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WGU D115 Advanced Pathophysiology | Exam Q&A | 2026/27

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Verified exam questions and answers for WGU D115 Advanced Pathophysiology OA and Pre-OA exams from the 2026/27 academic year. Covers high-yield clinical scenarios including teratogenic medications, genetic screening, neonatal immunity, hereditary angioedema, Down syndrome complications, multiple sclerosis, retinoblastoma, and peripheral nervous system disorders. Ideal for exam preparation—fully solved with detailed explanations to help identify frequently tested pathophysiology concepts and clinical applications.

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WGU D115 OA AND PRE-OA
EXAM ACTUAL EXAM 2026 TEST
COMPREHENSIVE QUESTIONS
AND VERIFIED ANSWERS
(DETAILED & ELABORATED)
100% SOLVED 2026

An advanced practice registered nurse (APRN) is consulting with a teen patient who has recently
learned that she is pregnant. The APRN knows that a certain medication taken by the patient
can contribute to the development of congenital malformations in the fetus. The APRN reviews
the patient's current medication list and finds one medication that is a concern.

Which medication is the APRN concerned about? - ANSWER-Retinoic acid



A newborn's screening for cystic fibrosis is positive. An advanced practice registered nurse
(APRN) is reviewing screening results and taking a comprehensive genetic screening of the
parents. The APRN asks the parents questions to help determine the transmission of this
disease.

Which question should the APRN ask? - ANSWER-"Are you both the genetic donor parents?"



A 30-day-old infant presents to the emergency room with decreased oral intake, decreased
urine output, and a fever of 101.8. The infant is admitted for further evaluation with a workup
to include a blood culture, a urine culture, a spinal tap, and a chest X-ray.

Which issue of innate immunity, as it relates to neonates, is of concern? - ANSWER-Relative
deficiency of factor B



A 12-year-old African American patient presents with unilateral eye swelling and lower lip
swelling. The patient's parent reports that the swelling is spontaneous and resolves over several

, days. The patient does not have complaints of fever, hives, or vomiting. Serum lab results show
hyperactivation of three plasma protein systems. The APRN suspects hereditary angioedema.

What is the cause of the genetic defect suspected in this situation? - ANSWER-C1 esterase
inhibitor



The parent of a child diagnosed with Down syndrome expresses concerns about the child's
recurrent respiratory tract infections to an advanced practice registered nurse (APRN). The
infections have occurred regularly since birth.

What should the APRN tell the parent is the underlying cause of this illness? - ANSWER-
Gastroesophageal reflux disease causes aspiration of thin fluids.



A 36-year-old patient is being seen by an advanced practice registered nurse (APRN) in a
primary care clinic for the first time. The patient reports feeling depressed due to a major life
change. Additional symptoms include weight gain, sedentary activity, and insomnia. The APRN
plans on providing the patient with several exercises to reduce the physiological effect of stress.

Why is the APRN concerned about relieving this emotional response? - ANSWER-It decreases
glucose uptake.



An 80-year-old patient brings her grandchildren with her to a routine medical appointment. The
patient has moderate chronic obstructive pulmonary disease (COPD) and is concerned about
developing pneumonia because of its increased incidence at the senior center.

What should the nurse practitioner recommend for this patient? - ANSWER-Getting an annual
influenza vaccine



An advanced practice nurse (APRN) is working with a patient who is choosing to undergo breast
removal due to family history of breast cancer. The patient's genetic testing revealed an
abnormal BRCA1. The patient shares with the APRN that she is relieved that she will not need to
worry about cancer once the breast tissue is removed. The APRN proceeds to educate the
patient about additional risks.

Which other type of cancer is the patient at risk for developing? - ANSWER-Ovarian

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