Advanced Oncology Certified Nurse
(AOCN)EXAM NEWEST COMPLETE QUESTIONS
AND CORRECT VERIFIED ANSWERS(DETAILED
ANSWERS)|ALREADY GRADED A+
,Domain: Prevention and Early Detection
1. A 45-year-old woman with a BRCA1 mutation asks about chemoprevention for breast cancer. Which
medication is most appropriate to discuss?
A. Raloxifene
B. Tamoxifen
C. Anastrozole
D. Oral contraceptives
Answer: B. Tamoxifen
Rationale: Tamoxifen is FDA-approved for breast cancer risk reduction in premenopausal women with high risk,
such as those with BRCA mutations. Raloxifene is only indicated for postmenopausal women. Anastrozole is not
used for premenopausal women due to ovarian estrogen production. Oral contraceptives may slightly increase
breast cancer risk.
2. The Oncology Nurse Practitioner (ONP) is counseling a patient with familial adenomatous polyposis (FAP). At
what age should screening colonoscopies typically begin?
A. 20-25 years
B. 10-12 years
,C. 40-45 years
D. 30-35 years
Answer: B. 10-12 years
Rationale: FAP carries a nearly 100% risk of colorectal cancer. Screening with flexible sigmoidoscopy or
colonoscopy is recommended to start at puberty, generally ages 10-12, due to the early onset of polyps.
3. A 30-year-old woman undergoes genetic testing and is found to have Lynch syndrome. Which of the following
cancers is she at highest lifetime risk for?
A. Ovarian
B. Cervical
C. Endometrial
D. Breast
Answer: C. Endometrial
Rationale: Women with Lynch syndrome have a 40-60% lifetime risk of endometrial cancer, which can exceed
their risk of colorectal cancer. They also have increased risk for ovarian, gastric, and other cancers, but
endometrial is the most common extra-colonic malignancy.
, 4. Which vaccine is most effective for primary prevention of hepatocellular carcinoma?
A. HPV vaccine
B. Hepatitis B vaccine
C. BCG vaccine
D. Varicella vaccine
Answer: B. Hepatitis B vaccine
Rationale: Chronic Hepatitis B infection is a leading cause of hepatocellular carcinoma globally. Universal
vaccination against HBV represents a primary cancer prevention strategy.
5. A 35-year-old woman with a history of cervical dysplasia asks about the HPV vaccine. What is the current
guideline for catch-up vaccination?
A. Not recommended after age 26
B. Shared clinical decision-making for ages 27-45
C. Recommended for all adults up to age 59
D. Only recommended if new sexual partner identified
Answer: B. Shared clinical decision-making for ages 27-45
(AOCN)EXAM NEWEST COMPLETE QUESTIONS
AND CORRECT VERIFIED ANSWERS(DETAILED
ANSWERS)|ALREADY GRADED A+
,Domain: Prevention and Early Detection
1. A 45-year-old woman with a BRCA1 mutation asks about chemoprevention for breast cancer. Which
medication is most appropriate to discuss?
A. Raloxifene
B. Tamoxifen
C. Anastrozole
D. Oral contraceptives
Answer: B. Tamoxifen
Rationale: Tamoxifen is FDA-approved for breast cancer risk reduction in premenopausal women with high risk,
such as those with BRCA mutations. Raloxifene is only indicated for postmenopausal women. Anastrozole is not
used for premenopausal women due to ovarian estrogen production. Oral contraceptives may slightly increase
breast cancer risk.
2. The Oncology Nurse Practitioner (ONP) is counseling a patient with familial adenomatous polyposis (FAP). At
what age should screening colonoscopies typically begin?
A. 20-25 years
B. 10-12 years
,C. 40-45 years
D. 30-35 years
Answer: B. 10-12 years
Rationale: FAP carries a nearly 100% risk of colorectal cancer. Screening with flexible sigmoidoscopy or
colonoscopy is recommended to start at puberty, generally ages 10-12, due to the early onset of polyps.
3. A 30-year-old woman undergoes genetic testing and is found to have Lynch syndrome. Which of the following
cancers is she at highest lifetime risk for?
A. Ovarian
B. Cervical
C. Endometrial
D. Breast
Answer: C. Endometrial
Rationale: Women with Lynch syndrome have a 40-60% lifetime risk of endometrial cancer, which can exceed
their risk of colorectal cancer. They also have increased risk for ovarian, gastric, and other cancers, but
endometrial is the most common extra-colonic malignancy.
, 4. Which vaccine is most effective for primary prevention of hepatocellular carcinoma?
A. HPV vaccine
B. Hepatitis B vaccine
C. BCG vaccine
D. Varicella vaccine
Answer: B. Hepatitis B vaccine
Rationale: Chronic Hepatitis B infection is a leading cause of hepatocellular carcinoma globally. Universal
vaccination against HBV represents a primary cancer prevention strategy.
5. A 35-year-old woman with a history of cervical dysplasia asks about the HPV vaccine. What is the current
guideline for catch-up vaccination?
A. Not recommended after age 26
B. Shared clinical decision-making for ages 27-45
C. Recommended for all adults up to age 59
D. Only recommended if new sexual partner identified
Answer: B. Shared clinical decision-making for ages 27-45
