Cyclophosphamide, Ifosfamide: MOA & AEs
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MOA: Alkylating agent; cross-link DNA at guanine N-7; require
bioactivation by liver
AE: myelosuppression, hemorrhagic cystitis (prevent w/ Mesna or N-
acetylcysteine)
Child taking medication for seizures has GI effects, fatigue, headache, urticaria,
Stevens-Johnson syndrome -- what drug?
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, Ethosuximide
Pt treated for depression develops GI dystress, SIADH, sexual dysfunction (decreased
libido). Cause? Treatment?
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SSRIs = Fluoxetine, Paroxetine, Sertraline, Citalopram ("Flashbacks Paralyze
Senior Citizens")
Tx: switch to Bupropion (no sexual side effects)
MOA of Echinocandins (-fungin)
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inhibit fungal cell wall synthesis by inhibiting synthesis of beta-glucan
1st line Tx for absence seizures (MOA?)
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Ethosuximide - blocks thalamic T-type Ca channels; can also use Valproate
or Lamotrigine
,Pt is treated for pneumonia/lung abscess/mouth infection and soon develops fever
and severe, foul-smelling, watery diarrhea.
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Clindamycin
Pt develops pseudomembranous colitis due to C. diff overgrowth
Smoking cessation Tx and MOA
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Bupropion (increases NE & DA)
Varenicline (nicotinic ACh receptor partial agonist)
Heparin MOA
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Lowers activity of thrombin and factor Xa by binding to anti-thrombin (AT)
III; short half-life; immediate anticoagulation
Dactinomycin: MOA & AEs
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, MOA: Antitumor antibiotic; intercalates in DNA
AE: myelosuppression
Tx for generalized anxiety disorder
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SSRIs, SNRIs, Buspirone (stimulates 5-HT 1A)
Tx for severe headaches? Contraindications?
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Sumatriptan (5-HT 1B/1D agonist; inhibit trigeminal activation;
vasoconstriction)
Contraindicated in pts w/ CAD or Prinzmetal angina due to coronary
vasopspasms (adverse effect)
Pt given anesthetics develops severe fever and muscle contractions
Diagnosis? Cause?
Treatment?
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Malignant Hyperthermia (autosomal dominant, variable penetrance,
ryanodine receptor mutation causes increased Ca release from SR)
Caused by inhaled anesthetics (-fluranes, N2O) or succinylcholine
Give this one a try later!
MOA: Alkylating agent; cross-link DNA at guanine N-7; require
bioactivation by liver
AE: myelosuppression, hemorrhagic cystitis (prevent w/ Mesna or N-
acetylcysteine)
Child taking medication for seizures has GI effects, fatigue, headache, urticaria,
Stevens-Johnson syndrome -- what drug?
Give this one a try later!
, Ethosuximide
Pt treated for depression develops GI dystress, SIADH, sexual dysfunction (decreased
libido). Cause? Treatment?
Give this one a try later!
SSRIs = Fluoxetine, Paroxetine, Sertraline, Citalopram ("Flashbacks Paralyze
Senior Citizens")
Tx: switch to Bupropion (no sexual side effects)
MOA of Echinocandins (-fungin)
Give this one a try later!
inhibit fungal cell wall synthesis by inhibiting synthesis of beta-glucan
1st line Tx for absence seizures (MOA?)
Give this one a try later!
Ethosuximide - blocks thalamic T-type Ca channels; can also use Valproate
or Lamotrigine
,Pt is treated for pneumonia/lung abscess/mouth infection and soon develops fever
and severe, foul-smelling, watery diarrhea.
Give this one a try later!
Clindamycin
Pt develops pseudomembranous colitis due to C. diff overgrowth
Smoking cessation Tx and MOA
Give this one a try later!
Bupropion (increases NE & DA)
Varenicline (nicotinic ACh receptor partial agonist)
Heparin MOA
Give this one a try later!
Lowers activity of thrombin and factor Xa by binding to anti-thrombin (AT)
III; short half-life; immediate anticoagulation
Dactinomycin: MOA & AEs
Give this one a try later!
, MOA: Antitumor antibiotic; intercalates in DNA
AE: myelosuppression
Tx for generalized anxiety disorder
Give this one a try later!
SSRIs, SNRIs, Buspirone (stimulates 5-HT 1A)
Tx for severe headaches? Contraindications?
Give this one a try later!
Sumatriptan (5-HT 1B/1D agonist; inhibit trigeminal activation;
vasoconstriction)
Contraindicated in pts w/ CAD or Prinzmetal angina due to coronary
vasopspasms (adverse effect)
Pt given anesthetics develops severe fever and muscle contractions
Diagnosis? Cause?
Treatment?
Give this one a try later!
Malignant Hyperthermia (autosomal dominant, variable penetrance,
ryanodine receptor mutation causes increased Ca release from SR)
Caused by inhaled anesthetics (-fluranes, N2O) or succinylcholine
