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NURS 5461 Fluid & Electrolyte Replacement | 180+ Exam Questions & Verified Answers | IV Fluid Therapy, Crystalloids, Colloids, Electrolytes, Dehydration & Fluid Resuscitation | MSN/FNP

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Master NURS 5461 Fluid & Electrolyte Replacement with this comprehensive study guide featuring 180+ exam-style questions and verified answers covering the essential principles of fluid balance, intravenous fluid therapy, electrolyte management, and evidence-based fluid resuscitation. This resource provides in-depth review of total body water distribution, extracellular and intracellular fluid compartments, effective arterial blood volume (EABV), dehydration assessment, fluid deficit recognition, maintenance and replacement fluid calculations, crystalloid and colloid solutions, isotonic, hypotonic, and hypertonic intravenous fluids, sodium disorders, potassium replacement, burn resuscitation, fluid therapy in older adults, albumin therapy, dextran, hetastarch, lactated Ringer's solution, normal saline, D5W, D5NS, D5½NS, hypertonic saline, acid-base considerations, intravenous maintenance therapy, and clinical fluid selection. The structured question-and-answer format strengthens clinical reasoning, dosage calculations, fluid management, and evidence-based decision-making required for graduate nursing examinations and advanced clinical practice. This study guide is specifically designed for students enrolled in NURS 5461 Advanced Pathophysiology and graduate nursing programs preparing for examinations, clinical assessments, and advanced practice certification. The content integrates physiology, pathophysiology, pharmacology, and intravenous fluid management with practical clinical scenarios encountered in acute care, emergency medicine, perioperative care, critical care, and primary care settings. Learners will strengthen their understanding of maintenance fluid requirements, fluid replacement strategies, electrolyte abnormalities, burn management, dehydration, hypovolemia, shock resuscitation, renal considerations, fluid selection, and intravenous therapy principles used in evidence-based patient care. This resource is ideal for classroom revision, independent study, clinical rotations, NCLEX preparation, nurse practitioner board examinations, and advanced nursing practice. The material is consistent with evidence-based recommendations presented in McCance & Huether's Pathophysiology: The Biologic Basis for Disease in Adults and Children, Marino's The ICU Book, Current Medical Diagnosis & Treatment (CMDT), the Surviving Sepsis Campaign Guidelines, the American Burn Association (ABA) fluid resuscitation recommendations, the Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guidelines, the American Association of Critical-Care Nurses (AACN) standards, and the Infusion Nurses Society (INS) Infusion Therapy Standards of Practice. These internationally recognized references provide the scientific and clinical foundation for intravenous fluid therapy, electrolyte management, hemodynamic stabilization, and evidence-based patient care across acute and critical care settings. Relevant Students: NURS 5461 students, Master of Science in Nursing (MSN) students, Family Nurse Practitioner (FNP) students, Adult-Gerontology Nurse Practitioner (AGNP) students, Doctor of Nursing Practice (DNP) students, Advanced Practice Registered Nurse (APRN) students, Nurse Practitioner students, Registered Nursing (RN) students, Bachelor of Science in Nursing (BSN) students, Clinical Nurse Specialist (CNS) students, Critical Care Nursing students, Emergency Nursing students, Physician Assistant (PA) students, Medical students, Advanced Pathophysiology students, Advanced Pharmacology students, and healthcare professionals preparing for graduate nursing examinations. Keywords: NURS 5461, Fluid Replacement, Fluid Therapy, Fluid and Electrolyte Balance, Intravenous Fluids, IV Fluid Therapy, Crystalloids, Colloids, Normal Saline, Lactated Ringers, D5W, D5NS, D5 Half Normal Saline, Hypertonic Saline, Hypotonic Fluids, Isotonic Fluids, Albumin, Dextran, Hetastarch, Fluid Resuscitation, Maintenance Fluids, Replacement Fluids, Effective Arterial Blood Volume, EABV, Total Body Water, Extracellular Fluid, Intracellular Fluid, Electrolyte Management, Sodium Disorders, Potassium Replacement, Dehydration, Hypovolemia, Burn Resuscitation, Shock Management, Intravenous Therapy, Critical Care Nursing, Advanced Pathophysiology, Clinical Calculations, Practice Questions, Verified Answers, Nursing Exam Preparation, Nurse Practitioner Review, Advanced Nursing Practice.

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NURS 5461 Fluid Replacement
Questions and answers 2026

a. Fluid Replacement - ANSWER ✔✔I/O equal ~1600mL/day


1. Total Body Water - ANSWER ✔✔a. Adult males


i. < 65 y/o = 60%

ii. > 65 y/o = 50%

b. Adult females

i. < 65 y/o = 50%

> 65 y/o = 45%


Extracellular fluid volume - ANSWER ✔✔1. 1/3 TWB


2. Controlled by Na retention and excretion

3. Water passively follows sodium

, 4. Body ignores ECF as a whole

a. Samples a portion of it EABV


a. Effective Arterial Blood Volume - ANSWER ✔✔b. Effective Arterial

Blood Volume

i. Volume in the arteries

ii. ~ 700ml

iii. Function of cardiac output and systemic vascular resistance

*Baro-receptors sense changes in the EABV

-Decreased EABV- increase release of catecholamines and increases

CO and SVR, activates RAAS, increased antidiuretic hormone secretion

-Increase EABV- suppresses RAAS, increase release of atrial natriuretic

peptide


i. Manifestations of Dehydration/Volume Loss - ANSWER ✔✔1.

Thirst, Delayed capillary refill

2. Dry mucous membranes, cool clammy skin

3. Tachypnea

4. Tachycardia with pulse > 100

5. Postural hypotension (SBP decrease > 20mmHg with standing)

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