PATHOLOGY USMLE STEP 1 STUDY KIT
WITH COMPLETE QUESTIONS AND
CORRECT ANSWERS
Anticentromere antibodies Correct Answer Scleroderma
(CREST)
Antidesmoglein (epithelial) antibodies Correct Answer
Pemphigus vulgaris (blistering)
Anti-glomerular basement membrane antibodies Correct Answer
Goodpasture's syndrome (glomerulonehpritis and hemoptysis)
Antihistone antibodies Correct Answer Drug-induced SLE
(hydralazine, isoniazid, phenytoin, procainamide)
Anti-IgG antibodies Correct Answer Rheumatoid arthritis
(systemic inflammation, joint pannus, boutonniere deformity)
Antimitochondrial antibodies (AMAs) Correct Answer Primary
biliary cirrhosis (female, cholestasis, portal hypertension)
Antineutrophil cytoplasmic antibodies (ANCAs) Correct Answer
Vasculitis (c-ANCA: Wegener's; p-ANCA: microscopic
polyangiitis, Churg-Strauss syndrome)
Antinuclear antibodies (ANAs: anti-Smith and anti-dsDNA)
Correct Answer SLE (type III hypersensitivity)
Antiplatelet antibodies Correct Answer Idiopathic
thrombocytopenic purpura (ITP)
Anti-topoisomerase antibodies Correct Answer Diffuse systemic
scleroderma
,Anti-transglutamniase/anti-gliadin/anti-endomysial antibodies
Correct Answer Celiac disease (diarrhea, distension, weight loss)
"Apple core" lesion on abdominal x-ray Correct Answer
Colorectal cancer (usually left-sided)
Azurophilic granular needles in leukemic blasts Correct Answer
Auer rods (acute myelogenous leukemia, especially the
promyelocytic [M3] type)
Bacitracin response Correct Answer Sensitive: Streptocococcus
pyogenes (group A)
Resistant: Streptococcus agalactiae (group B)
"Bamboo spine" on x-ray Correct Answer Ankylosing spondylitis
(chronic inflammatory arthritis: HLA-B27)
Basophilic nuclear remnants in RBCs Correct Answer Howell-
Jolly bodies (due to splenectomy or nonfunctional spleen)
Basophilic stippling of RBCs Correct Answer Lead poisoning or
sideroblastic anemia
Bloddy tap on LP Correct Answer Subarachnoid hemorrhage
"Boot-shaped" heart on x-ray Correct Answer Tetralogy of Fallot,
RVH
Branching gram-positive rods with sulfur granules Correct Answer
Actinomyces israelii
Bronchogenic apical lung tumor Correct Answer Pancoast tumor
(can compress sympathetic ganglion and cause Horner's
syndrome)
,"Brown" tumor of bone Correct Answer Hemorrhage
(hemosiderin) causes brown color of osteolytic cysts. Due to:
1. Hyperparathyroidism
2. Osteitis fibrosa cystica
Cardiomegaly with apical atrophy Correct Answer Chagas'
disease (Trypanosoma cruzi)
Cellular crescents in Bowman's capsule Correct Answer Rapidly
progressive crescentic glomerulonephritis
"Chocolate cyst" of ovary Correct Answer Endometriosis
(frequently involves both ovaries)
Circular grouping of dark tumor cells surrounding pale neurofibrils
Correct Answer Homer Wright rosettes (neuroblastoma,
medulloblastoma, retinoblastoma)
Colonies of mucoid Pseudomonas in lungs Correct Answer
Cystic fibrosis (AR mutation to CFTR resulting in fat-soluble
vitamin deficiency and mucous plugs)
Decreased alpha-fetoprotein in amniotic fluid/maternal serum
Correct Answer Down syndrome or other chromosomal
abnormality
Degeneration of dorsal column nerves Correct Answer Tabes
dorsalis (tertiary syphilis)
Depigmentation of neurons in substantia nigra Correct Answer
Parkinson's disease (basal ganglia disorder: rigidity, resting,
tremor, bradykinesia)
, Desquamated epithelium casts in sputum Correct Answer
Curschmann's spirals (bronchial asthma; can result in whorled
mucous plugs)
Disarrayed granulosa cells in eosinophilic fluid Correct Answer
Call-Exner bodies (granulosa-theca cell tumor of the ovary)
Dysplastic squamous cervical cells with nuclear enlargment and
hyperchromasia Correct Answer Koilocytes (HPV: predisposes to
cervical cancer)
Enlarged cells with intranuclear inclusion bodies Correct Answer
"Owl's eye" appearance of CMV
Enlarged thyroid cells with ground-glass nuclei Correct Answer
"Orphan Annie" eye nuclei (papillary carcinoma of the thyroid)
Eosinophilic cytoplasmic inclusion in liver cell Correct Answer
Mallory bodies (alcoholic liver disease)
Eosinophilic cytoplasmic inclusion in nerve cell Correct Answer
Lewy body (Parkinson's disease)
Eosinophilic inclusion bodies in cytoplasm of hippocampal nerve
cells Correct Answer Rabies virus (Lyssavirus)
Extracellular amyloid deposition in gray matter of brain Correct
Answer Senile plaques (Alzhemier's disease)
Giant B cells with bilobed nuclei with prominent inclusions ("owl's
eye") Correct Answer Reed-Sternberg cells (Hodgkin's
lymphoma)
Glomerulus-like structure surrounding vessel in germ cells Correct
Answer Schiller-Duval bodies (yolk sac tumor)
WITH COMPLETE QUESTIONS AND
CORRECT ANSWERS
Anticentromere antibodies Correct Answer Scleroderma
(CREST)
Antidesmoglein (epithelial) antibodies Correct Answer
Pemphigus vulgaris (blistering)
Anti-glomerular basement membrane antibodies Correct Answer
Goodpasture's syndrome (glomerulonehpritis and hemoptysis)
Antihistone antibodies Correct Answer Drug-induced SLE
(hydralazine, isoniazid, phenytoin, procainamide)
Anti-IgG antibodies Correct Answer Rheumatoid arthritis
(systemic inflammation, joint pannus, boutonniere deformity)
Antimitochondrial antibodies (AMAs) Correct Answer Primary
biliary cirrhosis (female, cholestasis, portal hypertension)
Antineutrophil cytoplasmic antibodies (ANCAs) Correct Answer
Vasculitis (c-ANCA: Wegener's; p-ANCA: microscopic
polyangiitis, Churg-Strauss syndrome)
Antinuclear antibodies (ANAs: anti-Smith and anti-dsDNA)
Correct Answer SLE (type III hypersensitivity)
Antiplatelet antibodies Correct Answer Idiopathic
thrombocytopenic purpura (ITP)
Anti-topoisomerase antibodies Correct Answer Diffuse systemic
scleroderma
,Anti-transglutamniase/anti-gliadin/anti-endomysial antibodies
Correct Answer Celiac disease (diarrhea, distension, weight loss)
"Apple core" lesion on abdominal x-ray Correct Answer
Colorectal cancer (usually left-sided)
Azurophilic granular needles in leukemic blasts Correct Answer
Auer rods (acute myelogenous leukemia, especially the
promyelocytic [M3] type)
Bacitracin response Correct Answer Sensitive: Streptocococcus
pyogenes (group A)
Resistant: Streptococcus agalactiae (group B)
"Bamboo spine" on x-ray Correct Answer Ankylosing spondylitis
(chronic inflammatory arthritis: HLA-B27)
Basophilic nuclear remnants in RBCs Correct Answer Howell-
Jolly bodies (due to splenectomy or nonfunctional spleen)
Basophilic stippling of RBCs Correct Answer Lead poisoning or
sideroblastic anemia
Bloddy tap on LP Correct Answer Subarachnoid hemorrhage
"Boot-shaped" heart on x-ray Correct Answer Tetralogy of Fallot,
RVH
Branching gram-positive rods with sulfur granules Correct Answer
Actinomyces israelii
Bronchogenic apical lung tumor Correct Answer Pancoast tumor
(can compress sympathetic ganglion and cause Horner's
syndrome)
,"Brown" tumor of bone Correct Answer Hemorrhage
(hemosiderin) causes brown color of osteolytic cysts. Due to:
1. Hyperparathyroidism
2. Osteitis fibrosa cystica
Cardiomegaly with apical atrophy Correct Answer Chagas'
disease (Trypanosoma cruzi)
Cellular crescents in Bowman's capsule Correct Answer Rapidly
progressive crescentic glomerulonephritis
"Chocolate cyst" of ovary Correct Answer Endometriosis
(frequently involves both ovaries)
Circular grouping of dark tumor cells surrounding pale neurofibrils
Correct Answer Homer Wright rosettes (neuroblastoma,
medulloblastoma, retinoblastoma)
Colonies of mucoid Pseudomonas in lungs Correct Answer
Cystic fibrosis (AR mutation to CFTR resulting in fat-soluble
vitamin deficiency and mucous plugs)
Decreased alpha-fetoprotein in amniotic fluid/maternal serum
Correct Answer Down syndrome or other chromosomal
abnormality
Degeneration of dorsal column nerves Correct Answer Tabes
dorsalis (tertiary syphilis)
Depigmentation of neurons in substantia nigra Correct Answer
Parkinson's disease (basal ganglia disorder: rigidity, resting,
tremor, bradykinesia)
, Desquamated epithelium casts in sputum Correct Answer
Curschmann's spirals (bronchial asthma; can result in whorled
mucous plugs)
Disarrayed granulosa cells in eosinophilic fluid Correct Answer
Call-Exner bodies (granulosa-theca cell tumor of the ovary)
Dysplastic squamous cervical cells with nuclear enlargment and
hyperchromasia Correct Answer Koilocytes (HPV: predisposes to
cervical cancer)
Enlarged cells with intranuclear inclusion bodies Correct Answer
"Owl's eye" appearance of CMV
Enlarged thyroid cells with ground-glass nuclei Correct Answer
"Orphan Annie" eye nuclei (papillary carcinoma of the thyroid)
Eosinophilic cytoplasmic inclusion in liver cell Correct Answer
Mallory bodies (alcoholic liver disease)
Eosinophilic cytoplasmic inclusion in nerve cell Correct Answer
Lewy body (Parkinson's disease)
Eosinophilic inclusion bodies in cytoplasm of hippocampal nerve
cells Correct Answer Rabies virus (Lyssavirus)
Extracellular amyloid deposition in gray matter of brain Correct
Answer Senile plaques (Alzhemier's disease)
Giant B cells with bilobed nuclei with prominent inclusions ("owl's
eye") Correct Answer Reed-Sternberg cells (Hodgkin's
lymphoma)
Glomerulus-like structure surrounding vessel in germ cells Correct
Answer Schiller-Duval bodies (yolk sac tumor)
