Epiphany term organic chemistry summary

Summary
Notes
term 2
Organic

, Summary notes
Nucleophilic attack


Ni als reaction
formards

↳ ->
mit
Need a strong nucleophile which is a
poor It

so green recution doesn't happen.
i.e need strongly basic vicleophiles, know
this by looking
at pka's.




Organometallics
~organomettalic the
if the seperated then

me-↳x
not
polar aprotic
ether steps are
1 MeLi, THE solvent,
-
0




n-hn
->

2) 120
I
Li-for -> Me-, Lion

second

1
-non be formed
1) LiMe, THF step
will



Liverp e m
basic albosuder im

, Organometallics-> trignard reagents

1)
re
PhMgr, It

*P ->
120 Way to
form a c-c



y
n bond if need to add

Mg to a molecule. Require
phi a c 0
=


group
to attack.




also form Linear, less strichinderance
can acetylide anions ->
but less basic




Buri)
Buli is
basic, oka-so
I
MH ↑ or
n =H is li En
-

H20




↓ ↑
-I
-




~ufon


*-

, THE
form organometallic, metal with the solent, eg
to use




Addition of water ncleophiles to aldehydes and ketones


~"For
Role -
to ->


e -
no



n
on
x

Hydrate
-Br kelones -> disfavour forming catalyst ->
/formaldehyde
hydrate catalyst
without
hydrates
n aldehyde => 50:50 product and reactants



formaldehyde favourable reacts with water
*u very
=> ->


without a catalyst
n