Practice questions Oncogenesis
Questions:
1. Describe the two main types of genes whose mutations are associated with cancer
development.
2. What protein is often associated with a "guardian of the genome" role and explains it’s
significance.
3. What are the six hallmarks of cancer discussed in the course?
4. How does a gain-of-function mutation in an oncogene contribute to cancer?
5. Define proto-oncogene.
6. Explain the Knudson two-hit model.
7. What model is used to explain cancer progression through genetic changes?
8. What role does the RAS protein play in cancer signaling?
9. How does the Wnt signaling pathway relate to colorectal cancer?
10. How does telomerase contribute to the 'immortality' of cancer cells?
11. What impact does aneuploidy have on cancer cells?
12. What is the purpose of massively parallel sequencing in cancer research?
13. Define chromosomal instability (CIN) and its role in cancer.
14. What is the function of receptor tyrosine kinases in cancer?
15. Why is the Rous Sarcoma Virus significant in cancer research?
16. How does the drug Nutlin-3 target p53?
17. What is a key feature of non-coding RNAs in cancer?
18. How does the APC gene mutation relate to colorectal cancer?
19. Explain how massively parallel sequencing aids in cancer genomics research.
20. How does the protein eIF4E contribute to cancer development?
21. What is the 'elephant paradox' in cancer research?
22. Explain the relationship between telomeres and cancer.
23. Explain the role of single-cell sequencing in understanding tumor heterogeneity.
24. What are CAFs and their role in cancer progression?
25. Describe the impact of MYC amplification in cancer.
26. Why are organoids valuable in personalized cancer treatment?
27. What is the function of cohesin in cell division?
28. How is TGF-β signaling implicated in cancer?
29. What effect does CRISPR-Cas9 have in cancer research?
30. What function does the Wnt signaling pathway serve in stem cells and cancer?
Questions:
1. Describe the two main types of genes whose mutations are associated with cancer
development.
2. What protein is often associated with a "guardian of the genome" role and explains it’s
significance.
3. What are the six hallmarks of cancer discussed in the course?
4. How does a gain-of-function mutation in an oncogene contribute to cancer?
5. Define proto-oncogene.
6. Explain the Knudson two-hit model.
7. What model is used to explain cancer progression through genetic changes?
8. What role does the RAS protein play in cancer signaling?
9. How does the Wnt signaling pathway relate to colorectal cancer?
10. How does telomerase contribute to the 'immortality' of cancer cells?
11. What impact does aneuploidy have on cancer cells?
12. What is the purpose of massively parallel sequencing in cancer research?
13. Define chromosomal instability (CIN) and its role in cancer.
14. What is the function of receptor tyrosine kinases in cancer?
15. Why is the Rous Sarcoma Virus significant in cancer research?
16. How does the drug Nutlin-3 target p53?
17. What is a key feature of non-coding RNAs in cancer?
18. How does the APC gene mutation relate to colorectal cancer?
19. Explain how massively parallel sequencing aids in cancer genomics research.
20. How does the protein eIF4E contribute to cancer development?
21. What is the 'elephant paradox' in cancer research?
22. Explain the relationship between telomeres and cancer.
23. Explain the role of single-cell sequencing in understanding tumor heterogeneity.
24. What are CAFs and their role in cancer progression?
25. Describe the impact of MYC amplification in cancer.
26. Why are organoids valuable in personalized cancer treatment?
27. What is the function of cohesin in cell division?
28. How is TGF-β signaling implicated in cancer?
29. What effect does CRISPR-Cas9 have in cancer research?
30. What function does the Wnt signaling pathway serve in stem cells and cancer?
