WGU C785 Biochemistry OA NEW 2023 – 2024 Already Passed With complete solution

Which level of protein structure is disrupted through the hydrolysis of peptide bonds? Quaternary Tertiary Primary Secondary - CORRECT ANSWER Primary The primary structure of a protein is the sequence of amino acids held together by peptide bonds. Peptide bonds are formed by dehydration reactions and disrupted by hydrolysis. A mutation in the beta-hemoglobin gene, which results in the replace-ment of the amino acid glutamate in position 6 with the amino acid va-line, leads to the development of sickle cell anemia. The structures of glutamate and valine are shown below. If the beta hemoglobin gene in a patient with sickle-cell anemia were to be edited so that the valine in position 6 was replaced with a different amino acid, which replacement for valine would be expected to have the best clinical outcome, in theory, for the patient? (Assume the va-line can potentially be replaced with any amino acid other than gluta-mate.) -