EVOLVE 1 CLINICAL DRUG THERAPY QUESTIONS AND RATIONED ANSWERS FOR NURSING

EVOLVE 1 CLINICAL DRUG THERAPY
QUESTIONS AND RATIONED
ANSWERS FOR NURSING PRACTICES
QUESTIONS WITH CORRECT
ANSWERS 2025/2026
WhichAstatementsAaboutAmedicationAshouldAtheAnurseAidentifyAasAtrue?ASelectAallAthatAapply.A
-AcorrectAanswersAllAdrugsAhaveAtheApotentialAtoAproduceAundesiredAeffects.

DrugAtherapyAoftenAcanAbeAenhancedAbyAnonpharmacologicAmeasures.
A



TheAmoreAdrugsAaApatientAtakes,AtheAmoreAlikelyAaAdrugAinteractionAwillAoccur.
A



PatientAadherenceAisAessentialAinAachievingAtheAtherapeuticAobjectiveAofAmedications.
A



TheAtreatmentAofAanAoverdoseAofAwhichAdrugAinvolvesAgivingAanAagentAthatAelevatesAurinaryAp
H?A-AcorrectAanswersAspirin

AspirinAisAanAacidicAdrug,AandAacidsAtendAtoAionizeAinAbasicAmedia.AElevationAofAurinaryApHAcau
sesAmoreAofAtheAaspirinAmoleculesAinAurineAtoAbecomeAionizedAcausingAlessAofAtheAdrugAtoAbeA
passivelyAreabsorbed.

WhatAareAtheAthreeAmostAimportantAcharacteristicsAthatAanyAdrugAcanAhave?ASelectAallAthatAap
ply.A-AcorrectAanswersEffectiveness,Asafety,Aselectivity

TheAnurseAmanagerAisAteachingAaAgroupAofAnursesAaboutAmedicationAerrorAreportingAprograms
AinAtheAUnitedAStates.AWhichAresponseAindicatesAtheAteachingAwasAeffective?A-


AcorrectAanswers"HospitalApharmaciesAmustAhaveAanAadverseAdrugAeventAmonitoringAprogram


."

EveryAhospitalApharmacyAshouldAhaveAanAadverse-drug-
eventAmonitoringAprogramAinAwhichAtheAerrorsAthatAcausedAtheAdrugAinteractionsAandAfood-
drugAinteractionsAareAreported.AItAhelpsAtoAprescribeAmedicationsAsafelyAwithAreducedAsideAeff
ects.ATheAnurseAcanAreportAadverseAeffectsAcausedAbyAmedicationAerrorsAfoundAinAinpatientsAa
ndAoutpatients.AAllAmedicationAerrors,AregardlessAofAseverity,AmustAbeAenteredAinAtheAU.S.APha
rmacopeiaAdatabase.

AAdrugAadministeredAbyAwhichArouteArequiresAtheAmostAimmediateAevaluationAofAtherapeuticA
effect?A-AcorrectAanswersIntravenous

IntravenousAdrugsAareAabsorbedAmoreAquicklyAthanAoral,Asubcutaneous,AorAtopicalAdrugs.ATheA
bioavailabilityAofAintravenousAdrugsAisA100%,AandAtheseAdrugsArequireAtheAmostAimmediateAev
aluationAofAtherapeuticAeffect.

,TheAnurseAadministersAtheAdrugAdobutamineAtoAincreaseAtheAcontractileAforceAofAtheAheart.AT
hroughAwhatAprimaryAactionAdoesAthisAdrugAhaveAitsAtherapeuticAeffect?A-
AcorrectAanswersNorepinephrineA(NE)Aagonist



DobutamineAisAaAdrugAthatAmimicsAtheAactionAofAtheAneurotransmitterANEAandAactsAasAanAagon
ist.AIntrinsicAactivityArefersAtoAaAdrug'sAabilityAtoAactivateAaAreceptorAuponAbinding.AAffinityArefe
rsAtoAtheAstrengthAofAtheAattractionAbetweenAaAdrugAandAitsAreceptor.

TheAnurseAadministersAmeperidineAandApromethazine.AWhichAresponseAdoesAtheAnurseAantici
pateAbecauseAofAtheirApotentiatingAeffect?A-AcorrectAanswersIncreasedApainArelief

MeperidineAandApromethazineAhaveAaApotentiatingAeffect,AmeaningAthatAoneAdrugA(prometha
zine)AintensifiesAtheAeffectAofAtheAotherA(meperidine).AThisAmeansAthatAtheApatientAwillAhaveAa
nAincreaseAinApainArelief.ADecreasedAitchingAisAaAtherapeuticAeffectAofApromethazineAbutAisAnotA
theAresultAofAtheApotentiatingAeffectAofAtheAtwoAdrugsAusedAtogether.ABecauseAbothAmeperidin
eAandApromethazineAcanAcauseAdrowsiness,AincreasedAalertnessAisAnotAanAexpectedAeffect.

TheAnurseAisAcaringAforAaApatientAwhoAisAreceivingAintravenousA(IV)Agentamicin.ATheAhealthcare
AproviderArequestsAtheApeakAandAtroughAlevelsAofAtheAdrugAforAtheApatient.AWhenAshouldAtheA


nurseAarrangeAforAtheAbloodAsampleAtoAbeAdrawnAtoAobtainAtheAtroughAlevelAofAtheAdrug?A-
AcorrectAanswersJustAbeforeAtheAnextAdoseAisAadministered



TroughAlevelArevealsAtheArateAatAwhichAtheAdrugAisAeliminatedAfromAtheAbody.AThereforeAtheAbl
oodAsampleAmustAbeAdrawnAjustAbeforeAtheAnextAdoseAisAadministered.AAtAthisAtime,AtheAconc
entrationAofAtheAdrugAinAtheAplasmaAisAatAitsAlowest.ATheAbloodAsampleAforAtheApeakAlevelAmus
tAbeAdrawnAatAtheAproposedApeakAtime.APeakAtimeAforAoralAdrugsAmayArangeAfromA1AtoA3Ahours
.APeakAtimeAforAIVAdrugsAmayAstartAasAearlyAasA10AminutesAafterAadministration.

TheAnurseAisAconcernedAwithAminimizingAadverseAdrug-
drugAinteractionsAforAtheApatient.AWhichAdrugAcharacteristicAcouldAresultAinAtheAmostAseriousA
consequenceAfromAaAdrug-drugAinteraction?A-AcorrectAanswersNarrowAtherapeuticArange

InteractionsAareAespeciallyAimportantAwithAdrugsAthatAhaveAaAnarrowAtherapeuticArangeAbecau
seAanAinteractionAthatAproducesAaAmodestAincreaseAinAdrugAlevelsAcanAcauseAtoxicity,AandAanAin
teractionAthatAproducesAaAmodestAdecreaseAinAdrugAlevelsAcanAcauseAtherapeuticAfailure.

AApatientAisAgivenAaAdrugAthatAhasAaAhalf-
lifeAofA8Ahours.ATheApeakAlevelAofAthisAdrugAisA100Amg/L.AWhatAisAtheAconcentrationAofAtheAdru
gAafterAtwoAhalf-lives?ARecordAyourAanswerAusingAaAwholeAnumber.A-AcorrectAanswers25mg

WhatAinstructionsAwillAtheAnurseAgiveAaApatientAinApainAtoAreduceAfluctuationsAinAanalgesicAdru
gAlevels?A-
AcorrectAanswers"TakeApainAmedicationAaroundAtheAclockAatAspecifiedAintervalsAandAdoses."

, OneAtechniqueAtoAreduceAdrugAlevelAfluctuationsAisAtoAtakeAaAspecifiedAdoseAatAregularAinterval
s.AAApatientAwhoAwaitsAforAtheApainAtoApeakAwillAhaveAtoAwaitAlongerAforAtheApainAmedicineAtoA
reachAaAplateauAlevelAofApainAcontrol.

TheAnurseAteachesAaApatientAwithAdiabetesAtoAeatAfast-
actingAcarbohydratesAifAsignsAandAsymptomsAofAhypoglycemiaAdevelop.AThisAisAanAexampleAofA
whatAgoal?A-AcorrectAanswersMinimizingAadverseAeffects

HypoglycemiaAcanAbeAanAadverseAeffectAofAsomeAdiabeticAdrugs.AKnowledgeAofAwaysAtoAcount
eractAhypoglycemiaAwillAenableAtheApatientAtoAminimizeAthisAadverseAeffect.

WhichAlegislationAsetArulesAforAtheAmanufactureAandAdistributionAofAdrugsAconsideredAtoAhave
AtheApotentialAforAabuse?A-AcorrectAanswersControlledASubstancesAActAofA1970



TheAControlledASubstancesAActAofA1970AsetArulesAcoveringAdrugsAofAabuseAandAdefinedAcatego
riesAofAcontrolledAsubstances.ATheAFood,ADrug,AandACosmeticAAct,ApassedAinA1938,AwasAtheAfir
stAlegislationAtoAaddressAdrugAsafety.

AApatientAisAprescribedAaAdrugAthatAisAalmostAcompletelyAinactivatedAonAfirst-
passAmetabolism.AWhichAroutesAofAadministrationAcanAavoidAtheAfirst-
passAeffect?ASelectAallAthatAapply.A-AcorrectAanswersSublingual

Intravenous
A



Intramuscular
A



DrugsAadministeredAthroughAtheAenteralArouteAareAabsorbedAviaAtheAgastricAandAintestinalAmu
cosaAandAundergoAfirst-
passAmetabolismAinAtheAliver.ARectallyAadministeredAdrugsAmayAorAmayAnotAundergoAfirst-
passAmetabolism.AThroughAtheAsublingual,Aintravenous,AandAintramuscularAroutes,AtheAdrugAb
ypassesAtheAfirst-passAmetabolism,AandAbioavailabilityAisAhigh.

AApatientAhasAtakenAanAenteric-
coatedAmedication.AHowAwouldAthisAcoatingAaffectAdrugAabsorption?A-
AcorrectAanswersItAwillAtakeAlongerAtoAbeAabsorbed.



EntericAcoatingAisAdesignedAtoAprotectAaAdrugAfromAdissolutionAuntilAitAcanAbeAabsorbedAinAtheA
intestines.AThusAitAwillAtakeAlongerAtoAbeAabsorbed,AbecauseAabsorptionAdoesAnotAoccurAinAtheA
stomach,AandAgastric-
emptyingAtimeAvaries.ATheAmedicationAwillAbeAabsorbed,AandAtheAtimeAitAtakesAtoAbeAabsorbed
AwillAbeAslowed,AnotAincreased.AEntericAcoatedAmedicationsAdoAnotApreventAtheAfirst-


passAeffectAbyAtheAliver.

TheAnurseAisAexplainingAtoAaApatientAanAinvestigationalAnewAdrugAstudyAforAaAformAofAcancer.AT
heApatientAasksAtheAnurse,A"WillAthisAdrugAstopAmyAcancerAfromAspreading?"AWhatAwouldAbeAt
heAnurse'sAbestAresponse?A-
AcorrectAanswers"WeAareAperformingAaAtrialAtoAunderstandAitsAeffects."