Blood and Marrow Transplant Certified Nurse
(BMTCN)EXAM LATEST WITH ACTUAL QUESTIONS
AND CORRECT VERIFIED ANSWERS/ALREADY
GRADED A+ 100% GUARANTEED TO PASS
CONCEPTS(ALL WHAT YOU NEED) LATEST EDITION
,I. Foundations of Transplant (Questions 1-20)
1. A patient with acute myeloid leukemia (AML) with a monosomal karyotype is being evaluated for allogeneic transplant. The patient has no
matched sibling donor. Which alternative donor source is associated with the most rapid neutrophil engraftment?
A) 10/10 Matched Unrelated Donor (MUD) marrow
B) 5/10 Haploidentical peripheral blood stem cells
C) 6/6 Cord blood unit
D) 9/10 Mismatched Unrelated Donor (MMUD) marrow
Answer: B
Rationale: Haploidentical transplants using peripheral blood stem cells (PBSCs) typically result in neutrophil engraftment within 14-21 days,
comparable to matched related donors. Cord blood engraftment is significantly slower due to lower cell dose. Marrow grafts (MUD/MMUD)
engraft slower than PBSCs.
,2. A patient is undergoing HLA typing for an allogeneic transplant. Which HLA loci are considered most critical for matching to minimize the risk
of severe acute graft-versus-host disease (aGVHD)?
A) HLA-A, HLA-B, HLA-DR
B) HLA-C, HLA-DQ, HLA-DP
C) HLA-A, HLA-DR, HLA-DP
D) HLA-B, HLA-C, HLA-DQ
Answer: A
Rationale: High-resolution matching at HLA-A, -B, and -DR (6/6) is the minimum standard. HLA-C and -DQ are also important, with 8/8 (A, B, C,
DR) being the current standard for matched unrelated donors. Mismatches at these key class I and II loci significantly increase GVHD risk.
3. Which conditioning regimen intensity is best described as resulting in irreversible pancytopenia requiring stem cell rescue, while reducing
regimen-related toxicity compared to myeloablative conditioning?
A) Myeloablative Conditioning (MAC)
B) Reduced-Intensity Conditioning (RIC)
C) Non-Myeloablative Conditioning (NMA)
, D) Lymphodepleting Conditioning
Answer: B
Rationale: RIC regimens (e.g., Flu/Mel140, Flu/Bu2) cause cytopenias of duration such that stem cell rescue is necessary, but at lower doses than
MAC. NMA regimens (e.g., Flu/TBI 2 Gy) are minimally toxic and can theoretically allow autologous recovery. MAC causes irreversible
pancytopenia.
4. A 55-year-old patient with myelofibrosis and a high HCT-CI score is being evaluated for transplant. Which conditioning intensity is preferred
to balance disease control with lower treatment-related mortality?
A) Cytoxan/TBI 1200 cGy
B) Fludarabine/Busulfan 3.2 mg/kg x 4 days
C) Fludarabine/Melphalan 140 mg/m²
D) Busulfan/Cyclophosphamide (BuCy)
Answer: C
(BMTCN)EXAM LATEST WITH ACTUAL QUESTIONS
AND CORRECT VERIFIED ANSWERS/ALREADY
GRADED A+ 100% GUARANTEED TO PASS
CONCEPTS(ALL WHAT YOU NEED) LATEST EDITION
,I. Foundations of Transplant (Questions 1-20)
1. A patient with acute myeloid leukemia (AML) with a monosomal karyotype is being evaluated for allogeneic transplant. The patient has no
matched sibling donor. Which alternative donor source is associated with the most rapid neutrophil engraftment?
A) 10/10 Matched Unrelated Donor (MUD) marrow
B) 5/10 Haploidentical peripheral blood stem cells
C) 6/6 Cord blood unit
D) 9/10 Mismatched Unrelated Donor (MMUD) marrow
Answer: B
Rationale: Haploidentical transplants using peripheral blood stem cells (PBSCs) typically result in neutrophil engraftment within 14-21 days,
comparable to matched related donors. Cord blood engraftment is significantly slower due to lower cell dose. Marrow grafts (MUD/MMUD)
engraft slower than PBSCs.
,2. A patient is undergoing HLA typing for an allogeneic transplant. Which HLA loci are considered most critical for matching to minimize the risk
of severe acute graft-versus-host disease (aGVHD)?
A) HLA-A, HLA-B, HLA-DR
B) HLA-C, HLA-DQ, HLA-DP
C) HLA-A, HLA-DR, HLA-DP
D) HLA-B, HLA-C, HLA-DQ
Answer: A
Rationale: High-resolution matching at HLA-A, -B, and -DR (6/6) is the minimum standard. HLA-C and -DQ are also important, with 8/8 (A, B, C,
DR) being the current standard for matched unrelated donors. Mismatches at these key class I and II loci significantly increase GVHD risk.
3. Which conditioning regimen intensity is best described as resulting in irreversible pancytopenia requiring stem cell rescue, while reducing
regimen-related toxicity compared to myeloablative conditioning?
A) Myeloablative Conditioning (MAC)
B) Reduced-Intensity Conditioning (RIC)
C) Non-Myeloablative Conditioning (NMA)
, D) Lymphodepleting Conditioning
Answer: B
Rationale: RIC regimens (e.g., Flu/Mel140, Flu/Bu2) cause cytopenias of duration such that stem cell rescue is necessary, but at lower doses than
MAC. NMA regimens (e.g., Flu/TBI 2 Gy) are minimally toxic and can theoretically allow autologous recovery. MAC causes irreversible
pancytopenia.
4. A 55-year-old patient with myelofibrosis and a high HCT-CI score is being evaluated for transplant. Which conditioning intensity is preferred
to balance disease control with lower treatment-related mortality?
A) Cytoxan/TBI 1200 cGy
B) Fludarabine/Busulfan 3.2 mg/kg x 4 days
C) Fludarabine/Melphalan 140 mg/m²
D) Busulfan/Cyclophosphamide (BuCy)
Answer: C
