Sepsis and Systemic Infections
Mortality Increases in Septic Shock:
Definitions:
Systemic infection = sepsis - A systemic inflammation stemming from an infectious
focus with systemic signs of infection
Bacteremia occurs when bacteria enter the bloodstream. Bacteremia may cause no
symptoms and resolve without treatment, or it may produce fever and other symptoms
of infection. In some cases, bacteremia leads to septic shock, a potentially life-
threatening condition.
Bloodstream infection – an infection that is propagating through the blood stream
Friday
SIRS - Systemic inflammatory response syndrome:
defined as a clinical response arising from nonspecific insult including ≥ 2 of the
following:
Temperature ≥ 38º C or ≤ 36º C.
HR ≥ 90 beats/min
Respirations ≥ 20/min or arterial pCO2 ≤ 4.3 kPa (32mm Hg)
WBC ≥ 12000/mm2 or ≤ 4000/mm2 or ≥ 10% immature neutrophils
1
, Classification:
Sepsis - SIRS with documented infection
Severe sepsis – sepsis with organ failure, tisularhypoperfusion or hypotension –
mortality 25-30%
Septic shock – sepsis with hypotension and tisularhypoperfusion despite
resuscitation – mortalitaty40-70%
Refractary septic shock – septic shock more than anhour nonresponsive to
resuscitation andvasopressors
Rangel Fausto - SIRS-sepsis- severe sepsis –septic shock
Progression:
2
Mortality Increases in Septic Shock:
Definitions:
Systemic infection = sepsis - A systemic inflammation stemming from an infectious
focus with systemic signs of infection
Bacteremia occurs when bacteria enter the bloodstream. Bacteremia may cause no
symptoms and resolve without treatment, or it may produce fever and other symptoms
of infection. In some cases, bacteremia leads to septic shock, a potentially life-
threatening condition.
Bloodstream infection – an infection that is propagating through the blood stream
Friday
SIRS - Systemic inflammatory response syndrome:
defined as a clinical response arising from nonspecific insult including ≥ 2 of the
following:
Temperature ≥ 38º C or ≤ 36º C.
HR ≥ 90 beats/min
Respirations ≥ 20/min or arterial pCO2 ≤ 4.3 kPa (32mm Hg)
WBC ≥ 12000/mm2 or ≤ 4000/mm2 or ≥ 10% immature neutrophils
1
, Classification:
Sepsis - SIRS with documented infection
Severe sepsis – sepsis with organ failure, tisularhypoperfusion or hypotension –
mortality 25-30%
Septic shock – sepsis with hypotension and tisularhypoperfusion despite
resuscitation – mortalitaty40-70%
Refractary septic shock – septic shock more than anhour nonresponsive to
resuscitation andvasopressors
Rangel Fausto - SIRS-sepsis- severe sepsis –septic shock
Progression:
2
