1|Page
NR546 Midterm Exam
2026|Comprehensive Questions And
Answers
client who is a poor metabolizer: - correct-answer - has a lower concentration of
the necessary enzyme to metabolize a drug, which results in higher blood
concentrations of the drug.
-increase the risk of side effects and adverse reactions
Why is trazodone not used as a front-line antidepressant - correct-answer - Its
antidepressant that has a secondary effect of blocking histamine and adrenergic
receptors
-causes sedation and somnolence and as a result
*often used as an adjunct in therapy when a depressed patient has difficulty
sleeping
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effect on neurotransmitters and side effects: Selective Serotonin Reuptake
Inhibitors (SSRIs) - correct-answer - Inhibits the reuptake of serotonin, which can
cause nausea, agitation, headache, and sexual dysfunction
effect on neurotransmitters and side effects: Serotonin and Norepinephrine
Reuptake Inhibitors (SNRIs) - correct-answer - Inhibits the reuptake of serotonin
and norepinephrine, which can cause nausea, sweating, insomnia, tremors, sexual
dysfunction
effect on neurotransmitters and side effects: Tricyclic Antidepressants - correct-
answer - -Inhibits the reuptake of serotonin and norepinephrine, which can cause
sexual dysfunction
-Blocks norepinephrine receptors, which can cause hypotension and tachycardia
-Blocks histamine receptors, which can cause sedation and weight gain
-Blocks acetylcholine receptors, which can cause dry mouth, constipation, blurred
vision, and urinary retention
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effect on neurotransmitters and side effects: Monoamine Oxidase Inhibitors
(MAOIs) - correct-answer - Increases norepinephrine and serotonin by inhibiting
the enzyme that inactivates it, which can cause sedation, dizziness, sexual
dysfunction, and hypertensive crisis
effect on neurotransmitters and side effects: Benzodiazepines - correct-answer -
Increases the receptor affinity for GABA, which can cause dependence and
confusion
effect on neurotransmitters and side effects: Bupropion - correct-answer -
Inhibits the reuptake of norepinephrine and dopamine, which can cause
insomnia, dry mouth, tremors, and seizures
antagonist - correct-answer - causes a conformational change that stabilizes the
receptor in the baseline state and thus is "silent."
, 4|Page
-blocks the action of a neurotransmitter
agonists - correct-answer - fully stimulate G-protein-linked receptors
partial agonists - correct-answer - stimulate receptors to a lesser degree than an
agonist or natural neurotransmitter
SSRIs, SNRIs, and tricyclic antidepressants increase ________ levels.
___________ do not impact serotonin levels. - correct-answer - increase
serotonin levels.
Benzodiazepines do not impact serotonin levels.
Is nicotine an inducer or an inhibitor of the CYP 1A2 enzyme? - correct-answer -
inducer
NR546 Midterm Exam
2026|Comprehensive Questions And
Answers
client who is a poor metabolizer: - correct-answer - has a lower concentration of
the necessary enzyme to metabolize a drug, which results in higher blood
concentrations of the drug.
-increase the risk of side effects and adverse reactions
Why is trazodone not used as a front-line antidepressant - correct-answer - Its
antidepressant that has a secondary effect of blocking histamine and adrenergic
receptors
-causes sedation and somnolence and as a result
*often used as an adjunct in therapy when a depressed patient has difficulty
sleeping
,2|Page
effect on neurotransmitters and side effects: Selective Serotonin Reuptake
Inhibitors (SSRIs) - correct-answer - Inhibits the reuptake of serotonin, which can
cause nausea, agitation, headache, and sexual dysfunction
effect on neurotransmitters and side effects: Serotonin and Norepinephrine
Reuptake Inhibitors (SNRIs) - correct-answer - Inhibits the reuptake of serotonin
and norepinephrine, which can cause nausea, sweating, insomnia, tremors, sexual
dysfunction
effect on neurotransmitters and side effects: Tricyclic Antidepressants - correct-
answer - -Inhibits the reuptake of serotonin and norepinephrine, which can cause
sexual dysfunction
-Blocks norepinephrine receptors, which can cause hypotension and tachycardia
-Blocks histamine receptors, which can cause sedation and weight gain
-Blocks acetylcholine receptors, which can cause dry mouth, constipation, blurred
vision, and urinary retention
,3|Page
effect on neurotransmitters and side effects: Monoamine Oxidase Inhibitors
(MAOIs) - correct-answer - Increases norepinephrine and serotonin by inhibiting
the enzyme that inactivates it, which can cause sedation, dizziness, sexual
dysfunction, and hypertensive crisis
effect on neurotransmitters and side effects: Benzodiazepines - correct-answer -
Increases the receptor affinity for GABA, which can cause dependence and
confusion
effect on neurotransmitters and side effects: Bupropion - correct-answer -
Inhibits the reuptake of norepinephrine and dopamine, which can cause
insomnia, dry mouth, tremors, and seizures
antagonist - correct-answer - causes a conformational change that stabilizes the
receptor in the baseline state and thus is "silent."
, 4|Page
-blocks the action of a neurotransmitter
agonists - correct-answer - fully stimulate G-protein-linked receptors
partial agonists - correct-answer - stimulate receptors to a lesser degree than an
agonist or natural neurotransmitter
SSRIs, SNRIs, and tricyclic antidepressants increase ________ levels.
___________ do not impact serotonin levels. - correct-answer - increase
serotonin levels.
Benzodiazepines do not impact serotonin levels.
Is nicotine an inducer or an inhibitor of the CYP 1A2 enzyme? - correct-answer -
inducer
