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Summary

Summary iGCSE Edexcel DNA and Inheritance - Notes

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just your general genetics notes with DNA, protein synthesis, cell division, mutation, natural selection, etc

Institution
GCSE
Module
Biology

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D




N

A

,DNA ,
Genes & Genome

→ Genetic Information of the Ccd

① cell nucleus
membrane bonded
organelle
in
eukaryotic cells

contain genetic material

② chromosome

structure
composed of a
long molecule
of
DNA
E coiled & condensed amowd proteins
organised compact way
in
very
a




③ DNA -

Deoxy ribonucleic Acid ← 2min
length
stores
genetic information " "man >
determines inherited characteristics


④ Gene
a
length of DNA at a
specific place on a




chromosome
② codes
for a
specific protein
⑤ Genome
's
an
organism complete set of DNA
all the
including genes
needed to build
contains all the
and maintain
information
the
organism

,→
summary
DNA is a chemical found inside the
nucleus .
As an
important molecule ,
it
needs to looked it is
packaged
be
after so


into structures called chromosomes .
A section
of called
DNA that codes for a trait is a


Humans have 23
gene .




pairs of chromosomes .




In each pair there
copy of the
is one


chromosome
from each
of our
parents .




The genome the the
is name
for all
material
genetic found in the
organism .




Most cells have the
copy of
an entire
entire their nucleus
genome in .




-

, → all '
instructions are written
organisms
in


4 letters A T

c←>G

& full set 23 Chromosomes human
karyotype *
of of
=


pairs

→ structure
of a DNA molecule

consists strands
of 2
long connected to

each other
↳ double helix
coiled to form a




link between strands done
is
by Hz bonds

between paired bases

Adenine IA )
[ Thymine A=T
-




a)
CIG
(c)
Cytosine
[
-




-
Guanine (G)
sugar phosphate
backbone

§ bases ( paned )
sugar

§
)
c
G ( deoxyribose
→ phosphate

T


A
Hz Bonds

* Antiparallel DNA strands *



?⃝

,RNA & Protein synthesis
→ DNA & the code

proteins are
responsible for the characteristics 1
-




traits
of an
organism
acids
proteins long sequence of amino
- :




② 20 acids
different amino


the order that these bases
along
-
come on



DNA is the
genetic code
↳ DNA molecule (gene )
a section
of bases that
comprises a
sequence of
the code (
are
recipe)
② how to make certain
protein
on a




sequence of →
the sequence of
the bases amino acids
of the
that gene
protein
encodes
for
combination
of 3 bases order
in a
specific
-




② Codon

↳ the code codon acid
unit
of → 1 = I amino




-


64 possible different codons

acids & STOP codons
↳ codes
for 20 amino


↳ some amino acids
are coded
by more


↳than
codons
one codon
are redundant

,→ Protein synthesis -



Transcription nucleus



The DNA has the nucleus the
••
stay
to in so

onto
code is
first copied another molecule
↳ RNA ( mRNA )
made
* proteins are

in the *
① DNA Unzips cytoplasm
* DNA is too big
-
code can be accessed to leave nucleus t

will bind to the opened DNA
special proteins
-




② starts to assemble a new molecule → RNA

according to DNA
sequence
DNA $ RNA }



}
deoxyribose ribose
sugar
sugar mRNA (
messenger )
nitrogen nitrogen bases /
bases ↳ a. u ; e. a
- tRNA (
transfer,
↳ AM :c , G
u : Uracil

double single
stranded stranded
( double helix )

② DNA is transcribed into mRNA
out the
mRNA is small
enough to
pass of
-




i. nucleus into the
'
cytoplasm
.
-
-



÷, translation

, D- cytoplasm
→ Protein Synthesis -
Translation
in the
••
mRNA then attaches to ribosomes cytoplasm
↳ read the code

↳ assemble acids tRNA
the
right amino
using

① code is transcribed into mRNA

② taken to
cytoplasm
① code is translated
② converted acids
into a
sequence of amino



A ribosome 3 bases at a time

-
bind to mRNA
-
read the code

tRNA
-




found free in
cytoplasm
-
clover
leaf shaped
3 bases at the bottom
Complimentary
-




② codon mRNA
match to
corresponding
on



* anticodon *
-

exposed bases at the
opposite end
② acid
corresponds to a
specific amino
-
reads a codon at a time


corresponding tRNA complimentary
-
binds to the codon


↳ happen with every codon


-




first ERNA is released
after the second birds

② ribosome moves
along to read the next codon

-

continues until STOP codon is reached

, ③ protein is
formed
-




folded into 3D shape
mRNA released ribosome to be reused
by
-




& Model Answer it

Q Outline the
.




process of protein synthesis
A. The DNA code is
copied into mRNA ,
this is called


transcription .
It
happy in the
nucleus .

C U replacing -1 )
The mRNA leaves the nucleus and goes
to
cytoplasm ,




where the ribosome bonds to the mRNA .




The ribosome reads the codons ,
which consists


ofsequence of 3 bases
a / nucleotides .




The tRNA with set
of anticodon
a
complimentary
binds to the codon .
One codon then translated
is

to one amino acid .




added to the
The amino acid is then protein
and the the
sequence ribosome moves
along
mRNA to read the next codon .




This is translation
process

, Transcription summary
① DNA unwinds

attaches to DNA
① RNA polymerase enzyme
transcribed
being
③ Complimentary RNA nucleotides line
up opposite
the DNA bases


④ RNA
polymerase joins the RNA nucleotides
together

⑤ a strand of mRNA is
formed
⑥ mRNA →
cytoplasm
Translation summary
① ribosome attaches to mRNA

① correct tRNA molecule & its anticodon
at the ribosome & with
arrives
pairs up
the codon


③ next tRNA & its amino acid arrives at the ribosome



④ 2 amino acids
join together
⑤ the ribosome moves
alongline
the mRNA &
The next tRNA molecules up

⑥ protein grows until STOP codon


⑦ mRNA leaves and returns to
repeat
Protein
Synthesis

, Meoisis & Meiosis

→ Diploid V5 Haploid
Diploid cells contains
:
pairs of chromosomes
-




( 23 humans )
pairs for
-




Haploid cells : contains
single chromosomes


É
( 23 SINGLE chromosomes for E)
gametes diploid ←

* 2
gametes frm zygote to form embryo *
a



↳ if gametes diploid
are
zygotes will have
,


46
pairs of chromosomes ,
double the aunt

an human embryo needs


→ Meiosis
-


cell division that makes gametes
② results in 4
daughter cells
-


haploid
-




genetically non -

identical to each other &

parent cells

① DNA is replicated
② Chromosomes appear
cell
③ Chromosomes align in the middle of the

olhomologus side
by side

④ Homologues chromosomes are
pulled to
opposite
sides &
separated

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