Micro RNA and Wound Healing
INTODUCTION RESULTS
Micro RNA’s (miRNA) are small non-coding proteins Dynamic miRNome changes during the
about 22-nt long. Their functions are based around the inflammatory phase of human skin wound healing.
degradation of mRNA and post-translational gene miR-132 expression is induced by TGF-β in
modifications. Here Li, et al analyse the role of miRNA keratinocytes.
within wound healing. Characterization of the transcriptome regulated by
During the inflammatory phase of wound healing miR-132 in keratinocytes.
epidermal keratinocytes induce the release of miR-132 suppresses keratinocyte chemokine
production by regulating the NF-κB pathway.
inflammatory cytokines such as CXC chemokine ligand 1
miR-132 promotes keratinocyte growth by
(CXCL1) and IL-8.
regulating STAT3 and ERK pathways.
miRNA-132 has been shown to be a major molecular HB-EGF is targeted by miR-132 in keratinocytes.
regulator in human keratinocytes with a crucial role in Lack of miR-132 delays skin wound healing in vivo.
facilitating the shift from the inflammatory phase to the Inhibition of miR-132 delays reepithelialisation of
proliferation phase. human ex vivo skin wounds.
CONCLU
miRNA-1
healing c
growth f
driving fa
in increa
colleagu
overexpr
INTODUCTION RESULTS
Micro RNA’s (miRNA) are small non-coding proteins Dynamic miRNome changes during the
about 22-nt long. Their functions are based around the inflammatory phase of human skin wound healing.
degradation of mRNA and post-translational gene miR-132 expression is induced by TGF-β in
modifications. Here Li, et al analyse the role of miRNA keratinocytes.
within wound healing. Characterization of the transcriptome regulated by
During the inflammatory phase of wound healing miR-132 in keratinocytes.
epidermal keratinocytes induce the release of miR-132 suppresses keratinocyte chemokine
production by regulating the NF-κB pathway.
inflammatory cytokines such as CXC chemokine ligand 1
miR-132 promotes keratinocyte growth by
(CXCL1) and IL-8.
regulating STAT3 and ERK pathways.
miRNA-132 has been shown to be a major molecular HB-EGF is targeted by miR-132 in keratinocytes.
regulator in human keratinocytes with a crucial role in Lack of miR-132 delays skin wound healing in vivo.
facilitating the shift from the inflammatory phase to the Inhibition of miR-132 delays reepithelialisation of
proliferation phase. human ex vivo skin wounds.
CONCLU
miRNA-1
healing c
growth f
driving fa
in increa
colleagu
overexpr
