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Lecture notes

Chemical Modification and Effect of pH Notes

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PDF containing notes from the Chemical Modification lecture for Pharmacology

Institution
University Of Portsmouth (UoP)
Module
Molecules to Medicine (M33311)

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Chemical Modification and the
Effect of pH
Created @November 3, 2024 6:03 PM

Class Molecules to Medicine

H0- Hydrophilic Groups
Carboxylic groups are polar
Aromatic groups are non polar
Hydroxyl groups are polar


Antilog- 10 to the power of pH

Manipulating the Solubility of a Drug

Use of co-solvents (Selecting the right solvent)

Salt formation

Adding solubilising groups to the structure

Using effects of pH

Using dosage forms



Incorporating Water Solubilising Groups

Types of group added

If reaction is reversible or irreversible

Introducing chemical routes




Chemical Modification and the Effect of pH 1
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