Drugs for Peptic Ulcer
Disease and GERD
Peptic Ulcer Disease
Peptic Ulcer Disease (continued)…
• Lesion in stomach called gastric ulcer • Heliocobacter pylori (H. pylori)
• Lesion in small intestine called duodenal ulcer Primary cause of peptic ulcers
• Associated with several risk factors Gram-negative bacterium
• Other causes (contributors to ulcers and inflammation)
Family history, type O blood
Secretion of excess gastric acid
Tobacco use and caffeine
Hypo secretion of adequate mucus
Glucocorticoids and NSAIDs
, NSAIDs (most common cause in those that are not
Psychological stress infected with H. pylori)
, Gastroesophageal Reflux Gastroesophageal Reflux
Disease disease (continued)…
• Acidic stomach contents move up into esophagus
• Caused by loosening of the sphincter
between esophagus and stomach Causes intense burning (heartburn)
May lead to esophageal ulcers, esophagitis, or
strictures
• Associated with obesity
• Lifestyle changes can improve GERD symptoms
Treatment of Gastroesophageal Treatment of Peptic Ulcer
Reflux Disease (continued)… Disease
• Combination of lifestyle changes and
• Drug classes
pharmacotherapy best
H2 receptor blockers
• Treatment goals
Antacids Eliminate infection by H. pylori
Proton pump inhibitors Promote ulcer healing
Disease and GERD
Peptic Ulcer Disease
Peptic Ulcer Disease (continued)…
• Lesion in stomach called gastric ulcer • Heliocobacter pylori (H. pylori)
• Lesion in small intestine called duodenal ulcer Primary cause of peptic ulcers
• Associated with several risk factors Gram-negative bacterium
• Other causes (contributors to ulcers and inflammation)
Family history, type O blood
Secretion of excess gastric acid
Tobacco use and caffeine
Hypo secretion of adequate mucus
Glucocorticoids and NSAIDs
, NSAIDs (most common cause in those that are not
Psychological stress infected with H. pylori)
, Gastroesophageal Reflux Gastroesophageal Reflux
Disease disease (continued)…
• Acidic stomach contents move up into esophagus
• Caused by loosening of the sphincter
between esophagus and stomach Causes intense burning (heartburn)
May lead to esophageal ulcers, esophagitis, or
strictures
• Associated with obesity
• Lifestyle changes can improve GERD symptoms
Treatment of Gastroesophageal Treatment of Peptic Ulcer
Reflux Disease (continued)… Disease
• Combination of lifestyle changes and
• Drug classes
pharmacotherapy best
H2 receptor blockers
• Treatment goals
Antacids Eliminate infection by H. pylori
Proton pump inhibitors Promote ulcer healing
