Braun Applied Pathophysiology Chapter 3 Inflammation and Tissue Repair (SCORE A+ GUARANTEED)

Proliferative Phase part 1 -Clear the debris using neutrophils and macrophages to engulf, digest, and remove debris. Healing can't begin until necrotic cells are removed Restore Structural Integrity-Restore Structural integrity- tissue lysis (breakdown) occurs; growth factors and matrix proteins responsible for rebuilding ECM (structures that cells-basement membrane and connective tissue layers) -Basement Membrane- must be restored before re-epithelialization occurs What are the body's three major lines of defense? 1. First line of defense-skin and mucous membranes comprise a physical and chemical barrier invasion. 2. Second line of defense-(inflammatory response) nonspecific-identical response regardless of the cause of injury 3. Third line of defense- (immune response) wages a specific defense depending on the type of invader Acute Inflammation Triggered by tissue injury and is essential for healing Acute Inflammation Is an expected body response to injury that is abrupt in onset