DDI EXAM 1 QUESTIONS WITH 100%
SOLVED ANSWERS!!
1 of
61
Definition
-Dose
-Duration
-Dosing Times
-Sequence
-Route
-Dosage Form
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, Drug Factors Influencing DI Drug Interaction Literature:
Outcomes Potential Pitfalls
Patient Factors Influencing DI Drug Interactions as a Function of
Outcomes Medication Exposure
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2 of 61
Term
What are the two types of interaction outcomes?
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-Renal failure
-Diabetes -Codeine alone: morphine
-CHF concentration = 5 ng/mL, pain
-Age > 60 threshold = 35 mA
-Other hyperkalemic drugs -Codeine + quinidine: mophine and
(NSAIDs, etc) pain threshold essentially 0
-Dose of spiro (50 mg/day or more)
-Additive/Synergistic: -GF juice increases lovastatin ~15
exaggeration of fold
expected -GF juice increases lovastatin acid
pharmacological ~6 fold
effects
*AUC
-Antagonistic/silent:
attenuation or loss of
Cmax is slightly less elevated
pharmacologic potency
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, 3 of 61
Definition
Mean increase in protime: 40%
High amount of variability
No bleeding occurred
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Sorbitol and PEG Fluconazole and Warfarin
Lamivudine and Sorbitol Diphenhydramine and Metoprolol
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4 of 61
Definition
-Anti-diarrheal (Lomotil, Immodium)
-Opioid analgesics
-Anticholinergics for urinary incontinence (ie. oxybutynin),
Parkinson's (ie. benztropine, trihexylphenidyl), and motion sickness
(scopolamine)
-Meds with strong anticholinergic side effects (ie. diphenhydramine
and TCAs)
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, Drug Interaction Literature: Theophylline - Allopurinol
Potential Pitfalls Interaction
Drugs which decrease GI Drugs which Stimulate GI Motility
motility (Prokinetic agents)
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5 of 61
Definition
2C19 (mod) and 3A4 (weak)
1A2 (strong)
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Quinidine inhibits Diphenhydramine and Metoprolol
Fluvoxamine inhibits Fluconazole and Warfarin
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SOLVED ANSWERS!!
1 of
61
Definition
-Dose
-Duration
-Dosing Times
-Sequence
-Route
-Dosage Form
Give this one a try later!
, Drug Factors Influencing DI Drug Interaction Literature:
Outcomes Potential Pitfalls
Patient Factors Influencing DI Drug Interactions as a Function of
Outcomes Medication Exposure
Don't know?
2 of 61
Term
What are the two types of interaction outcomes?
Give this one a try later!
-Renal failure
-Diabetes -Codeine alone: morphine
-CHF concentration = 5 ng/mL, pain
-Age > 60 threshold = 35 mA
-Other hyperkalemic drugs -Codeine + quinidine: mophine and
(NSAIDs, etc) pain threshold essentially 0
-Dose of spiro (50 mg/day or more)
-Additive/Synergistic: -GF juice increases lovastatin ~15
exaggeration of fold
expected -GF juice increases lovastatin acid
pharmacological ~6 fold
effects
*AUC
-Antagonistic/silent:
attenuation or loss of
Cmax is slightly less elevated
pharmacologic potency
Don't know?
, 3 of 61
Definition
Mean increase in protime: 40%
High amount of variability
No bleeding occurred
Give this one a try later!
Sorbitol and PEG Fluconazole and Warfarin
Lamivudine and Sorbitol Diphenhydramine and Metoprolol
Don't know?
4 of 61
Definition
-Anti-diarrheal (Lomotil, Immodium)
-Opioid analgesics
-Anticholinergics for urinary incontinence (ie. oxybutynin),
Parkinson's (ie. benztropine, trihexylphenidyl), and motion sickness
(scopolamine)
-Meds with strong anticholinergic side effects (ie. diphenhydramine
and TCAs)
Give this one a try later!
, Drug Interaction Literature: Theophylline - Allopurinol
Potential Pitfalls Interaction
Drugs which decrease GI Drugs which Stimulate GI Motility
motility (Prokinetic agents)
Don't know?
5 of 61
Definition
2C19 (mod) and 3A4 (weak)
1A2 (strong)
Give this one a try later!
Quinidine inhibits Diphenhydramine and Metoprolol
Fluvoxamine inhibits Fluconazole and Warfarin
Don't know?
