot be identified using the AHG test
C) react best at room temperature
D) reacts best at 37 C - D) reacts best at 37C
Which of the following immunoglobulins are capable of fixing complement by the classical
pathway?
A) IgG and IgA
,B) IgM and IgA
C) IgG and IgM
D) IgG and IgD - C) IgG and IgM
Which of the following choices best describes the primary function of antibodies?
A) protection of B-lymphocytes
B) binds with antigen
C) fixes complement
D) stimulates the immune response - B) binds with antigen
It's a busy Friday evening in the blood bank and you have been receiving a steady stream of type
and screen specimens from the emergency room. Several of them have positive antibodies
screens which require further workup. One fo these patients is a 46 y/o male whose
hemoglobin has dropped from 8.4 g/dl to 4.6 g/dl in the previous 8 hours (normal HgB for this
patient demographic would be ~14 g/dl). Your work up reveals a group O patient with the
following antibodies: anti-K, anti-Fya. The prevalence of K negative in your donor population is
91% while the prevalence of Fya negative donors is 37%. Two units of cross-matched RBCs are
requested by the physician. How many units of group O RBC units should you phenotype in
order to fulfill the request for two cross-matched units?
A) 2 units of type O RBC units
B) 3 units of type O RBC units
C) 6 units of type O RBC units
D) 12 units of type O RBC units - C) 6 units of type O RBC units
A ficin (enzyme) treated panel can be a useful tool for determining the identify of an antibody.
On a ficin-treated panel, reactions with which system would be enhanced?
A) Rh
B) Duffy
C) MNS
, D) Kell - A) Rh
Which of the following might cause a false positive indirected antiglobulin test (IAT)?
A) failure to adequately wash cells
B) delay in the addition of antiglobulin reagents
C) over-centrifugation
D) high concentration of IgG paraprotein in a patient's serum - C) over-centrifugation
ABORh
Anti-A: 4+
Anti-B: 4+
Anti-AB: 4+
A1 Cells: 1+
B Cells: 0
ABO Group Interpretation: ?
A) Group AB
B) Group O
C) Group B
D) Inconclusive, could be A2B with anti-A1 in the serum; further testing is necessary - D)
Inconclusive, could be A2B with anti-A1 in the serum; further testing is necessary
Which of the following situations warrants postpartum administration of Rh immune globulin
(RhIg)?
A) Mother: D postive Cord: D Negative
