Biochemistry
Lecture 6
Compiled By Simon Mwangi
Edition: 2024/25
, Science | Biochemistry I of VI pages
1. your patient shows retarded growth, severe anemia and high levels of orotic acid in their urine (orotic
high orotate (one of the products/steps of pyrimidine production)
means either
oroate
-orotate phosphoribosyl transferase
=orotidylate
or
orotidylate
-orotidylate decarboxylase
UMP( uridylate)
is NOT working
Treatment: feed them pyrimidine (uridine triacetate UTP)
if body has pyrimidines then it doesnt need to make pyrimidine therefore the step/products will not be
end products feedback inhibit production of pyrimidines
2. canine with lymphomais 5-flurouracil good option?if not what is a good option?
5-FU is toxic for dogs-gastro(hypersalivation, vomiting), CNS (ataxia, seuzures) and bone marrow
Treatment: Use aminopterin (methotrexate)
-inhibits dihydrofolate reductase (dihydrofolate to tetrahydrofolate which turns into
3. called to zoo for animal with uric acid in urine and in painWhich animal?Treatment?
primate- uric acid is end product of purine degradation
treatment: ALLOPURINOLcompetitive inhibitor for xanthine oxidase (enzyme used in purine deg)-
stops hypoxanthine from changing into xanthine
stops xanthine from turning into uric acid
4. dalmatian with blood in urine
dalmatians have defect in liver and can not take up uric acid into liver to be converted into allantoin, therefore
gout can be treated will ALLOPURINOL
blocks Xanthine oxidaseuric acid is form breakdown of purines
5. treatment for leshmaniasis?
parasite that feeds on purine from host. if you use ALLOPURINOL to reduce the amount of purines the host
6. what sugar does RNA use
ribose
7. what sugar does DNA use
deoxyribose
8. pyrimidine
1 ringuracilcytosinethymine
9. purine
2 ringsadenineguanine
Pure As Gold
Biochemistry 2024/25 Edition
Lecture 6
Compiled By Simon Mwangi
Edition: 2024/25
, Science | Biochemistry I of VI pages
1. your patient shows retarded growth, severe anemia and high levels of orotic acid in their urine (orotic
high orotate (one of the products/steps of pyrimidine production)
means either
oroate
-orotate phosphoribosyl transferase
=orotidylate
or
orotidylate
-orotidylate decarboxylase
UMP( uridylate)
is NOT working
Treatment: feed them pyrimidine (uridine triacetate UTP)
if body has pyrimidines then it doesnt need to make pyrimidine therefore the step/products will not be
end products feedback inhibit production of pyrimidines
2. canine with lymphomais 5-flurouracil good option?if not what is a good option?
5-FU is toxic for dogs-gastro(hypersalivation, vomiting), CNS (ataxia, seuzures) and bone marrow
Treatment: Use aminopterin (methotrexate)
-inhibits dihydrofolate reductase (dihydrofolate to tetrahydrofolate which turns into
3. called to zoo for animal with uric acid in urine and in painWhich animal?Treatment?
primate- uric acid is end product of purine degradation
treatment: ALLOPURINOLcompetitive inhibitor for xanthine oxidase (enzyme used in purine deg)-
stops hypoxanthine from changing into xanthine
stops xanthine from turning into uric acid
4. dalmatian with blood in urine
dalmatians have defect in liver and can not take up uric acid into liver to be converted into allantoin, therefore
gout can be treated will ALLOPURINOL
blocks Xanthine oxidaseuric acid is form breakdown of purines
5. treatment for leshmaniasis?
parasite that feeds on purine from host. if you use ALLOPURINOL to reduce the amount of purines the host
6. what sugar does RNA use
ribose
7. what sugar does DNA use
deoxyribose
8. pyrimidine
1 ringuracilcytosinethymine
9. purine
2 ringsadenineguanine
Pure As Gold
Biochemistry 2024/25 Edition
