ONC EXAM 2: CRC QUESTIONS AND ANSWERS 100% VERIFIED

ONC EXAM 2: CRC QUESTIONS AND ANSWERS 100% VERIFIED These monoclonal antibodies target EGFR and are only effective with wildtype KRAS - answerCetuximab Panitumumab These monoclonal antibodies target and inhibit VEGF - answerBevacizumab Ramucirumab This monoclonal antibody acts as a VEGF decoy receptor - answerZiv-Aflibercept These mAbs are checkpoint inhibitors that target PD-1 and are effective in treating MSI high CRC - answerPembrolizumab Nivolumab This mAb is a checkpoint inhibitor that targets CTLA4 and is effective in treating MSI high CRC - answerIpilimumab This mAb is a checkpoint inhibitor that targets PD1 and is effective in treating deficient MMR aka dMMRr - answerDostarlimab This small molecule tyrosine kinase inhibitor targets the VEGF receptor (taken orally) - answerRegorafenib This is the only BRAF inhibitor approved for the treatment of CRC. (PO for metastatic CRC with the rare BRAF V600E mutation) - answerEncorafenib *ENCORE for the only B approved to tx CRC First line Chemo regimen for CRC - answerFOLFOX 5FU, leucovorin, oxaliplatin (Antimetabolite, folinic acid, platinum alkylating agent)