Manufacture of organic solid (aspirin) Unit 4 assignment C
UNIT 4C _
MANUFACTURING AN
ORGANIC SOLID
Making Aspirin
, Manufacture of organic solid (aspirin) Unit 4 assignment C
Contents
Title........................................................................................................................................................2
Introduction...........................................................................................................................................2
Method..................................................................................................................................................3
Risk assessment.....................................................................................................................................6
Results...................................................................................................................................................7
Analysis & Evaluation.............................................................................................................................9
Conclusion...........................................................................................................................................12
Case study............................................................................................................................................13
References...........................................................................................................................................15
1
, Manufacture of organic solid (aspirin) Unit 4 assignment C
Title
Preparation of Aspirin
Introduction
In this report we will be making aspirin and it is made by reacting 2-hydroxybenzic acid with
ethanoic anhydride, this ethanoic acid bi-product remains in solution so the solid product
can be separated from the reaction mixture. The product was made under reflux because
we needed to heat it up.
Aspirin is synthesized by esterification reaction of salicylic acid and acetic acid in the
presence of phosphoric acid. Phosphoric acid acts as a catalyst and fastens the speed of
reaction. It protonates the carboxyl group of salicylic acid and flavours the esterification
reaction to produce aspirin and ethanoic acid.
Recrystallisation is a purification method that involves dissolving both the chemical and the
impurity in a solvent and then reheating the solution. It is critical to make sure that products
are free of contaminants. Purification is likely to be required once an organic solid has been
created. The method of recrystallization is one method to remove impurities. Various
compounds have different solubilities in a solvent at different temperatures, according to
the principle. Due to the product's and impurity's different solubilities in hot and cold
solvents, separation is possible.
The purity of the product is measured in many ways such as the measurement of melting
point and this is known of its accuracy for most elements and compounds and, like the
boiling point it can be compared to the literature value. Another way is to do the Thin Layer
Chromatography (TLC). By comparing a chemical's chromatogram to that of a pure known
compound, you may identify it. Their retention factors Rf can also be used to identify them.
The distance the solvent has travelled up the TCL plates and the distance each spot has
travelled up to the TLC plate are measured.
2
UNIT 4C _
MANUFACTURING AN
ORGANIC SOLID
Making Aspirin
, Manufacture of organic solid (aspirin) Unit 4 assignment C
Contents
Title........................................................................................................................................................2
Introduction...........................................................................................................................................2
Method..................................................................................................................................................3
Risk assessment.....................................................................................................................................6
Results...................................................................................................................................................7
Analysis & Evaluation.............................................................................................................................9
Conclusion...........................................................................................................................................12
Case study............................................................................................................................................13
References...........................................................................................................................................15
1
, Manufacture of organic solid (aspirin) Unit 4 assignment C
Title
Preparation of Aspirin
Introduction
In this report we will be making aspirin and it is made by reacting 2-hydroxybenzic acid with
ethanoic anhydride, this ethanoic acid bi-product remains in solution so the solid product
can be separated from the reaction mixture. The product was made under reflux because
we needed to heat it up.
Aspirin is synthesized by esterification reaction of salicylic acid and acetic acid in the
presence of phosphoric acid. Phosphoric acid acts as a catalyst and fastens the speed of
reaction. It protonates the carboxyl group of salicylic acid and flavours the esterification
reaction to produce aspirin and ethanoic acid.
Recrystallisation is a purification method that involves dissolving both the chemical and the
impurity in a solvent and then reheating the solution. It is critical to make sure that products
are free of contaminants. Purification is likely to be required once an organic solid has been
created. The method of recrystallization is one method to remove impurities. Various
compounds have different solubilities in a solvent at different temperatures, according to
the principle. Due to the product's and impurity's different solubilities in hot and cold
solvents, separation is possible.
The purity of the product is measured in many ways such as the measurement of melting
point and this is known of its accuracy for most elements and compounds and, like the
boiling point it can be compared to the literature value. Another way is to do the Thin Layer
Chromatography (TLC). By comparing a chemical's chromatogram to that of a pure known
compound, you may identify it. Their retention factors Rf can also be used to identify them.
The distance the solvent has travelled up the TCL plates and the distance each spot has
travelled up to the TLC plate are measured.
2
