Pathophysiology exam review
Parachymal>>> function type of cell
stromal>>> provide structure/support for cell
labile>>> this type of cell can regenerate quickly (dividing and replicating- skin is an example)
stable>>> this type of cell stops dividing and replicating when growth stops
fixed>>> can not divide, replicate, or regenerate when injured or harmed
fibrous tissue repair>>> injured tissue is replaced by connective tissue ( severe injury)
granulation>>> development of red, moist tissue made up of new blood vessels, indicating the
progression of wound healing
angiogenesis>>> formation of new capillaries
fibrogenesis>>> activation of fibroblasts and formation of extracellular matrix
scar tissue>>> during the formation of _____ fibroblasts are moving and depositing in places
chemical mediators>>> a chemical released in the body during an inflammatory response or immune
response
primary intention>>> wounds that heal under conditions of minimal tissue loss, produce minimal
scarring, and require no stitches
secondary intention>>> Wound healing with extensive cell and tissue loss, new tissue required, will scar
basement membrane>>> membrane that surrounds and protects cells
interstitial matrix>>> Present in the spaces between cells the connective tissue and between the
epithelium and the supporting cells of the blood vessels.
inflammation>>> phase of wound healing that starts at the time of the injury: prepares wound for
healing, neutrophils come first, macrophages come 2nd 24 hours later
proliferative>>> phase of wound healing that comes within 2-3 days of the injury: fibroblasts are the key
cells involved and the goal is to build new tissue
Epithelialization>>> stage of wound healing in which epithelial cells form across the surface of a wound (
final component of proliferative phase)
, remodeling>>> begins 3 weeks after initial injury- can last up to 6 months or longer. Primary purpose is
to synthesize collagen & lysis of fibrosis
Fibrous (structural) proteins>>> component of extracellular matrix (ECM) that includes collagen and
elastin fibers
waterhydrated gels>>> component of ECM that contains proteoglycans and hyaluronic acid
morbidity>>> level of impaired function or disability
mortality>>> amount of people that die
vaccines>>> primary level of disease prevention
sequalae>>> a problem resulting from a disease or injury (expected)
complications>>> problems that are not supposed to happen- preventable
cellular stress>>> physical change in cellular environment (external or internal)
atrophy>>> cell shrinks
hypertrophy>>> cell expands
hyperplasia>>> increase number of cells
metaplasia>>> cell changes structure
dysplasia>>> precursor for cancer, cells are unorganized
disuse>>> cause of atrophy where muscles aren't used and become weak and shrink
denervation>>> cause of atrophy where motor nerve isn't working anymore or stimulating muscle
dystrophic>>> injured or dead cells release calcium, which is deposited in surrounding tissue (disease
related)
metastic>>> no tissue damage, but increased calcium salts in the blood leads to calcium deposits in
tissues (systemic, microscopic)
blunt>>> tissue is torn, sheared or crushed
- contusions, hematomas, abrasions, lacerations, fractures
sharp>>> incised wound, stab wounds, puncture wounds
low intensity heat injury>>> forget to put oven mitt on and burn yourself, sunburn. some cell membrane
damage but at a low level
Parachymal>>> function type of cell
stromal>>> provide structure/support for cell
labile>>> this type of cell can regenerate quickly (dividing and replicating- skin is an example)
stable>>> this type of cell stops dividing and replicating when growth stops
fixed>>> can not divide, replicate, or regenerate when injured or harmed
fibrous tissue repair>>> injured tissue is replaced by connective tissue ( severe injury)
granulation>>> development of red, moist tissue made up of new blood vessels, indicating the
progression of wound healing
angiogenesis>>> formation of new capillaries
fibrogenesis>>> activation of fibroblasts and formation of extracellular matrix
scar tissue>>> during the formation of _____ fibroblasts are moving and depositing in places
chemical mediators>>> a chemical released in the body during an inflammatory response or immune
response
primary intention>>> wounds that heal under conditions of minimal tissue loss, produce minimal
scarring, and require no stitches
secondary intention>>> Wound healing with extensive cell and tissue loss, new tissue required, will scar
basement membrane>>> membrane that surrounds and protects cells
interstitial matrix>>> Present in the spaces between cells the connective tissue and between the
epithelium and the supporting cells of the blood vessels.
inflammation>>> phase of wound healing that starts at the time of the injury: prepares wound for
healing, neutrophils come first, macrophages come 2nd 24 hours later
proliferative>>> phase of wound healing that comes within 2-3 days of the injury: fibroblasts are the key
cells involved and the goal is to build new tissue
Epithelialization>>> stage of wound healing in which epithelial cells form across the surface of a wound (
final component of proliferative phase)
, remodeling>>> begins 3 weeks after initial injury- can last up to 6 months or longer. Primary purpose is
to synthesize collagen & lysis of fibrosis
Fibrous (structural) proteins>>> component of extracellular matrix (ECM) that includes collagen and
elastin fibers
waterhydrated gels>>> component of ECM that contains proteoglycans and hyaluronic acid
morbidity>>> level of impaired function or disability
mortality>>> amount of people that die
vaccines>>> primary level of disease prevention
sequalae>>> a problem resulting from a disease or injury (expected)
complications>>> problems that are not supposed to happen- preventable
cellular stress>>> physical change in cellular environment (external or internal)
atrophy>>> cell shrinks
hypertrophy>>> cell expands
hyperplasia>>> increase number of cells
metaplasia>>> cell changes structure
dysplasia>>> precursor for cancer, cells are unorganized
disuse>>> cause of atrophy where muscles aren't used and become weak and shrink
denervation>>> cause of atrophy where motor nerve isn't working anymore or stimulating muscle
dystrophic>>> injured or dead cells release calcium, which is deposited in surrounding tissue (disease
related)
metastic>>> no tissue damage, but increased calcium salts in the blood leads to calcium deposits in
tissues (systemic, microscopic)
blunt>>> tissue is torn, sheared or crushed
- contusions, hematomas, abrasions, lacerations, fractures
sharp>>> incised wound, stab wounds, puncture wounds
low intensity heat injury>>> forget to put oven mitt on and burn yourself, sunburn. some cell membrane
damage but at a low level
