USMLE STEP 1 LATEST EXAM REVIEW 2026–2027 Complete Study Guide Featuring Practice Questions, Board Preparation & High Yield Concepts

USMLE STEP 1 LATEST EXAM REVIEW
2026–2027 Complete Study Guide Featuring
Practice Questions, Board Preparation & High-
Yield Concepts


1. A 45-year-old male presents with numbness and tingling in the lateral aspect
of his right hand. Which nerve is most likely affected?
A. Ulnar nerve
B. Radial nerve
C. Median nerve
D. Musculocutaneous nerve
E. Median nerve
2. A patient has difficulty adducting and rotating their arm medially. Which
muscle is most likely affected?
A. Deltoid
B. Supraspinatus
C. Teres major
D. Latissimus dorsi
E. Latissimus dorsi
3. Which structure passes through the foramen magnum?
A. Vagus nerve
B. Spinal cord
C. Internal carotid artery
D. Vertebral artery
E. Spinal cord
4. A 60-year-old male with prostate cancer is at risk for metastasis to which
bone site?
A. Skull
B. Ribs
C. Vertebrae

, D. Femur
E. Vertebrae
5. Which cranial nerve is responsible for the sensation of taste in the anterior
two-thirds of the tongue?
A. Glossopharyngeal nerve (CN IX)
B. Vagus nerve (CN X)
C. Trigeminal nerve (CN V)
D. Facial nerve (CN VII)
E. Facial nerve (CN VII)
6. The appendix is located in which abdominal quadrant?
A. Left upper quadrant
B. Right upper quadrant
C. Left lower quadrant
D. Right lower quadrant
E. Right lower quadrant
7. A patient has difficulty extending their wrist and fingers. Which nerve is
most likely damaged?
A. Ulnar nerve
B. Median nerve
C. Radial nerve
D. Axillary nerve
E. Radial nerve
8. Which structure is located in the femoral triangle?
A. Sciatic nerve
B. Femoral artery
C. Pudendal nerve
D. Obturator nerve
E. Femoral artery
9. The ligamentum arteriosum is a remnant of which fetal structure?
A. Umbilical vein
B. Ductus venosus
C. Ductus arteriosus
D. Foramen ovale
E. Ductus arteriosus

,10.Which muscle is the primary muscle of respiration?
A. External intercostals
B. Internal intercostals
C. Diaphragm
D. Scalene muscles
E. Diaphragm
11.A 30-year-old female presents with carpal tunnel syndrome. Which nerve is
compressed?
A. Ulnar nerve
B. Radial nerve
C. Median nerve
D. Musculocutaneous nerve
E. Median nerve
12.The pituitary gland is located in which bony structure?
A. Sphenoid bone
B. Ethmoid bone
C. Temporal bone
D. Occipital bone
E. Sphenoid bone
13.Which artery supplies the majority of the brain?
A. Internal carotid artery
B. External carotid artery
C. Vertebral artery
D. Basilar artery
E. Internal carotid artery
14.A patient has difficulty swallowing and speaking. Which cranial nerve is
most likely affected?
A. Trigeminal nerve (CN V)
B. Facial nerve (CN VII)
C. Glossopharyngeal nerve (CN IX)
D. Hypoglossal nerve (CN XII)
E. Glossopharyngeal nerve (CN IX)
15.The renal artery enters the kidney at which location?
A. Cortex
B. Medulla

, C. Hilum
D. Pelvis
E. Hilum
16.Which structure separates the right and left ventricles?
A. Interatrial septum
B. Interventricular septum
C. Atrioventricular septum
D. Chordae tendineae
E. Interventricular septum
17.A patient has weakness in dorsiflexion and eversion of the foot. Which nerve
is damaged?
A. Tibial nerve
B. Common peroneal nerve
C. Deep peroneal nerve
D. Superficial peroneal nerve
E. Common peroneal nerve
18.The gallbladder is located in which abdominal quadrant?
A. Left upper quadrant
B. Right upper quadrant
C. Left lower quadrant
D. Right lower quadrant
E. Right upper quadrant
19.Which muscle is responsible for abduction of the arm at the shoulder?
A. Deltoid
B. Latissimus dorsi
C. Pectoralis major
D. Teres major
E. Deltoid
20.The cauda equina is composed of which structures?
A. Spinal nerve roots
B. Spinal cord
C. Meninges
D. Vertebral bodies
E. Spinal nerve roots