NR 565
ADVANCED PHARMACOLOGY
MIDTERM -EXAM
LATEST VERSION WITH CORRECT
ANSWERS GRADED A+
,During what trimester is a pregnant woman most at risk for adverse drug
reactions with potential long term consequences? - CORRECT ANSWER - 1st
trimester (fetus most at risk d/t rapid growth)
What is BEERS criteria? - CORRECT ANSWER - Recommendations of medications
inappropriate for elderly (65 and older), prescriber ultimately decides
What is the CYP450 (cytochrome P450) - CORRECT ANSWER - liver enzyme
system where medications are metabolized, can either be inducers or inhibitors
and create drug-drug interactions
CYP450 inducers - CORRECT ANSWER - Speed up metabolism of drugs (drug is
cleared faster), drug has lesser effect (decrease blood levels of drug), elevate
CYP450 enzymes
CYP450 inducers pneumonic - CORRECT ANSWER - "Bullshit Crap GPS INDUCES
rage"
,CYP450 inducer drug names - CORRECT ANSWER - Barbituates, St John wort,
Carbamazepine, rifampin, alcohol, phenytoin, griseofulvin, phenobarbital,
sulfonylureas
CYP450 inhibitors - CORRECT ANSWER - inhibit metabolism, increase blood
levels of medications
CYP450 pneumonic - CORRECT ANSWER - "VISA credit card debt INHIBITS
spending on designers like CK to look GQ"
CYP450 inhibitors drug names - CORRECT ANSWER - Valproate, isoniazid,
sulfonamides, amiodarone, chloramphenicol, ketoconazole, grapefruit juice,
quinidine
Physiological changes during pregnancy that impact pharmacodynamics and
pharmacokinetic properties of drugs? - CORRECT ANSWER - increase glomerular
filtration rate leads to increase durg excretion
increase hepatic metabolism
decrease tone and motility of bowel
increase drug absorption
, Examples of medications that can be teratogenic - CORRECT ANSWER -
Antiepileptic drugs, antimicrobials such as tetracyclines and fluoroquinolones,
vitamin A in large doses, some anticoagulants, and hormonal medications such as
diethylstilbestrol (DES).
How is absorption of intramuscular medications different in neonates? - CORRECT
ANSWER - slow and erratic due to low blood flow in muscles first few days of life
Why is absorption of medication in the stomach increased in infancy? - CORRECT
ANSWER - delayed gastric emptying
Some medications that should be avoided in the pediatric patient? - CORRECT
ANSWER - glucocorticoids, discoloration of developing teeth with tetracyclines,
and kernicterus with sulfonamides, levofloxacin (antibiotics)
aspirin (Severe intoxication from acute overdose)
what should be included in medication administration patient education? -
CORRECT ANSWER - dosage size and timing
route and technique of administration
duration of treatment
drug storage
ADVANCED PHARMACOLOGY
MIDTERM -EXAM
LATEST VERSION WITH CORRECT
ANSWERS GRADED A+
,During what trimester is a pregnant woman most at risk for adverse drug
reactions with potential long term consequences? - CORRECT ANSWER - 1st
trimester (fetus most at risk d/t rapid growth)
What is BEERS criteria? - CORRECT ANSWER - Recommendations of medications
inappropriate for elderly (65 and older), prescriber ultimately decides
What is the CYP450 (cytochrome P450) - CORRECT ANSWER - liver enzyme
system where medications are metabolized, can either be inducers or inhibitors
and create drug-drug interactions
CYP450 inducers - CORRECT ANSWER - Speed up metabolism of drugs (drug is
cleared faster), drug has lesser effect (decrease blood levels of drug), elevate
CYP450 enzymes
CYP450 inducers pneumonic - CORRECT ANSWER - "Bullshit Crap GPS INDUCES
rage"
,CYP450 inducer drug names - CORRECT ANSWER - Barbituates, St John wort,
Carbamazepine, rifampin, alcohol, phenytoin, griseofulvin, phenobarbital,
sulfonylureas
CYP450 inhibitors - CORRECT ANSWER - inhibit metabolism, increase blood
levels of medications
CYP450 pneumonic - CORRECT ANSWER - "VISA credit card debt INHIBITS
spending on designers like CK to look GQ"
CYP450 inhibitors drug names - CORRECT ANSWER - Valproate, isoniazid,
sulfonamides, amiodarone, chloramphenicol, ketoconazole, grapefruit juice,
quinidine
Physiological changes during pregnancy that impact pharmacodynamics and
pharmacokinetic properties of drugs? - CORRECT ANSWER - increase glomerular
filtration rate leads to increase durg excretion
increase hepatic metabolism
decrease tone and motility of bowel
increase drug absorption
, Examples of medications that can be teratogenic - CORRECT ANSWER -
Antiepileptic drugs, antimicrobials such as tetracyclines and fluoroquinolones,
vitamin A in large doses, some anticoagulants, and hormonal medications such as
diethylstilbestrol (DES).
How is absorption of intramuscular medications different in neonates? - CORRECT
ANSWER - slow and erratic due to low blood flow in muscles first few days of life
Why is absorption of medication in the stomach increased in infancy? - CORRECT
ANSWER - delayed gastric emptying
Some medications that should be avoided in the pediatric patient? - CORRECT
ANSWER - glucocorticoids, discoloration of developing teeth with tetracyclines,
and kernicterus with sulfonamides, levofloxacin (antibiotics)
aspirin (Severe intoxication from acute overdose)
what should be included in medication administration patient education? -
CORRECT ANSWER - dosage size and timing
route and technique of administration
duration of treatment
drug storage
